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ONTOLOGY REPORT - ANNOTATIONS

Term:mast cell degranulation
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Accession:GO:0043303 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
Synonyms:exact_synonym: mast cell granule exocytosis

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mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor acts_upstream_of ISO (PMID:11454903) MGI PMID:11454903 NCBI chrNW_004624877:4,421,307...4,447,574
Ensembl chrNW_004624877:4,422,022...4,447,460 		JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of ISO (PMID:12817016) MGI PMID:12817016 NCBI chrNW_004624772:7,189,381...7,232,919
Ensembl chrNW_004624772:7,229,093...7,232,837 		JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:18243321 RGD:11576314 NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575 		JBrowse link
G Cd300a CD300a molecule acts_upstream_of ISO (PMID:12874256) MGI PMID:12874256 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Chga chromogranin A involved_in ISO (PMID:21214543) UniProt PMID:21214543 NCBI chrNW_004624734:9,405,121...9,416,774
Ensembl chrNW_004624734:9,404,916...9,416,902 		JBrowse link
G Clnk cytokine dependent hematopoietic cell linker involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624755:20,667,325...20,817,497 JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia involved_in
acts_upstream_of		 ISO (PMID:8551243)
(PMID:9000133)		 UniProt
MGI		 PMID:8551243 PMID:9000133 NCBI chrNW_004624794:2,003,031...2,008,930
Ensembl chrNW_004624794:2,002,928...2,008,940 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of ISO (PMID:14764707) MGI PMID:14764707 NCBI chrNW_004624794:168,564...172,433
Ensembl chrNW_004624794:168,564...172,034 		JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624841:2,845,796...2,852,575
Ensembl chrNW_004624841:2,846,117...2,852,539 		JBrowse link
G Grp gastrin releasing peptide involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624792:4,623,082...4,633,545
Ensembl chrNW_004624792:4,623,097...4,633,570 		JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase involved_in ISO (PMID:20100931) UniProt PMID:20100931 NCBI chrNW_004624761:14,733,912...14,831,428 JBrowse link
G Milr1 mast cell immunoglobulin like receptor 1 involved_in ISO (MGI:4461821|PMID:20526344) UniProt PMID:20526344 MGI:4461821 NCBI chrNW_004624870:85,695...142,842 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 involved_in ISO (MGI:5586645|PMID:24586680) UniProt PMID:24586680 MGI:5586645 NCBI chrNW_004624825:1,098,915...1,141,373
Ensembl chrNW_004624825:1,097,432...1,141,446 		JBrowse link
G Pla2g3 phospholipase A2 group III acts_upstream_of_or_within ISO (PMID:23624557) MGI PMID:23624557 NCBI chrNW_004624747:7,602,848...7,607,872
Ensembl chrNW_004624747:7,603,277...7,607,753 		JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:920,292...923,174
Ensembl chrNW_004624760:920,877...923,283 		JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO (PMID:32238914) MGI PMID:32238914 NCBI chrNW_004624754:21,072,113...21,092,517 JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of ISO (PMID:15235600) MGI PMID:15235600 NCBI chrNW_004624740:8,624,231...8,688,747
Ensembl chrNW_004624740:8,624,205...8,690,800 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17190838) Ensembl
MGI		 PMID:17190838 GO_REF:0000107 NCBI chrNW_004624804:5,691,011...5,763,314
Ensembl chrNW_004624804:5,690,400...5,763,288 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO (PMID:31534133) MGI PMID:31534133 NCBI chrNW_004624731:2,065,228...2,203,215 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:9000133) Ensembl
MGI		 PMID:9000133 GO_REF:0000107 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391 		JBrowse link
histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO (PMID:12817016) MGI PMID:12817016 NCBI chrNW_004624772:7,189,381...7,232,919
Ensembl chrNW_004624772:7,229,093...7,232,837 		JBrowse link
G Btk Bruton tyrosine kinase ISO RGD PMID:12220673 RGD:1600535 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:16177098 RGD:1578516 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO (PMID:32238914) MGI PMID:32238914 NCBI chrNW_004624754:21,072,113...21,092,517 JBrowse link
G Slc18a2 solute carrier family 18 member A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:29,356,590...29,388,099
Ensembl chrNW_004624737:29,358,696...29,387,808 		JBrowse link
G Snap23 synaptosome associated protein 23 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624804:9,609,777...9,643,670
Ensembl chrNW_004624804:9,610,308...9,641,933 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO RGD PMID:12499633 RGD:1625716 NCBI chrNW_004624763:7,722,275...7,723,482 JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a CD300a molecule involved_in
acts_upstream_of_or_within		 ISO (PMID:16339535)
(PMID:12874256)		 UniProt
MGI		 PMID:12874256 PMID:16339535 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Cd84 CD84 molecule involved_in ISO (PMID:22068234) UniProt PMID:22068234 NCBI chrNW_004624794:709,169...742,591
Ensembl chrNW_004624794:709,235...740,846 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO (PMID:18421012) MGI PMID:18421012 NCBI chrNW_004624746:2,599,211...2,603,031
Ensembl chrNW_004624746:2,599,106...2,603,336 		JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:17234154 RGD:1601626 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15944273) Ensembl
MGI		 PMID:15944273 GO_REF:0000107 NCBI chrNW_004624940:825,368...842,268
Ensembl chrNW_004624940:819,854...842,284 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:24465902) UniProt PMID:24465902 NCBI chrNW_004624786:478,048...491,086 JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (PMID:15235600) MGI PMID:15235600 NCBI chrNW_004624740:8,624,231...8,688,747
Ensembl chrNW_004624740:8,624,205...8,690,800 		JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004624818:1,147,654...1,149,722
Ensembl chrNW_004624818:1,147,974...1,148,927 		JBrowse link
G Pla2g3 phospholipase A2 group III involved_in ISO (MGI:5492190|PMID:23624557)
(PMID:23624557)		 UniProt PMID:23624557 MGI:5492190 NCBI chrNW_004624747:7,602,848...7,607,872
Ensembl chrNW_004624747:7,603,277...7,607,753 		JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624731:1,522,467...1,585,793
Ensembl chrNW_004624731:1,522,098...1,586,066 		JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624980:40,937...94,547
Ensembl chrNW_004624980:40,843...94,528 		JBrowse link
G Vamp8 vesicle associated membrane protein 8 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624749:17,558,429...17,562,765
Ensembl chrNW_004624749:17,558,429...17,562,723 		JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor acts_upstream_of_or_within ISO (PMID:11454903) MGI PMID:11454903 NCBI chrNW_004624877:4,421,307...4,447,574
Ensembl chrNW_004624877:4,422,022...4,447,460 		JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO (PMID:12817016) MGI PMID:12817016 NCBI chrNW_004624772:7,189,381...7,232,919
Ensembl chrNW_004624772:7,229,093...7,232,837 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:18209484 RGD:5130941 NCBI chrNW_004624849:2,484,144...2,528,130
Ensembl chrNW_004624849:2,484,109...2,528,223 		JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) MGI PMID:9000133 NCBI chrNW_004624794:2,003,031...2,008,930
Ensembl chrNW_004624794:2,002,928...2,008,940 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:14764707) MGI PMID:14764707 NCBI chrNW_004624794:168,564...172,433
Ensembl chrNW_004624794:168,564...172,034 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5294498|PMID:21746961) UniProt PMID:21746961 MGI:5294498 NCBI chrNW_004624764:11,482,719...11,513,215
Ensembl chrNW_004624764:11,489,685...11,513,270 		JBrowse link
G Gab2 GRB2 associated binding protein 2 involved_in ISO (MGI:2137187|PMID:11449275) UniProt PMID:11449275 MGI:2137187 NCBI chrNW_004624863:1,216,664...1,410,934
Ensembl chrNW_004624863:1,219,866...1,281,847 		JBrowse link
G Gata1 GATA binding protein 1 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004624893:595,948...602,980
Ensembl chrNW_004624893:595,967...602,979 		JBrowse link
G Gata2 GATA binding protein 2 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004624961:147,685...155,614
Ensembl chrNW_004624961:143,358...154,003 		JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Ms4a2 membrane spanning 4-domains A2 ISO RGD PMID:16177098 RGD:1578516 NCBI chrNW_004624864:804,950...813,419
Ensembl chrNW_004624864:807,253...813,381 		JBrowse link
G Nppc natriuretic peptide C involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004624843:4,869,278...4,873,444
Ensembl chrNW_004624843:4,869,614...4,873,448 		JBrowse link
G Pld2 phospholipase D2 ISO RGD PMID:16861349 RGD:2299903 NCBI chrNW_004624786:8,690,968...8,702,213
Ensembl chrNW_004624786:8,690,461...8,702,771 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) UniProt PMID:17346996 MGI:3703830 NCBI chrNW_004624832:5,246,328...5,254,247
Ensembl chrNW_004624832:5,246,895...5,253,207 		JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004624760:7,843,741...7,914,444
Ensembl chrNW_004624760:7,842,640...7,914,484 		JBrowse link
G Stxbp2 syntaxin binding protein 2 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004624828:718,728...725,063
Ensembl chrNW_004624828:718,485...725,483 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9000133) MGI
Ensembl
TreeGrafter
RGD		 PMID:9000133 PMID:16861349 GO_REF:0000107 GO_REF:0000118 RGD:2299903 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391 		JBrowse link
regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx6 sorting nexin 6 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624838:2,105,558...2,146,064
Ensembl chrNW_004624838:2,105,619...2,145,268 		JBrowse link
G Vamp2 vesicle associated membrane protein 2 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624786:10,723,791...10,727,654
Ensembl chrNW_004624786:10,724,964...10,727,649 		JBrowse link
G Vamp3 vesicle associated membrane protein 3 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004624818:4,010,130...4,019,695
Ensembl chrNW_004624818:4,009,991...4,019,728 		JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fer FER tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624743:26,663,440...27,097,771
Ensembl chrNW_004624743:26,694,465...27,091,250 		JBrowse link
G Ferry3 FERRY endosomal RAB5 effector complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624860:1,592,889...1,627,298
Ensembl chrNW_004624860:1,593,318...1,625,422 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624768:17,360,602...17,372,563
Ensembl chrNW_004624768:17,359,196...17,372,712 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 involved_in ISO (MGI:5298334|PMID:21063107) UniProt PMID:21063107 MGI:5298334 NCBI chrNW_004624824:279,893...383,220
Ensembl chrNW_004624824:293,374...383,156 		JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (MGI:3655336|PMID:10843388) CACAO PMID:10843388 MGI:3655336 NCBI chrNW_004624752:10,589,017...10,620,652
Ensembl chrNW_004624752:10,589,017...10,601,661 		JBrowse link
G Stxbp2 syntaxin binding protein 2 ISO RGD PMID:12482918 RGD:2312429 NCBI chrNW_004624828:718,728...725,063
Ensembl chrNW_004624828:718,485...725,483 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO (PMID:15548590) UniProt PMID:15548590 NCBI chrNW_004624801:5,720,998...5,736,122
Ensembl chrNW_004624801:5,721,391...5,736,294 		JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a CD300a molecule acts_upstream_of_or_within ISO (PMID:12874256) MGI PMID:12874256 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:29,356,590...29,388,099
Ensembl chrNW_004624737:29,358,696...29,387,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    localization 4970
      organelle localization 592
        establishment of organelle localization 449
          mast cell degranulation 57
            histamine secretion by mast cell + 15
            negative regulation of mast cell degranulation 7
            positive regulation of mast cell degranulation + 24
            regulation of mast cell degranulation + 38
            serotonin secretion by mast cell 2
Path 2
Term Annotations click to browse term
  biological_process 15093
    localization 4970
      establishment of localization 4307
        transport 4014
          export from cell 988
            secretion by cell 923
              exocytosis 360
                regulated exocytosis 251
                  leukocyte degranulation 80
                    mast cell degranulation 57
                      histamine secretion by mast cell + 15
                      negative regulation of mast cell degranulation 7
                      positive regulation of mast cell degranulation + 24
                      regulation of mast cell degranulation + 38
                      serotonin secretion by mast cell 2
paths to the root