Gata2 (GATA binding protein 2) - Rat Genome Database

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Gene: Gata2 (GATA binding protein 2) Heterocephalus glaber
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Symbol: Gata2
Name: GATA binding protein 2
RGD ID: 18933527
Description: ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN angiogenesis (ortholog); brown fat cell differentiation (ortholog); cell differentiation in hindbrain (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alkaptonuria (ortholog); anemia (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Endothelial transcription factor GATA-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624961143,358 - 154,003 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ development  (IEA)
brown fat cell differentiation  (ISO)
cell differentiation  (IEA)
cell differentiation in hindbrain  (ISO)
cell fate commitment  (IEA)
cell fate determination  (ISO)
central nervous system neuron development  (ISO)
cochlea development  (ISO)
commitment of neuronal cell to specific neuron type in forebrain  (ISO)
definitive hemopoiesis  (ISO)
embryonic placenta development  (ISO)
eosinophil fate commitment  (ISO)
fat cell differentiation  (ISO)
GABAergic neuron differentiation  (ISO)
glandular epithelial cell differentiation  (ISO)
glandular epithelial cell maturation  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hematopoietic stem cell homeostasis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inner ear morphogenesis  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hematopoietic progenitor cell differentiation  (ISO)
negative regulation of macrophage differentiation  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neural precursor cell proliferation  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural precursor cell proliferation  (ISO)
neuroblast proliferation  (ISO)
neuroendocrine cell differentiation  (ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuron maturation  (ISO)
neuron migration  (ISO)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of megakaryocyte differentiation  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of forebrain neuron differentiation  (ISO)
regulation of primitive erythrocyte differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to lipid  (ISO)
semicircular canal development  (ISO)
somatic stem cell population maintenance  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
urogenital system development  (ISO)
vascular wound healing  (ISO)
ventral spinal cord interneuron differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gata2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624961143,358 - 154,003 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GATA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383128,479,422 - 128,493,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3128,479,427 - 128,493,201 (-)EnsemblGRCh38hg38GRCh38
GRCh373128,198,265 - 128,212,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,680,960 - 129,694,718 (-)NCBINCBI36Build 36hg18NCBI36
Build 343129,680,969 - 129,694,726NCBI
Celera3126,626,234 - 126,639,997 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3125,582,307 - 125,596,070 (-)NCBIHuRef
CHM1_13128,161,207 - 128,175,078 (-)NCBICHM1_1
T2T-CHM13v2.03131,220,983 - 131,234,760 (-)NCBIT2T-CHM13v2.0
Gata2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,170,873 - 88,184,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl688,170,873 - 88,184,014 (+)EnsemblGRCm39 Ensembl
GRCm38688,193,891 - 88,207,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,148,658 - 88,157,026 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36688,164,309 - 88,172,670 (+)NCBIMGSCv36mm8
Celera690,136,051 - 90,144,243 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.2NCBI
Gata2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,211,501 - 122,225,058 (+)NCBIGRCr8
mRatBN7.24120,654,205 - 120,667,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,658,986 - 120,667,761 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4126,131,415 - 126,140,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,906,173 - 121,914,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,530,424 - 120,539,200 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04120,129,028 - 120,142,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,369,926 - 185,383,944 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,279,753 - 122,288,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14122,524,233 - 122,533,009 (+)NCBI
Celera4109,615,354 - 109,624,129 (+)NCBICelera
Cytogenetic Map4q34NCBI
Gata2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,327,113 - 15,336,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,326,551 - 15,334,774 (+)NCBIChiLan1.0ChiLan1.0
GATA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,405,346 - 126,413,849 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13126,410,062 - 126,418,571 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03125,526,537 - 125,535,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13132,890,508 - 132,899,035 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,890,508 - 132,899,035 (-)Ensemblpanpan1.1panPan2
GATA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,472,251 - 2,488,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,473,912 - 2,480,991 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,508,307 - 2,517,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0202,492,701 - 2,501,504 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl202,492,704 - 2,565,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1202,213,473 - 2,222,266 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0202,540,074 - 2,548,847 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0202,500,417 - 2,509,217 (-)NCBIUU_Cfam_GSD_1.0
Gata2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,364,390 - 20,372,921 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936798406,258 - 414,931 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936798406,258 - 414,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,984,067 - 71,997,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,606,930 - 79,613,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,549,112 - 52,562,911 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,555,738 - 52,562,909 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041113,794,573 - 113,808,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000001306   ⟹   ENSHGLP00000001264
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624961143,358 - 154,003 (+)Ensembl
RefSeq Acc Id: XM_004875141   ⟹   XP_004875198
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBI
RefSeq Acc Id: XM_021252440   ⟹   XP_021108099
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004875198 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108099 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001264
GenBank Protein JAN97165 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004875198   ⟸   XM_004875141
- Peptide Label: isoform X1
- UniProtKB: G5BII6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108099   ⟸   XM_021252440
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000001264   ⟸   ENSHGLT00000001306


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000985 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001306 ENTREZGENE
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro TF_GATA-2/3 UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report hgl:101703409 UniProtKB/TrEMBL
NCBI Gene Gata2 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
  PTHR10071:SF149 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
PIRSF TF_GATA-1/2/3 UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt G5BII6 ENTREZGENE, UniProtKB/TrEMBL