Nr4a3 (nuclear receptor subfamily 4 group A member 3) - Rat Genome Database

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Pathways
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Gene: Nr4a3 (nuclear receptor subfamily 4 group A member 3) Heterocephalus glaber
Analyze
Symbol: Nr4a3
Name: nuclear receptor subfamily 4 group A member 3
RGD ID: 18931307
Description: ENCODES a protein that exhibits cAMP response element binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adult behavior (ortholog); animal organ regeneration (ortholog); axon guidance (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); congenital myasthenic syndrome 14 (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
animal organ regeneration  (ISO)
axon guidance  (ISO)
cellular respiration  (ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to corticotropin-releasing hormone stimulus  (IEA)
cellular response to leptin stimulus  (ISO)
common myeloid progenitor cell proliferation  (ISO)
dendritic cell apoptotic process  (ISO)
energy homeostasis  (ISO)
fat cell differentiation  (ISO)
gastrulation  (ISO)
hippocampus development  (ISO)
inner ear morphogenesis  (ISO)
intracellular receptor signaling pathway  (IEA)
intracellular signal transduction  (ISO)
mast cell degranulation  (ISO)
mesoderm formation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular process controlling balance  (ISO)
neuron apoptotic process  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway  (ISO)
positive regulation of mast cell cytokine production  (ISO)
positive regulation of monocyte aggregation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of smooth muscle cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
regulation of type B pancreatic cell proliferation  (ISO)
response to hydrogen peroxide  (ISO)
response to peptide hormone  (ISO)
semicircular canal morphogenesis  (ISO)
smooth muscle cell apoptotic process  (ISO)
vestibular reflex  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nr4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,098,915 - 1,141,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NR4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,821,885 - 99,866,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,821,855 - 99,866,891 (+)EnsemblGRCh38hg38GRCh38
GRCh379102,584,167 - 102,629,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,623,958 - 101,668,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 34999,668,563 - 99,708,728NCBI
Celera973,097,532 - 73,142,572 (+)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,183,339 - 72,228,487 (+)NCBIHuRef
CHM1_19102,730,616 - 102,775,645 (+)NCBICHM1_1
T2T-CHM13v2.09111,993,520 - 112,038,527 (+)NCBIT2T-CHM13v2.0
Nr4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,045,098 - 48,086,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm39 Ensembl
GRCm38448,045,078 - 48,086,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,045,153 - 48,086,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37448,064,120 - 48,096,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,072,348 - 48,104,452 (+)NCBIMGSCv36mm8
Celera448,073,263 - 48,105,416 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.07NCBI
Nr4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,157,141 - 67,198,287 (+)NCBIGRCr8
mRatBN7.2562,361,588 - 62,401,489 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,361,822 - 62,402,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,336,680 - 64,376,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,155,972 - 66,195,731 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,125,439 - 66,165,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,781,801 - 63,822,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,781,801 - 63,821,637 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,298,772 - 68,339,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,713,468 - 64,753,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,718,506 - 64,758,343 (+)NCBI
Celera565,193,786 - 65,233,628 (-)NCBICelera
Cytogenetic Map5q22NCBI
Nr4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,779,178 - 25,818,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,779,368 - 25,817,445 (-)NCBIChiLan1.0ChiLan1.0
NR4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21139,597,195 - 39,640,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1939,599,566 - 39,642,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,907,056 - 70,950,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,028,151 - 99,049,949 (+)NCBIpanpan1.1PanPan1.1panPan2
NR4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,806,506 - 56,846,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,812,804 - 56,847,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,238,295 - 55,278,535 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01157,915,798 - 57,956,020 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,915,647 - 57,955,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,420,068 - 56,460,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,444,924 - 56,485,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,144,349 - 57,184,553 (+)NCBIUU_Cfam_GSD_1.0
Nr4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,704,489 - 171,743,204 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,252,381 - 8,289,157 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,252,321 - 8,290,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,570,010 - 241,611,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11241,569,867 - 241,611,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,813,286 - 269,852,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,568,085 - 39,611,704 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,567,852 - 39,606,837 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660352,937,605 - 2,981,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000003262   ⟹   ENSHGLP00000003207
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,141,446 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000003263   ⟹   ENSHGLP00000003208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248251,097,432 - 1,136,615 (-)Ensembl
RefSeq Acc Id: XM_004864935   ⟹   XP_004864992
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248251,098,915 - 1,141,351 (-)NCBI
RefSeq Acc Id: XM_021244549   ⟹   XP_021100208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248251,098,915 - 1,141,351 (-)NCBI
RefSeq Acc Id: XM_021244550   ⟹   XP_021100209
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248251,098,915 - 1,141,351 (-)NCBI
RefSeq Acc Id: XM_021244551   ⟹   XP_021100210
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248251,098,915 - 1,139,315 (-)NCBI
RefSeq Acc Id: XM_021244552   ⟹   XP_021100211
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248251,122,887 - 1,141,373 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004864992   ⟸   XM_004864935
- Peptide Label: isoform X1
- UniProtKB: G5AZ32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100209   ⟸   XM_021244550
- Peptide Label: isoform X1
- UniProtKB: G5AZ32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100208   ⟸   XM_021244549
- Peptide Label: isoform X1
- UniProtKB: G5AZ32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100210   ⟸   XM_021244551
- Peptide Label: isoform X1
- UniProtKB: G5AZ32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100211   ⟸   XM_021244552
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000003208   ⟸   ENSHGLT00000003263
RefSeq Acc Id: ENSHGLP00000003207   ⟸   ENSHGLT00000003262


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002383 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003262 ENTREZGENE
  ENSHGLT00000003263 ENTREZGENE
Gene3D-CATH Erythroid Transcription Factor GATA-1, subunit A UniProtKB/TrEMBL
  Retinoid X Receptor UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  NOR1_rcpt UniProtKB/TrEMBL
  Nuc_orph_rcpt UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr4a3 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3 UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS NORNUCRECPTR UniProtKB/TrEMBL
  NUCLEARECPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  Nuclear receptor ligand-binding domain UniProtKB/TrEMBL
UniProt G5AZ32 ENTREZGENE, UniProtKB/TrEMBL