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ONTOLOGY REPORT - ANNOTATIONS


Term:leukocyte degranulation
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Accession:GO:0043299 term browser browse the term
Definition:The regulated exocytosis of secretory granules by a leukocyte.
Synonyms:exact_synonym: immune cell degranulation;   immune cell granule exocytosis;   leucocyte degranulation;   leukocyte granule exocytosis


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basophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha JBrowse link 1 261,337,594 261,362,509 RGD:2306407
cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
eosinophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:1624291
RGD:1600115
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:8553828
RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1624291
histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07053516.1 RGD:1600115
G Adora3 adenosine A3 receptor JBrowse link 2 208,336,909 208,379,217 RGD:1624291
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1600535
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1578516
G Snap23 synaptosome associated protein 23 JBrowse link 3 112,333,972 112,362,960 RGD:1624291
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:1625716
mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:11576314
G Chga chromogranin A JBrowse link 6 126,434,226 126,445,569 RGD:1600115
RGD:1624291
G Clnk cytokine-dependent hematopoietic cell linker JBrowse link 14 76,657,165 76,834,050 RGD:1624291
G Cplx2 complexin 2 JBrowse link 17 10,756,871 10,828,811 RGD:1600115
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:1624291
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1600115
G Lat2 linker for activation of T cells family, member 2 JBrowse link 12 25,114,099 25,128,381 RGD:1600115
G Milr1 mast cell immunoglobulin-like receptor 1 JBrowse link 10 94,944,243 94,961,795 RGD:1624291
RGD:1600115
G Mrgprx2 MAS related GPR family member X2 JBrowse link 1 103,743,746 103,760,945 RGD:1624291
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:1624291
RGD:1600115
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1624291
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Tac4 tachykinin precursor 4 JBrowse link 10 83,081,168 83,089,487 RGD:1600115
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1624291
RGD:1600115
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
negative regulation of eosinophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr2 C-C motif chemokine receptor 2 RGD:1624291
RGD:1600115
negative regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Cd84 CD84 molecule JBrowse link 13 90,241,369 90,283,625 RGD:1624291
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:1624291
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1601626
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:1624291
RGD:1600115
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abr ABR activator of RhoGEF and GTPase JBrowse link 10 64,565,121 64,657,079 RGD:1624291
RGD:1600115
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:1624291
neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa3 annexin A3 JBrowse link 14 14,371,921 14,426,503 RGD:1624291
G Myo1f myosin IF JBrowse link 7 18,440,742 18,491,448 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:1600115
RGD:1624291
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:1624291
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:8553828
RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1624291
positive regulation of eosinophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Stx4 syntaxin 4 JBrowse link 1 199,287,384 199,295,606 RGD:1600115
RGD:1624291
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:13461752
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1624291
G Snx4 sorting nexin 4 JBrowse link 11 70,693,381 70,753,620 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1600115
RGD:1624291
positive regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:1624291
RGD:1600115
G Adora3 adenosine A3 receptor JBrowse link 2 208,336,909 208,379,217 RGD:1624291
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 10 92,191,473 92,233,662 RGD:5130941
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:1624291
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
RGD:1600115
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:1624291
RGD:1600115
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:9587812
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:9587812
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
RGD:13792537
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Ms4a2 membrane spanning 4-domains A2 JBrowse link 1 227,957,363 227,965,312 RGD:1578516
G Nppc natriuretic peptide C JBrowse link 9 93,731,436 93,735,636 RGD:13461752
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:2299903
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:12904029
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:12904029
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:2299903
RGD:13792537
RGD:1600115
RGD:1624291
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
positive regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd177 CD177 molecule JBrowse link 1 82,964,683 82,987,306 RGD:1624291
RGD:13792537
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1624291
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1624291
G LOC100909620 CD177 antigen-like JBrowse link 1 81,555,412 81,560,629 RGD:13792537
G LOC100909700 CD177 antigen-like JBrowse link 1 81,609,177 81,627,763 RGD:13792537
G LOC100910565 CD177 antigen-like JBrowse link 1 81,548,679 81,551,288 RGD:13792537
G LOC100910611 CD177 antigen-like JBrowse link 1 81,564,683 81,584,541 RGD:13792537
G LOC100910953 CD177 antigen-like JBrowse link 1 82,815,709 82,820,487 RGD:13792537
G LOC102553892 CD177 antigen-like JBrowse link 1 82,947,303 82,952,884 RGD:13792537
G Ptafr platelet-activating factor receptor JBrowse link 5 150,746,284 150,775,675 RGD:10041060
G RGD1564380 similar to BC049730 protein JBrowse link 1 82,830,153 82,902,864 RGD:13792537
G RGD1565655 similar to BC049730 protein JBrowse link 1 81,592,004 81,597,637 RGD:13792537
regulation of histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snx6 sorting nexin 6 JBrowse link 6 75,626,927 75,670,172 RGD:1624291
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:1624291
regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blk BLK proto-oncogene, Src family tyrosine kinase JBrowse link 15 46,555,552 46,593,778 RGD:13792537
G Fer FER tyrosine kinase JBrowse link 9 111,557,804 111,868,583 RGD:13792537
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:1624291
RGD:13792537
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:13792537
RGD:1600115
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:1624291
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed JBrowse link 4 159,483,089 159,518,387 RGD:10047193
RGD:13792537
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:2312429
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1600115
RGD:1624291
regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pram1 PML-RARA regulated adaptor molecule 1 JBrowse link 7 18,507,878 18,516,321 RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:1624291
serotonin secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    immune system process 2798
      immune effector process 877
        leukocyte degranulation 89
          basophil degranulation + 1
          cytotoxic T cell degranulation + 3
          eosinophil degranulation + 7
          mast cell degranulation + 58
          natural killer cell degranulation + 11
          negative regulation of leukocyte degranulation + 12
          neutrophil degranulation + 24
          positive regulation of leukocyte degranulation + 42
          regulation of leukocyte degranulation + 65
Path 2
Term Annotations click to browse term
  biological_process 19858
    localization 6457
      establishment of localization 4905
        transport 4762
          export from cell 1112
            secretion by cell 1061
              exocytosis 426
                regulated exocytosis 294
                  leukocyte degranulation 89
                    basophil degranulation + 1
                    cytotoxic T cell degranulation + 3
                    eosinophil degranulation + 7
                    mast cell degranulation + 58
                    natural killer cell degranulation + 11
                    negative regulation of leukocyte degranulation + 12
                    neutrophil degranulation + 24
                    positive regulation of leukocyte degranulation + 42
                    regulation of leukocyte degranulation + 65
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.