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ONTOLOGY REPORT - ANNOTATIONS

Term:leukocyte degranulation
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Accession:GO:0043299 term browser browse the term
Definition:The regulated exocytosis of secretory granules by a leukocyte.
Synonyms:exact_synonym: immune cell degranulation;   immune cell granule exocytosis;   leucocyte degranulation;   leukocyte granule exocytosis
 only_in_taxon: NCBITaxon:7742 ! Vertebrata


show annotations for term's descendants           Sort by:
basophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha IMP RGD PMID:17122963 RGD:2306407 NCBI chr 1:240,902,804...240,929,234
Ensembl chr 1:240,902,855...240,929,337 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO MGI:1856656 (MGI:3653524|PMID:11266473) RGD PMID:11266473 MGI:3653524 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080), (MGI:5471188|PMID:23190531) RGD PMID:23042080 PMID:23190531 MGI:5460953 MGI:5471188 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10706735)		 UniProt
RGD		 PMID:10706735 GO_REF:0000024 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Fcer1a Fc epsilon receptor Ia involved_in ISO (PMID:8114916) RGD PMID:8114916 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon involved_in ISO (PMID:8114916) RGD PMID:8114916
G Vamp2 vesicle-associated membrane protein 2 involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO
IDA		 (PMID:16677249)
PMID:14993220		 RGD PMID:16677249 PMID:14993220 RGD:8553828 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 NOT|involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:12220673 RGD:1600535 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IMP RGD PMID:16177098 RGD:1578516 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO MGI:6695900 (MGI:6693988|PMID:32238914) RGD PMID:32238914 MGI:6693988 NCBI chr20:7,164,576...7,198,473
Ensembl chr20:7,164,720...7,198,468 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 involved_in ISO
IEA		 (MGI:1351429|PMID:10618388)
GO_REF:0000107		 RGD
Ensembl		 PMID:10618388 GO_REF:0000107 MGI:1351429 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Snap23 synaptosome associated protein 23 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18253931)		 Ensembl
RGD		 PMID:18253931 GO_REF:0000107 NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta IMP RGD PMID:12499633 RGD:1625716 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(MGI:3776334|PMID:11454903)		 Ensembl
RGD		 PMID:11454903 GO_REF:0000107 MGI:3776334 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Cbl Cbl proto-oncogene IEP RGD PMID:18243321 RGD:11576314 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cd300a Cd300a molecule acts_upstream_of ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Chga chromogranin A involved_in ISS
ISO		 GO_REF:0000024
(PMID:21214543)		 UniProt
RGD		 PMID:21214543 GO_REF:0000024 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Clnk cytokine-dependent hematopoietic cell linker involved_in ISO (MGI:2179131|PMID:10744659) RGD PMID:10744659 MGI:2179131 NCBI chr14:71,923,894...72,101,180
Ensembl chr14:71,873,105...72,101,208 		JBrowse link
G Cplx2 complexin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of
involved_in		 ISO (MGI:85068|PMID:9000133)
(PMID:8551243)		 RGD PMID:8551243 PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand involved_in ISS
ISO		 GO_REF:0000024
(PMID:35704588)		 UniProt
RGD		 PMID:35704588 GO_REF:0000024 NCBI chr16:12,868,270...12,875,876
Ensembl chr16:12,868,270...12,875,876 		JBrowse link
G Grp gastrin releasing peptide involved_in ISS
ISO		 GO_REF:0000024
(MGI:6872268|PMID:21933692)		 UniProt
RGD		 PMID:21933692 GO_REF:0000024 MGI:6872268 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon involved_in ISO (PMID:33840121), (PMID:8551243) RGD PMID:8551243 PMID:33840121
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in ISO (PMID:20100931) RGD PMID:20100931 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lat linker for activation of T cells involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288 		JBrowse link
G Milr1 mast cell immunoglobulin-like receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4461821|PMID:20526344)		 UniProt
RGD		 PMID:20526344 GO_REF:0000024 MGI:4461821 NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 involved_in ISO (PMID:22069323) RGD PMID:22069323 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISO
ISS		 (MGI:5586645|PMID:24586680)
GO_REF:0000024		 RGD
UniProt		 PMID:24586680 GO_REF:0000024 MGI:5586645 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within ISO MGI:4461174 (MGI:5492190|PMID:23624557) RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Ptgdrl1 prostaglandin D2 receptor-like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:18,074,153...18,081,335
Ensembl chr15:18,072,361...18,081,437 		JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO MGI:6695900 (MGI:6693988|PMID:32238914) RGD PMID:32238914 MGI:6693988 NCBI chr20:7,164,576...7,198,473
Ensembl chr20:7,164,720...7,198,468 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 acts_upstream_of_or_within ISO MGI:2386261 (MGI:3758152|PMID:17190838) RGD PMID:17190838 MGI:3758152 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO
IEA		 MGI:5608917 (MGI:6362506|PMID:31534133)
GO_REF:0000107		 RGD
Ensembl		 PMID:31534133 GO_REF:0000107 MGI:6362506 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)		 Ensembl
RGD		 PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tac4 tachykinin precursor 4 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:80,207,824...80,216,156
Ensembl chr10:80,207,610...80,216,156 		JBrowse link
natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (PMID:25786175), (PMID:28652325) RGD PMID:25786175 PMID:28652325 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6506882|PMID:32839608), (MGI:6810811|PMID:33911019) RGD PMID:32839608 PMID:33911019 MGI:6506882 MGI:6810811 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO MGI:1856656 (MGI:3653524|PMID:11266473) RGD PMID:11266473 MGI:3653524 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080), (MGI:5471188|PMID:23190531) RGD PMID:23042080 PMID:23190531 MGI:5460953 MGI:5471188 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Unc13d unc-13 homolog D acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:3628822 (MGI:3703574|PMID:17420270)
GO_REF:0000107		 RGD
Ensembl		 PMID:17420270 GO_REF:0000107 MGI:3703574 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:18042464) RGD PMID:18042464 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18042464) RGD PMID:18042464 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18424730)		 UniProt
RGD		 PMID:18424730 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) RGD PMID:32647003 NCBI chr 7:134,577,443...134,622,934
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
negative regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3699670|PMID:14662900)		 BHF-UCL
RGD		 PMID:14662900 GO_REF:0000024 MGI:3699670 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule acts_upstream_of_or_within
involved_in		 ISO (MGI:3721168|PMID:12874256)
(PMID:16339535)		 RGD PMID:12874256 PMID:16339535 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd84 CD84 molecule involved_in ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:2179135 (MGI:4367570|PMID:18421012) RGD PMID:18421012 MGI:4367570 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2653910 (MGI:3589858|PMID:15944273)		 Ensembl
RGD		 PMID:15944273 GO_REF:0000107 MGI:3589858 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
negative regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:88141 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:107771 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6381024|PMID:30911105) RGD PMID:30911105 MGI:6381024 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of ISO MGI:88141 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505 		JBrowse link
G Anxa3 annexin A3 involved_in ISO (PMID:9550422) RGD PMID:9550422 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of ISO MGI:107771 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Myo1f myosin IF acts_upstream_of_or_within ISO MGI:3664779 (MGI:3664353|PMID:17023661) RGD PMID:17023661 MGI:3664353 NCBI chr 7:14,363,340...14,413,911
Ensembl chr 7:14,363,350...14,413,911 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing NOT|involved_in ISO (MGI:6103777|PMID:28779020) RGD PMID:28779020 MGI:6103777 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080) RGD PMID:23042080 MGI:5460953 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Stxbp2 syntaxin binding protein 2 involved_in ISO (PMID:18588921) RGD PMID:18588921 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in ISO (PMID:18588921) RGD PMID:18588921 NCBI chr 2:196,442,738...196,485,733
Ensembl chr 2:196,442,634...196,485,671 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in IDA
ISO		 PMID:14993220
(PMID:16677249)		 RGD PMID:16677249 PMID:14993220 RGD:8553828 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 NOT|involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11714832) RGD PMID:11714832 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Stx4 syntaxin 4 involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979 		JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (MGI:5492190|PMID:23624557)
(PMID:23624557)		 RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18253931)		 Ensembl
RGD		 PMID:18253931 GO_REF:0000107 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3776334|PMID:11454903)		 Ensembl
RGD		 PMID:11454903 GO_REF:0000107 MGI:3776334 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5294498|PMID:21746961)		 UniProt
RGD		 PMID:21746961 GO_REF:0000024 MGI:5294498 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISO
ISS		 (MGI:2137187|PMID:11449275)
GO_REF:0000024		 RGD
UniProt		 PMID:11449275 GO_REF:0000024 MGI:2137187 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO MGI:1931804|MGI:96556 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1857195|MGI:96541 (MGI:3589858|PMID:15944273)		 RGD PMID:15944273 PMID:21873635 MGI:3589858, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:1861951 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310 		JBrowse link
G Nppc natriuretic peptide C involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IMP
IEA
ISO
IBA		 GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)
PMID:21873635		 Ensembl
RGD		 PMID:9000133 PMID:16861349 PMID:21873635 GO_REF:0000107 MGI:85068, RGD:2299903, RGD:13792537 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:37,744,666...37,831,131
Ensembl chr19:37,744,633...37,829,167 		JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Klrc2 killer cell lectin like receptor C2 involved_in ISO (PMID:21825173) RGD PMID:21825173 NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA		 (PMID:23632890)
GO_REF:0000107		 RGD
Ensembl		 PMID:23632890 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:3,403,418...3,479,476 JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in IBA
ISO		 PMID:21873635
UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407)		 RGD PMID:21193407 PMID:21873635 RGD:13792537 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Lypd10 Ly6/PLAUR domain containing 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:80,273,019...80,278,238
Ensembl chr 1:80,273,019...80,278,219 		JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:2829894 RGD:10041060 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G RGD1565655 similar to BC049730 protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:80,323,188...80,328,311
Ensembl chr 1:80,323,863...80,328,311 		JBrowse link
regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx6 sorting nexin 6 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vamp3 vesicle-associated membrane protein 3 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 5:161,498,109...161,508,704
Ensembl chr 5:161,498,109...161,508,751 		JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fer FER tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase involved_in IBA
ISO		 PMID:21873635
(PMID:19001085)		 RGD PMID:19001085 PMID:21873635 RGD:13792537 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO
IBA
ISS		 (MGI:3703139|PMID:16272347)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:16272347 PMID:21873635 GO_REF:0000024 MGI:3703139, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (MGI:5298334|PMID:21063107) RGD PMID:21063107 MGI:5298334 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (MGI:3655336|PMID:10843388) RGD PMID:10843388 MGI:3655336 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed involved_in IBA
IDA		 PMID:21873635
PMID:25122211		 GO_Central
UniProt		 PMID:21873635 PMID:25122211 RGD:13792537, RGD:10047193 NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382 		JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:12482918 RGD:2312429 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO (PMID:15548590) RGD PMID:15548590 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pram1 PML-RARA regulated adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3579812 (MGI:3525750|PMID:15572693) RGD PMID:15572693 MGI:3525750 NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA
ISS		 (MGI:4414596|PMID:19797524)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19797524 GO_REF:0000024 GO_REF:0000107 MGI:4414596 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule acts_upstream_of_or_within ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 involved_in ISO
IEA		 (MGI:1351429|PMID:10618388)
GO_REF:0000107		 RGD
Ensembl		 PMID:10618388 GO_REF:0000107 MGI:1351429 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    immune system process 2582
      immune effector process 676
        leukocyte degranulation 95
          basophil degranulation + 1
          cytotoxic T cell degranulation + 4
          eosinophil degranulation + 9
          mast cell degranulation + 64
          natural killer cell degranulation + 14
          negative regulation of leukocyte degranulation + 14
          neutrophil degranulation + 20
          positive regulation of leukocyte degranulation + 37
          regulation of leukocyte degranulation + 58
Path 2
Term Annotations click to browse term
  biological_process 19746
    localization 5598
      establishment of localization 4939
        transport 4766
          export from cell 1068
            secretion by cell 989
              exocytosis 399
                regulated exocytosis 278
                  leukocyte degranulation 95
                    basophil degranulation + 1
                    cytotoxic T cell degranulation + 4
                    eosinophil degranulation + 9
                    mast cell degranulation + 64
                    natural killer cell degranulation + 14
                    negative regulation of leukocyte degranulation + 14
                    neutrophil degranulation + 20
                    positive regulation of leukocyte degranulation + 37
                    regulation of leukocyte degranulation + 58
paths to the root