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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 3 signaling pathway
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Accession:GO:0034138 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3.
Synonyms:exact_synonym: TLR3 signaling pathway;   toll-like receptor 3 signalling pathway

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toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule involved_in ISO (MGI:5645190|PMID:25158758) UniProt PMID:25158758 MGI:5645190 NCBI chrNW_004624912:350,201...432,410
Ensembl chrNW_004624912:350,157...426,712 		JBrowse link
G Colec12 collectin subfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624770:10,860,097...11,136,478
Ensembl chrNW_004624770:10,859,205...11,013,175 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chrNW_004624733:32,521,318...32,527,499 JBrowse link
G Lgals9 galectin 9 involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chrNW_004624786:478,048...491,086 JBrowse link
G Oas1 2'-5'-oligoadenylate synthetase 1 involved_in ISO (PMID:30078389) ARUK-UCL PMID:30078389 NCBI chrNW_004624747:19,428,994...19,434,512
Ensembl chrNW_004624747:19,428,833...19,434,550 		JBrowse link
G Rftn1 raftlin, lipid raft linker 1 acts_upstream_of_or_within ISO (PMID:21266579) MGI PMID:21266579 NCBI chrNW_004624821:1,561,845...1,763,654
Ensembl chrNW_004624821:1,562,778...1,751,345 		JBrowse link
G Scara3 scavenger receptor class A member 3 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004624758:22,454,181...22,488,431
Ensembl chrNW_004624758:22,454,213...22,488,452 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:8,975,216...8,982,825
Ensembl chrNW_004624786:8,974,587...9,007,986 		JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:12471095) UniProt PMID:12471095 NCBI chrNW_004624828:4,964,199...4,973,465
Ensembl chrNW_004624828:4,971,093...4,973,198 		JBrowse link
G Tlr3 toll like receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624769:16,925,969...16,945,250
Ensembl chrNW_004624769:16,925,984...16,941,196 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in ISO (MGI:3656197|PMID:16633345) UniProt PMID:16633345 MGI:3656197 NCBI chrNW_004624755:24,976,375...24,995,150
Ensembl chrNW_004624755:24,976,361...25,001,397 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624767:18,859,990...18,869,083
Ensembl chrNW_004624767:18,860,017...18,868,581 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) UniProt PMID:19865078 NCBI chrNW_004624869:1,326,605...1,337,195 JBrowse link
G Rnf170 ring finger protein 170 involved_in ISO (PMID:31076723) UniProt PMID:31076723 NCBI chrNW_004624780:67,160...127,620
Ensembl chrNW_004624780:66,049...126,383 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISO (MGI:5619743|PMID:21695056) CACAO PMID:21695056 MGI:5619743 NCBI chrNW_004624809:6,434,842...6,487,442
Ensembl chrNW_004624809:6,436,658...6,487,251 		JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004624827:2,844,855...2,878,367
Ensembl chrNW_004624827:2,844,115...2,879,179 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) UniProt PMID:19865078 NCBI chrNW_004624869:1,326,605...1,337,195 JBrowse link
G Flot1 flotillin 1 involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004624754:24,992,961...25,000,463
Ensembl chrNW_004624754:24,992,929...25,003,759 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:19734906) MGI PMID:19734906 NCBI chrNW_004624762:9,328,275...9,382,996
Ensembl chrNW_004624762:9,328,109...9,386,067 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (MGI:4943396|PMID:17322885) BHF-UCL PMID:17322885 MGI:4943396 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
G Trim3 tripartite motif containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624817:7,965,976...7,991,426
Ensembl chrNW_004624817:7,965,976...7,991,411 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624823:1,353,601...1,405,762
Ensembl chrNW_004624823:1,353,621...1,401,160 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004624786:1,449,001...1,465,208
Ensembl chrNW_004624786:1,450,234...1,465,102 		JBrowse link
G Hcfc2 host cell factor C2 acts_upstream_of_or_within ISO (PMID:28970238) MGI PMID:28970238 NCBI chrNW_004624750:4,627,848...4,660,448
Ensembl chrNW_004624750:4,629,669...4,660,413 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:37158982) UniProt PMID:37158982 NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14237
      signal transduction 5415
        intracellular receptor signaling pathway 340
          cytoplasmic pattern recognition receptor signaling pathway 151
            endolysosomal toll-like receptor signaling pathway 44
              toll-like receptor 3 signaling pathway 26
                negative regulation of toll-like receptor 3 signaling pathway 3
                positive regulation of toll-like receptor 3 signaling pathway 8
                regulation of toll-like receptor 3 signaling pathway + 13
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to biotic stimulus 1361
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          pattern recognition receptor signaling pathway 235
                            cytoplasmic pattern recognition receptor signaling pathway 151
                              endolysosomal toll-like receptor signaling pathway 44
                                toll-like receptor 3 signaling pathway 26
                                  negative regulation of toll-like receptor 3 signaling pathway 3
                                  positive regulation of toll-like receptor 3 signaling pathway 8
                                  regulation of toll-like receptor 3 signaling pathway + 13
paths to the root