Oas1 (2'-5'-oligoadenylate synthetase 1) - Rat Genome Database

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Gene: Oas1 (2'-5'-oligoadenylate synthetase 1) Heterocephalus glaber
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Symbol: Oas1
Name: 2'-5'-oligoadenylate synthetase 1
RGD ID: 18900150
Description: ENCODES a protein that exhibits 2'-5'-oligoadenylate synthetase activity (ortholog); INVOLVED IN cellular response to interferon-alpha (ortholog); cellular response to interferon-beta (ortholog); glucose homeostasis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Human Influenza (ortholog); IMMUNODEFICIENCY 100 WITH PULMONARY ALVEOLAR PROTEINOSIS AND HYPOGAMMAGLOBULINEMIA (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog); ribosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 2'-5'-oligoadenylate synthase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,428,833 - 19,434,550 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,428,994 - 19,434,512 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
mitochondrion  (ISO)
nucleoplasm  (IEA)
nucleus  (ISO)
ribosome  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Oas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,428,833 - 19,434,550 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,428,994 - 19,434,512 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
OAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,906,962 - 112,933,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,905,856 - 112,933,219 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,344,767 - 113,371,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,829,122 - 111,842,095 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,807,531 - 111,820,427NCBI
Celera12112,971,828 - 112,984,801 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,357,341 - 110,370,314 (+)NCBIHuRef
CHM1_112113,313,139 - 113,326,112 (+)NCBICHM1_1
T2T-CHM13v2.012112,883,649 - 112,909,905 (+)NCBIT2T-CHM13v2.0
Oas1g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,014,205 - 121,025,676 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,014,205 - 121,025,676 (-)EnsemblGRCm39 Ensembl
GRCm385120,876,142 - 120,887,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,876,142 - 120,887,613 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,326,151 - 121,337,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,136,759 - 121,148,215 (-)NCBIMGSCv36mm8
Celera5117,962,394 - 117,973,852 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.65NCBI
Oas1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,330,423 - 41,341,130 (+)NCBIGRCr8
mRatBN7.21235,669,798 - 35,680,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,669,801 - 35,680,517 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,848,682 - 36,859,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,459,883 - 37,470,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,512,331 - 36,522,962 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,200,680 - 41,211,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,200,718 - 41,211,909 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,064,691 - 43,075,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,806,061 - 36,816,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,669,448 - 36,680,110 (+)NCBI
Celera1237,333,307 - 37,343,967 (+)NCBICelera
Cytogenetic Map12q16NCBI
OAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210120,996,177 - 121,009,992 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112120,992,579 - 121,006,388 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,511,984 - 110,525,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,896,687 - 113,922,082 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,896,760 - 113,921,814 (+)Ensemblpanpan1.1panPan2
OAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,385,393 - 10,396,734 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,385,447 - 10,396,733 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,503,053 - 10,513,130 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,624,806 - 10,636,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,624,845 - 10,638,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,598,606 - 10,608,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,661,801 - 10,671,881 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,710,236 - 10,720,322 (+)NCBIUU_Cfam_GSD_1.0
OAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,851,918 - 38,859,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,851,083 - 38,867,427 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,260,747 - 41,268,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,163,203 - 108,176,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,163,299 - 108,176,193 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,898,457 - 136,923,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013071770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01027026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000023046   ⟹   ENSHGLP00000022832
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474719,428,833 - 19,434,550 (-)Ensembl
RefSeq Acc Id: XM_013071770   ⟹   XP_012927224
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474719,428,994 - 19,434,512 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012927224 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022832
RefSeq Acc Id: XP_012927224   ⟸   XM_013071770
- UniProtKB: G5AKV9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000022832   ⟸   ENSHGLT00000023046


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016286 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023046 ENTREZGENE
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/TrEMBL
  Beta Polymerase, domain 2 UniProtKB/TrEMBL
InterPro 2-5-oligoAdlate_synth_1_dom2/C UniProtKB/TrEMBL
  2-5OAS_C_CS UniProtKB/TrEMBL
  2-5OAS_N_CS UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/TrEMBL
  Polymerase_NTP_transf_dom UniProtKB/TrEMBL
NCBI Gene Oas1 ENTREZGENE
PANTHER 2'-5'-OLIGOADENYLATE SYNTHASE 1 UniProtKB/TrEMBL
  2-5 OLIGOADENYLATE SYNTHETASE UniProtKB/TrEMBL
Pfam NTP_transf_2 UniProtKB/TrEMBL
  OAS1_C UniProtKB/TrEMBL
PROSITE 25A_SYNTH_1 UniProtKB/TrEMBL
  25A_SYNTH_2 UniProtKB/TrEMBL
  25A_SYNTH_3 UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidyltransferase UniProtKB/TrEMBL
  PAP/OAS1 substrate-binding domain UniProtKB/TrEMBL
UniProt G5AKV9 ENTREZGENE, UniProtKB/TrEMBL