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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of tumor necrosis factor-mediated signaling pathway
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Accession:GO:0010804 term browser browse the term
Definition:Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: negative regulation of TNF signaling;   negative regulation of TNF-mediated signaling pathway;   negative regulation of tumor necrosis factor-mediated signalling pathway


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negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr17:62,351,663...62,356,220 JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr13:78,794,573...78,823,761
Ensembl chr13:78,794,580...78,822,796 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in
acts_upstream_of		 IEA
ISO		 (PMID:26435691) Ensembl
ARUK-UCL		 PMID:26435691 GO_REF:0000107 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,848,797...78,880,733
Ensembl chr11:78,848,797...78,881,284 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,875...52,667,610 		JBrowse link
G H2BC11 H2B clustered histone 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:21,219,729...21,220,563
Ensembl chr 7:21,220,123...21,220,503 		JBrowse link
G LOC100510975 coiled-coil domain-containing protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:59,052,979...59,144,791
Ensembl chr10:59,052,915...59,144,797 		JBrowse link
G MIR125B-1 microRNA mir-125b-1 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 9:49,109,435...49,109,514
Ensembl chr 9:49,109,435...49,109,514 		JBrowse link
G MIR130A microRNA mir-130a acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 2:13,296,695...13,296,773
Ensembl chr 2:13,296,695...13,296,773 		JBrowse link
G MIR152 microRNA mir-152 involved_in ISO (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336 		JBrowse link
G MIR27B microRNA mir-27b acts_upstream_of_or_within ISO (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr10:27,079,963...27,080,042
Ensembl chr10:27,079,954...27,080,056 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr16:47,700,869...47,710,036 JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:59,186,265...59,186,402 JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24113711)
(PMID:23950925)		 MGI
Ensembl		 PMID:23950925 PMID:24113711 GO_REF:0000107 NCBI chr 2:5,950,552...5,959,786
Ensembl chr 2:5,948,849...5,959,734 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr 2:74,702,915...74,729,792
Ensembl chr 2:74,702,945...74,729,775 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28159925) ARUK-UCL
Ensembl		 PMID:28159925 GO_REF:0000107 NCBI chr15:54,295,786...54,325,220
Ensembl chr15:54,296,113...54,325,213 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:40,075,259...40,151,034
Ensembl chr12:40,075,337...40,151,043 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:67,970,972...68,048,681
Ensembl chr15:67,952,173...68,048,963 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125 		JBrowse link
G TRAIP TRAF interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:32,332,336...32,380,988
Ensembl chr13:32,345,599...32,379,766 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:101,399,374...101,440,021
Ensembl chr  X:101,399,812...101,440,013 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    negative regulation of biological process 5654
      negative regulation of response to stimulus 1841
        negative regulation of response to cytokine stimulus 97
          negative regulation of cytokine-mediated signaling pathway 92
            negative regulation of tumor necrosis factor-mediated signaling pathway 27
Path 2
Term Annotations click to browse term
  biological_process 17805
    biological regulation 12904
      regulation of biological process 12537
        signaling 7507
          signal transduction 6963
            cell surface receptor signaling pathway 2809
              cytokine-mediated signaling pathway 498
                regulation of cytokine-mediated signaling pathway 158
                  negative regulation of cytokine-mediated signaling pathway 92
                    negative regulation of tumor necrosis factor-mediated signaling pathway 27
paths to the root