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ONTOLOGY REPORT - ANNOTATIONS

Term:G protein-coupled serotonin receptor activity
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Accession:GO:0004993 term browser browse the term
Definition:Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
Synonyms:exact_synonym: 5-HT receptor;   5-hydroxytryptamine receptor
 alt_id: GO:0001585;   GO:0016609
 xref: Wikipedia:5-HT_receptor


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G protein-coupled serotonin receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:10,545,488...10,550,029 JBrowse link
G Drd4 dopamine receptor D4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:205,825,937...205,829,124 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A enables IMP
IBA
ISO
IEA
IDA		 GO_REF:0000033
(PMID:8254366), (PMID:9826725)
GO_REF:0000002
(PMID:22957663), (PMID:8393041)		 GO_Central
RGD
InterPro		 PMID:8254366 PMID:8393041 PMID:9826725 PMID:22957663 PMID:12149253 More... GO_REF:0000002 GO_REF:0000033, RGD:730812, RGD:2303617 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:17325130)
(PMID:1315531)		 GO_Central
RGD		 PMID:1315531 PMID:17325130 PMID:15328035 GO_REF:0000033 MGI:64075, RGD:1358659 NCBI chr 8:91,395,405...91,414,815 JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D enables ISO
IBA
ISS		 (PMID:1652050)
GO_REF:0000033
(PMID:1557407)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:1557407 PMID:1652050 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:153,939,735...153,960,012 JBrowse link
G Htr1f 5-hydroxytryptamine receptor 1F enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:21422162), (PMID:8380639)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:8380639 PMID:21422162 GO_REF:0000024 GO_REF:0000033 NCBI chr11:16,089,266...16,090,665 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A enables ISO
IBA		 (PMID:15862800)
GO_REF:0000033
(PMID:15862800), (PMID:7582481)		 RGD
GO_Central		 PMID:7582481 PMID:15862800 GO_REF:0000033 NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:17325130)
(PMID:15862800)
(PMID:12970106), (PMID:15625277), (PMID:15862800), (PMID:7582481), (PMID:7926008)		 UniProt
GO_Central
RGD		 PMID:7582481 PMID:7926008 PMID:12970106 PMID:15625277 PMID:15862800 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 9:94,184,442...94,206,851 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C enables IMP
IBA
ISO
IEA		 GO_REF:0000033
(PMID:21835345)
GO_REF:0000002
(PMID:12970106), (PMID:7582481)		 GO_Central
RGD
InterPro		 PMID:7582481 PMID:12970106 PMID:21835345 PMID:15663485 GO_REF:0000002 GO_REF:0000033, RGD:1358734 NCBI chr  X:115,453,190...115,682,325 JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 enables IMP
IBA
ISO
ISS
IEA		 GO_REF:0000033
(PMID:10821780), (PMID:16102731), (PMID:35714614), (PMID:9603189)
GO_REF:0000024
(PMID:33299969)
GO_REF:0000107
GO_REF:0000002		 GO_Central
RGD
UniProt
Ensembl
InterPro		 PMID:9603189 PMID:10821780 PMID:16102731 PMID:33299969 PMID:35714614 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:729213, RGD:729350 NCBI chr18:58,036,277...58,221,327 JBrowse link
G Htr5a 5-hydroxytryptamine receptor 5A enables IMP
IBA
ISO		 GO_REF:0000033
(PMID:7988681)		 GO_Central
RGD		 PMID:7988681 PMID:7682702 GO_REF:0000033, RGD:62385 NCBI chr 4:8,178,802...8,188,485 JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B enables ISO
IBA		 (PMID:8450829)
GO_REF:0000033		 RGD
GO_Central		 PMID:8450829 GO_REF:0000033 NCBI chr13:35,239,662...35,252,586 JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:11406289)
(PMID:35714614), (PMID:36989299), (PMID:37327704)
GO_REF:0000002		 GO_Central
RGD
InterPro		 PMID:11406289 PMID:35714614 PMID:36989299 PMID:37327704 PMID:7680751 GO_REF:0000002 GO_REF:0000033, RGD:729174 NCBI chr 5:156,579,901...156,595,147 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000117
(PMID:8394987)
(PMID:35714614), (PMID:8226867)
GO_REF:0000002		 GO_Central
UniProt
RGD
InterPro		 PMID:8226867 PMID:8394987 PMID:35714614 PMID:8394362 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117, RGD:625369 NCBI chr 1:243,049,064...243,173,636 JBrowse link
Gi/o-coupled serotonin receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A enables ISO (PMID:33762731), (PMID:37935376), (PMID:37935377) RGD PMID:33762731 PMID:37935376 PMID:37935377 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B enables ISO (PMID:1348246), (PMID:29925951) RGD PMID:1348246 PMID:29925951 NCBI chr 8:91,395,405...91,414,815 JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D enables ISO (PMID:33762731) RGD PMID:33762731 NCBI chr 5:153,939,735...153,960,012 JBrowse link
G Htr1f 5-hydroxytryptamine receptor 1F enables IEA
ISO		 GO_REF:0000107
(PMID:34239069)		 Ensembl
RGD		 PMID:34239069 GO_REF:0000107 NCBI chr11:16,089,266...16,090,665 JBrowse link
G Htr5a 5-hydroxytryptamine receptor 5A enables ISS
ISO		 GO_REF:0000024
(PMID:35610220), (PMID:35835867), (PMID:9865521)		 UniProt
RGD		 PMID:9865521 PMID:35610220 PMID:35835867 GO_REF:0000024 NCBI chr 4:8,178,802...8,188,485 JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:35,239,662...35,252,586 JBrowse link
Gq/11-coupled serotonin receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2a 5-hydroxytryptamine receptor 2A enables ISO (PMID:18703043), (PMID:35084960) RGD PMID:18703043 PMID:35084960 NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B enables IEA
ISO		 GO_REF:0000107
(PMID:18703043), (PMID:30127358), (PMID:36087581)		 Ensembl
RGD		 PMID:18703043 PMID:30127358 PMID:36087581 GO_REF:0000107 NCBI chr 9:94,184,442...94,206,851 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C enables ISS
ISO		 GO_REF:0000024
(PMID:18703043), (PMID:29398112)		 UniProt
RGD		 PMID:18703043 PMID:29398112 GO_REF:0000024 NCBI chr  X:115,453,190...115,682,325 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21088
    molecular transducer activity 2665
      signaling receptor activity 2665
        transmembrane signaling receptor activity 2416
          G protein-coupled receptor activity 1970
            G protein-coupled amine receptor activity 51
              G protein-coupled serotonin receptor activity 14
                Gi/o-coupled serotonin receptor activity 6
                Gq/11-coupled serotonin receptor activity 3
paths to the root