Htr1f (5-hydroxytryptamine receptor 1F) - Rat Genome Database

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Gene: Htr1f (5-hydroxytryptamine receptor 1F) Rattus norvegicus
Analyze
Symbol: Htr1f
Name: 5-hydroxytryptamine receptor 1F
RGD ID: 71083
Description: Predicted to enable neurotransmitter receptor activity; serotonin binding activity; and transmembrane signaling receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Orthologous to human HTR1F (5-hydroxytryptamine receptor 1F); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-1F; 5-HT1F; 5-hydroxytryptamine (serotonin) receptor 1F; 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled; Htr1eb; serotonin receptor 1F; serotonin receptor gene (similar to Mm Htr1eb)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81116,089,266 - 16,090,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1116,081,053 - 16,274,580 (-)EnsemblGRCr8
mRatBN7.2112,642,751 - 2,644,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,642,751 - 2,644,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1111,238,794 - 11,240,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0114,031,850 - 4,033,249 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0113,136,886 - 3,138,285 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0111,982,113 - 1,983,513 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl111,982,113 - 1,983,513 (-)Ensemblrn6Rnor6.0
Rnor_5.0111,960,208 - 1,961,608 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,260,587 - 2,261,687 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera112,624,797 - 2,626,196 (-)NCBICelera
RGSC_v3.1112,260,586 - 2,261,687 (-)NCBI
Cytogenetic Map11p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
migraine  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
synapse  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Lovenberg TW, etal., Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2184-8.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8380639   PMID:19077678   PMID:19735698   PMID:20833155   PMID:21422162   PMID:21653728   PMID:36471527  


Genomics

Comparative Map Data
Htr1f
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81116,089,266 - 16,090,665 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1116,081,053 - 16,274,580 (-)EnsemblGRCr8
mRatBN7.2112,642,751 - 2,644,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,642,751 - 2,644,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1111,238,794 - 11,240,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0114,031,850 - 4,033,249 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0113,136,886 - 3,138,285 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0111,982,113 - 1,983,513 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl111,982,113 - 1,983,513 (-)Ensemblrn6Rnor6.0
Rnor_5.0111,960,208 - 1,961,608 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,260,587 - 2,261,687 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera112,624,797 - 2,626,196 (-)NCBICelera
RGSC_v3.1112,260,586 - 2,261,687 (-)NCBI
Cytogenetic Map11p12NCBI
HTR1F
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38387,792,706 - 87,993,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl387,792,704 - 87,993,839 (+)Ensemblhg38GRCh38
GRCh37387,841,856 - 88,042,989 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36388,114,416 - 88,125,609 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34388,122,589 - 88,123,690NCBI
Celera388,785,845 - 88,797,020 (+)NCBICelera
Cytogenetic Map3p11.2-p11.1NCBI
HuRef388,045,479 - 88,056,646 (+)NCBIHuRef
CHM1_1387,984,884 - 87,996,051 (+)NCBICHM1_1
T2T-CHM13v2.0387,868,616 - 88,069,681 (+)NCBIT2T-CHM13v2.0
Htr1f
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391664,745,092 - 64,926,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1664,745,092 - 64,926,217 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381664,924,729 - 65,105,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1664,924,729 - 65,105,854 (-)Ensemblmm10GRCm38
MGSCv371664,924,555 - 65,105,610 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361664,866,931 - 65,048,056 (-)NCBIMGSCv36mm8
Celera1665,219,165 - 65,393,158 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1637.1NCBI
Htr1f
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554075,512,124 - 5,632,308 (-)Ensembl
ChiLan1.0NW_0049554075,512,124 - 5,632,458 (-)NCBIChiLan1.0ChiLan1.0
HTR1F
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2287,952,120 - 88,215,265 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1387,956,988 - 88,220,116 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0387,933,394 - 88,196,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1390,045,663 - 90,244,207 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl390,241,126 - 90,242,226 (+)EnsemblpanPan2panpan1.1
HTR1F
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131272,358 - 428,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31273,493 - 427,622 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha31315,319 - 471,313 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.031255,959 - 412,097 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl31257,118 - 258,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.131235,347 - 391,230 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031284,174 - 440,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031587,350 - 743,445 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr1f
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049711,734,860 - 1,871,380 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366101,735,950 - 1,737,050 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366101,735,939 - 1,737,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1F
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13167,956,003 - 168,105,090 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113167,951,444 - 167,987,391 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213178,815,949 - 178,844,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1F
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12288,933,841 - 89,098,040 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604177,582,827 - 77,782,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1f
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247894,380,961 - 4,382,354 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247894,381,022 - 4,382,271 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Htr1f
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17109,522,186 - 109,523,585 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htr1f
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:27
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000000907
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 36 109 24 31 5 39 5 1 159 86 8 103 60 64 26 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000000907   ⟹   ENSRNOP00000000907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,089,103 - 16,224,156 (-)Ensembl
mRatBN7.2 Ensembl112,642,751 - 2,644,150 (-)Ensembl
Rnor_6.0 Ensembl111,982,113 - 1,983,513 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128810   ⟹   ENSRNOP00000102159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,081,053 - 16,274,580 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141494   ⟹   ENSRNOP00000105782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,089,464 - 16,273,797 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142234   ⟹   ENSRNOP00000099763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,085,051 - 16,274,255 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144251   ⟹   ENSRNOP00000106078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,081,053 - 16,116,906 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145091   ⟹   ENSRNOP00000106838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,089,510 - 16,274,580 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160958   ⟹   ENSRNOP00000103525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,085,241 - 16,274,102 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172873   ⟹   ENSRNOP00000110686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,089,387 - 16,274,255 (-)Ensembl
RefSeq Acc Id: NM_021857   ⟹   NP_068629
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,089,266 - 16,090,665 (-)NCBI
mRatBN7.2112,642,751 - 2,644,150 (-)NCBI
Rnor_6.0111,982,113 - 1,983,513 (-)NCBI
Rnor_5.0111,960,208 - 1,961,608 (-)NCBI
RGSC_v3.4112,260,587 - 2,261,687 (-)RGD
Celera112,624,797 - 2,626,196 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068629 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42133 (Get FASTA)   NCBI Sequence Viewer  
  EDL75903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000907
GenBank Protein P30940 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068629   ⟸   NM_021857
- UniProtKB: P30940 (UniProtKB/Swiss-Prot),   G3V626 (UniProtKB/TrEMBL),   A6K4W3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000907   ⟸   ENSRNOT00000000907
Ensembl Acc Id: ENSRNOP00000099763   ⟸   ENSRNOT00000142234
Ensembl Acc Id: ENSRNOP00000106078   ⟸   ENSRNOT00000144251
Ensembl Acc Id: ENSRNOP00000102159   ⟸   ENSRNOT00000128810
Ensembl Acc Id: ENSRNOP00000106838   ⟸   ENSRNOT00000145091
Ensembl Acc Id: ENSRNOP00000103525   ⟸   ENSRNOT00000160958
Ensembl Acc Id: ENSRNOP00000110686   ⟸   ENSRNOT00000172873
Ensembl Acc Id: ENSRNOP00000105782   ⟸   ENSRNOT00000141494
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30940-F1-model_v2 AlphaFold P30940 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71083 AgrOrtholog
BioCyc Gene G2FUF-22318 BioCyc
Ensembl Genes ENSRNOG00000000716 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000907 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT1F_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
NCBI Gene 60448 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR 1D UniProtKB/Swiss-Prot
  ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Htr1f PhenoGen
PRINTS 5HT1FRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000716 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT1F_RAT UniProtKB/Swiss-Prot
  A0ABK0LV94_RAT UniProtKB/TrEMBL
  A6K4W3 ENTREZGENE, UniProtKB/TrEMBL
  G3V626 ENTREZGENE, UniProtKB/TrEMBL
  P30940 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr1f  5-hydroxytryptamine receptor 1F  Htr1f  5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr1f  5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled  Htr1f  5-hydroxytryptamine (serotonin) receptor 1F  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Htr1f  5-hydroxytryptamine (serotonin) receptor 1F      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs binds 125I-labeled d-lysergic acid diethylamide (LSD) 70767
gene_protein 366 amino acids 70767