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Term:transmembrane signaling receptor activity
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Accession:GO:0004888 term browser browse the term
Definition:Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comment:This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
Synonyms:exact_synonym: transmembrane signalling receptor activity
 broad_synonym: transmembrane receptor activity
 alt_id: GO:0004926;   GO:0099600
 xref: reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"

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      molecular_function 20701
        molecular transducer activity 2647
          signaling receptor activity 2647
            transmembrane signaling receptor activity 2446
              G protein-coupled receptor activity + 1948
              GABA receptor activity + 22
              ICAM-3 receptor activity 2
              MHC class I receptor activity + 8
              MHC class II receptor activity 1
              MHC class Ib receptor activity + 5
              Wnt receptor activity 16
              acetylcholine receptor activity + 18
              apolipoprotein A-I receptor activity 2
              axon guidance receptor activity 9
              collagen receptor activity + 7
              complement receptor activity + 12
              cytokine receptor activity + 96
              cytokinin receptor activity + 0
              death receptor activity + 9
              glutamate receptor activity + 29
              hedgehog receptor activity 3
              immunoglobulin receptor activity + 10
              latrotoxin receptor activity 1
              mechanoreceptor activity 0
              netrin receptor activity + 6
              neuregulin receptor activity 3
              neurotensin receptor activity, non-G protein-coupled 1
              non-tyrosine kinase fibroblast growth factor receptor activity 0
              nucleotide receptor activity + 20
              olfactory receptor activity + 1401
              opsonin receptor activity + 3
              osmosensor activity + 5
              reelin receptor activity 2
              semaphorin receptor activity 12
              serotonin receptor activity + 43
              sulfonylurea receptor activity 4
              taste receptor activity + 41
              tiggrin receptor activity 0
              transmembrane receptor protein kinase activity + 80
              transmembrane receptor protein phosphatase activity + 5
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