Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:stress-related disorder
go back to main search page
Accession:DOID:9001131 term browser browse the term
Definition:This is a mental health disorder that is the result of an atypical response to both short and long-term anxiety due to physical, mental, or emotional stress.
Synonyms:exact_synonym: stress-related disorders
 xref: EFO:0010098


show annotations for term's descendants           Sort by:
stress-related disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 sexual_dimorphism ISO RGD PMID:27894930 RGD:401959751 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 sexual_dimorphism ISO associated with prenatal exposure delayed effects; mRNA:altered expression: hippocampus (rat)
mRNA:altered expr:brain (rat)		 RGD PMID:29251811 PMID:29990678 RGD:401965484, RGD:401976282 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 sexual_dimorphism ISO RGD PMID:27894930 RGD:401959751 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Drd1 dopamine receptor D1 sexual_dimorphism ISO mRNA:decreased expression:nucleus accumbens (rat) RGD PMID:23579081 RGD:401976414 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 sexual_dimorphism ISO mRNA:decreased expression:nucleus accumbens (rat) RGD PMID:23579081 RGD:401976414 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO protein:decreased expression, decreased phosphorylation:myocardium RGD PMID:27133902 RGD:405650400 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO protein:increased phosphorylation:myocardium RGD PMID:27133902 RGD:405650400 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Gal galanin and GMAP prepropeptide IEP mRNA:increased expression:nucleus accumbens (mouse) RGD PMID:23639882 RGD:408345223 NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544 		JBrowse link
G Galr1 galanin receptor 1 IEP mRNA:increased expression:nucleus accumbens (mouse) RGD PMID:23639882 RGD:408345223 NCBI chr18:82,410,621...82,424,902
Ensembl chr18:82,410,505...82,424,902 		JBrowse link
G Galr2 galanin receptor 2 IEP mRNA:increased expression:nucleus accumbens RGD PMID:23639882 RGD:408345223 NCBI chr11:116,170,520...116,174,776
Ensembl chr11:116,171,765...116,174,764 		JBrowse link
G Gfap glial fibrillary acidic protein sexual_dimorphism ISO RGD PMID:27894930 RGD:401959751 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO RGD PMID:37794307 RGD:401901277 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 sexual_dimorphism ISO RGD PMID:27894930 RGD:401959751 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Ngf nerve growth factor ISO mRNA,protein:altered expression:hypothalamus RGD PMID:26771945 RGD:402463957 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 sexual_dimorphism
sexual_dimorphism 		ISO
IEP		 mRNA:altered expression:brain
protein:altered expression:hippocampus (rat)
mRNA:increased expression:hippocampus
DNA, mRNA, protein:hypermethylation, decreased expression:promoter, hypothalamus
mRNA:decreased expression:hippocampus		 RGD PMID:29990678 PMID:10399770 PMID:25988842 PMID:31102593 PMID:35661969 More... RGD:401976282, RGD:401976290, RGD:408345224, RGD:408345228, RGD:408364968, RGD:408364989 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 sexual_dimorphism ISO associated with prenatal exposure delayed effects; mRNA:altered expression: hippocampus (rat)
mRNA:altered expr:brain (rat)
protein:altered expression:hippocampus (rat)
associated with prenatal alcohol exposure; mRNA:increased expression:hippocampus (rat)
associated with caloric restriction, males; mRNA:increased expression:hippocampus (rat)		 RGD PMID:29251811 PMID:29990678 PMID:10399770 PMID:23579081 PMID:23579081 RGD:401965484, RGD:401976282, RGD:401976290, RGD:401976414, RGD:401976414 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Nrg1 neuregulin 1 ISO protein:increased expression:myocardium RGD PMID:23022220 PMID:27133902 RGD:39128254, RGD:405650400 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO mRNA:increased expression:dorsal striatum (rat)
associated with heroin dependence;DNA:SNP:intron (rs2236857) (human)		 RGD PMID:28511993 PMID:30171993 RGD:401976432, RGD:401977579 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO mRNA:increased expression:dorsal striatum (rat) RGD PMID:28511993 RGD:401976432 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO mRNA:increased expression:dorsal striatum (rat) RGD PMID:28511993 RGD:401976432 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO mRNA:increased expression:amygdala (rat)
associated with alcohol withdrawal syndrome;DNA:SNP: :rs2071345		 RGD PMID:28511993 PMID:35592377 RGD:401976432, RGD:407431641 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Syp synaptophysin sexual_dimorphism ISO RGD PMID:27894930 RGD:401959751 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16230
    disease of anatomical entity 15849
      nervous system disease 13769
        central nervous system disease 12288
          brain disease 11539
            disease of mental health 8315
              Trauma and Stressor Related Disorders 45
                stress-related disorder 22
paths to the root