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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Trauma and Stressor Related Disorders
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Accession:DOID:9004763 term browser browse the term
Definition:Disorders in which exposure to a traumatic or stressful event is explicitly a diagnostic criterion.
Synonyms:narrow_synonym: occupation-related stress disorder
 primary_id: MESH:D000068099
 xref: EFO:0005250



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Trauma and Stressor Related Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir222 microRNA 222 disease_progression IEP RGD PMID:22078298 RGD:152023731 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 disease_progression IEP RGD PMID:22078298 RGD:152023731 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase disease_progression IEP RGD PMID:22078298 RGD:152023731 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase IEP RGD PMID:20645790 RGD:5509849 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Crp C-reactive protein ISO RGD PMID:19628221 RGD:9585647 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
Acute Stress Disorders, Traumatic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2a 5-hydroxytryptamine receptor 2A treatment IMP RGD PMID:15507224 RGD:401900762 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
adjustment disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17988634 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor susceptibility
treatment
ISO
IEP
DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 PMID:28791385 RGD:10059367, RGD:401940159 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:32332995 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp12 caspase 12 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp9 caspase 9 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:18349090 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:27421892 RGD:405255654 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A treatment IEP RGD PMID:28791385 RGD:401940159 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21714072 RGD:5147887 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mdm2 MDM2 proto-oncogene IDA RGD PMID:23174211 RGD:10412309 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Oprm1 opioid receptor, mu 1 severity ISO DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) RGD PMID:22143634 RGD:401827931 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 treatment IMP RGD PMID:28791385 RGD:401940159 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein treatment IEP RGD PMID:17968352 RGD:8694407 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
stress-related disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IEP protein:decreased expression:serum RGD PMID:32497709 RGD:401950485 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cnr1 cannabinoid receptor 1 sexual_dimorphism IEP RGD PMID:27894930 RGD:401959751 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 sexual_dimorphism IEP associated with prenatal exposure delayed effects; mRNA:altered expression: hippocampus (rat)
mRNA:altered expr:brain (rat)
RGD PMID:29251811 PMID:29990678 RGD:401965484, RGD:401976282 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 sexual_dimorphism IEP RGD PMID:27894930 RGD:401959751 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Drd1 dopamine receptor D1 sexual_dimorphism IEP mRNA:decreased expression:nucleus accumbens (rat) RGD PMID:23579081 RGD:401976414 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 sexual_dimorphism IEP mRNA:decreased expression:nucleus accumbens (rat) RGD PMID:23579081 RGD:401976414 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Gfap glial fibrillary acidic protein sexual_dimorphism IEP RGD PMID:27894930 RGD:401959751 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IEP RGD PMID:37794307 RGD:401901277 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ncam1 neural cell adhesion molecule 1 sexual_dimorphism IEP RGD PMID:27894930 RGD:401959751 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:altered expression:hypothalamus RGD PMID:26771945 RGD:402463957 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 sexual_dimorphism IEP associated with prenatal exposure delayed effects; mRNA:altered expression: hippocampus (rat)
associated with adrenalectomy, female; mRNA:decreased expression:prefrontal cortex (rat)
mRNA:altered expr:brain (rat)
protein:altered expression:hippocampus (rat)
RGD PMID:29251811 PMID:30367959 PMID:29990678 PMID:10399770 RGD:401965484, RGD:401966864, RGD:401976282, RGD:401976290 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 sexual_dimorphism IEP associated with prenatal exposure delayed effects; mRNA:altered expression: hippocampus (rat)
mRNA:altered expr:brain (rat)
protein:altered expression:hippocampus (rat)
associated with prenatal alcohol exposure; mRNA:increased expression:hippocampus (rat)
associated with caloric restriction, males; mRNA:increased expression:hippocampus (rat)
RGD PMID:29251811 PMID:29990678 PMID:10399770 PMID:23579081 PMID:23579081 RGD:401965484, RGD:401976282, RGD:401976290, RGD:401976414, RGD:401976414 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nrg1 neuregulin 1 IMP RGD PMID:23022220 RGD:39128254 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nrg1Tn(sb-T2/Bart3)2.183Mcwi neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin IMP RGD PMID:23022220 RGD:39128254
G Oprd1 opioid receptor, delta 1 IEP
ISO
mRNA:increased expression:dorsal striatum (rat)
associated with heroin dependence;DNA:SNP:intron (rs2236857) (human)
RGD PMID:28511993 PMID:30171993 RGD:401976432, RGD:401977579 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 IEP mRNA:increased expression:dorsal striatum (rat) RGD PMID:28511993 RGD:401976432 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 IEP mRNA:increased expression:dorsal striatum (rat) RGD PMID:28511993 RGD:401976432 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pomc proopiomelanocortin IEP mRNA:increased expression:amygdala (rat) RGD PMID:28511993 RGD:401976432 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Syp synaptophysin sexual_dimorphism IEP RGD PMID:27894930 RGD:401959751 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          brain disease 11633
            disease of mental health 8300
              Trauma and Stressor Related Disorders 45
                acute stress disorder + 26
                adjustment disorder 1
                stress-related disorder 20
paths to the root