Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bronchial Hyperreactivity
go back to main search page
Accession:DOID:9000772 term browser browse the term
Definition:Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Synonyms:exact_synonym: Bronchial Hyperreactivities
 primary_id: MESH:D016535

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
Bronchial Hyperreactivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17061022 NCBI chrNW_004624741:4,764,508...4,778,174
Ensembl chrNW_004624741:4,766,306...4,775,501 		JBrowse link
G Calca calcitonin related polypeptide alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15127121 PMID:16777450 NCBI chrNW_004624766:6,764,388...6,771,396
Ensembl chrNW_004624766:6,766,185...6,768,173 		JBrowse link
G Cd14 CD14 molecule ISO associated with asthma; DNA:polymorphism:promoter:c. -159C>T (human) RGD PMID:17196641 RGD:4144784 NCBI chrNW_004624743:33,372,023...33,374,438
Ensembl chrNW_004624743:33,367,898...33,373,922 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO DNA:polymorphism:exon:49A>G (human) RGD PMID:12114354 RGD:4891522 NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO associated with Respiratory Syncytial Virus Infections RGD PMID:16238585 RGD:4846883 NCBI chrNW_004624836:2,556,269...2,597,008 JBrowse link
G Dpp10 dipeptidyl peptidase like 10 ISO RGD PMID:19951440 RGD:4892274 NCBI chrNW_004624732:29,385,895...30,748,424
Ensembl chrNW_004624732:29,386,401...30,042,127 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:16522460 RGD:4892312 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Gata3 GATA binding protein 3 ISO RGD PMID:20118299 RGD:5128801 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G Hnmt histamine N-methyltransferase no_association ISO RGD PMID:15693910 RGD:5128888 NCBI chrNW_004624732:37,621,014...37,689,873
Ensembl chrNW_004624732:37,620,925...37,691,708 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17014439 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Ifng interferon gamma ISO mRNA:increased expression:lung: RGD PMID:8690457 RGD:10755761 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il10 interleukin 10 ISO RGD PMID:20406594 RGD:4140467 NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732 		JBrowse link
G Il13 interleukin 13 susceptibility ISO associated with Eosinophilic enteropathy
DNA:SNP:promoter:-1055C>T (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11588017 PMID:12654629 PMID:12669034 PMID:15236177 PMID:23434795 RGD:4145432 RGD:4761594 RGD:4765128 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:18394133 RGD:4943853 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:sputum RGD PMID:12814161 PMID:20413629 RGD:4888526 RGD:4889115 NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:11766995 RGD:4889856 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein ISO DNA:SNP: :rs1420106 (human) RGD PMID:18774397 RGD:5024946 NCBI chrNW_004624749:6,930,025...6,957,241 JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:lung RGD PMID:14754758 RGD:4143217 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32777237 NCBI chrNW_004624749:6,795,822...6,873,068
Ensembl chrNW_004624749:6,795,748...6,873,701 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:14754758 RGD:4143217 NCBI chrNW_004624749:13,210,365...13,224,471
Ensembl chrNW_004624749:13,210,476...13,225,890 		JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:17920666 RGD:6892942 NCBI chrNW_004624782:12,037,338...12,070,479
Ensembl chrNW_004624782:12,057,651...12,068,650 		JBrowse link
G Il4r interleukin 4 receptor ISO RGD PMID:16890766 RGD:4890011 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Il5 interleukin 5 treatment ISO RGD PMID:9712797 PMID:10471622 RGD:11354935 RGD:4890961 NCBI chrNW_004624733:39,544,487...39,558,943
Ensembl chrNW_004624733:39,556,797...39,559,119 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO DNA:SNPs: : RGD PMID:15817799 RGD:5037231 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
G Mif macrophage migration inhibitory factor ISO RGD PMID:17373669 RGD:4891035 NCBI chrNW_004624747:10,307,826...10,308,649
Ensembl chrNW_004624747:10,303,919...10,308,821 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:19940022 RGD:5129522 NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 susceptibility ISO DNA:polymorphism:CDS: E237G (human) RGD PMID:17430357 RGD:5131116 NCBI chrNW_004624864:804,950...813,419
Ensembl chrNW_004624864:807,253...813,381 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22871964 NCBI chrNW_004624772:11,009,765...11,070,050
Ensembl chrNW_004624772:11,010,845...11,070,017 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO protein:increased expression:lung RGD PMID:19286931 RGD:5132864 NCBI chrNW_004624747:15,940,614...16,118,051
Ensembl chrNW_004624747:16,003,969...16,113,165 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Reperfusion Injury
associated with reperfusion injury; mRNA:increased expression:lung
protein:increased expression:lung, respiratory tract		 RGD PMID:11076311 PMID:17607157 PMID:19286931 PMID:20430162 RGD:4891490 RGD:4891947 RGD:4892083 RGD:5132864 NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:decreased expression:lung RGD PMID:16714207 PMID:19286931 RGD:4892061 RGD:5132864 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17508966 NCBI chrNW_004624760:12,917,244...12,937,858
Ensembl chrNW_004624760:12,915,206...12,937,824 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO RGD PMID:11597923 RGD:5144210 NCBI chrNW_004624926:1,029,120...1,030,250 JBrowse link
G Selp selectin P ISO atopy and bronchial hyperresponsiveness, OMIM:147050 DNA:point_mutation:CDS:amino acid Val640Leu RGD PMID:12929084 RGD:1599904 NCBI chrNW_004624826:7,510,039...7,544,332
Ensembl chrNW_004624826:7,511,646...7,537,924 		JBrowse link
G Sftpb surfactant protein B ISO protein:decreased expression:lung RGD PMID:14748931 RGD:4143407 NCBI chrNW_004624749:17,486,483...17,495,822
Ensembl chrNW_004624749:17,486,518...17,493,846 		JBrowse link
G Sftpc surfactant protein C ISO protein:decreased expression:lung RGD PMID:14748931 RGD:4143407 NCBI chrNW_004624758:17,742,439...17,744,664
Ensembl chrNW_004624758:17,742,415...17,744,655 		JBrowse link
G Sftpd surfactant protein D ISO protein:increased expression:lung RGD PMID:12882759 PMID:14748931 RGD:4143407 RGD:4144051 NCBI chrNW_004624841:6,917,067...6,938,594
Ensembl chrNW_004624841:6,916,849...6,936,077 		JBrowse link
G Tac1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16777450 NCBI chrNW_004624813:4,542,226...4,550,378
Ensembl chrNW_004624813:4,542,011...4,550,486 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:15272104 PMID:18063836 RGD:5147833 RGD:5147834 NCBI chrNW_004624749:28,243,667...28,455,012
Ensembl chrNW_004624749:28,243,640...28,455,086 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:20007931 RGD:4144229 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tnf tumor necrosis factor ISO associated with asthma; DNA:polymorphism:promoter: c. -308A>G (human) RGD PMID:17196641 RGD:4144784 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Trpa1 transient receptor potential cation channel subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19458046 NCBI chrNW_004624744:18,997,273...19,042,838
Ensembl chrNW_004624744:18,997,462...19,042,227 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15127121 PMID:15144609 NCBI chrNW_004624785:5,466,429...5,487,763
Ensembl chrNW_004624785:5,468,563...5,488,143 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      respiratory system disease 4527
        lower respiratory tract disease 2031
          bronchial disease 896
            Bronchial Hyperreactivity 43
paths to the root