RGD Reference Report - No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. - Rat Genome Database

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No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.

Authors: Deindl, P  Peri-Jerkan, S  Deichmann, K  Niggemann, B  Lau, S  Sommerfeld, C  Sengler, C  Muller, S  Wahn, U  Nickel, R  Heinzmann, A  Heinzmann, Andrea 
Citation: Deindl P, etal., Pediatr Allergy Immunol. 2005 Feb;16(1):40-2.
RGD ID: 5128888
Pubmed: PMID:15693910   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1399-3038.2005.00218.x   (Journal Full-text)

Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma no_associationIAGP 5128888 RGD 
asthma no_associationISOHNMT (Homo sapiens)5128888; 5128888 RGD 
Bronchial Hyperreactivity no_associationIAGP 5128888 RGD 
Bronchial Hyperreactivity no_associationISOHNMT (Homo sapiens)5128888; 5128888 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hnmt  (histamine N-methyltransferase)

Genes (Mus musculus)
Hnmt  (histamine N-methyltransferase)

Genes (Homo sapiens)
HNMT  (histamine N-methyltransferase)


Additional Information