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ONTOLOGY REPORT - ANNOTATIONS


Term:safrole
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Accession:CHEBI:8994 term browser browse the term
Definition:A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Synonyms:exact_synonym: 5-allyl-1,3-benzodioxole
 related_synonym: 1,2-methylenedioxy-4-allylbenzene;   1-allyl-3,4-methylenedioxybenzene;   3,4-(methylenedioxy)allylbenzene;   3-(3,4-methylenedioxyphenyl)prop-1-ene;   4-allyl-1,2-methylenedioxybenzene;   4-allylpyrocatechol formaldehyde acetal;   5-(2-propenyl)-1,3-benzodioxole;   5-allyl-benzo[1,3]dioxole;   Formula=C10H10O2;   InChI=1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2,4-6H,1,3,7H2;   InChIKey=ZMQAAUBTXCXRIC-UHFFFAOYSA-N;   SMILES=C=CCc1ccc2OCOc2c1;   allylcatechol methylene ether;   m-allylpyrocatechin methylene ether;   safrol;   shikimol;   shikimole
 xref: CAS:94-59-7 "ChemIDplus";   CAS:94-59-7 "KEGG COMPOUND";   CAS:94-59-7 "NIST Chemistry WebBook";   HMDB:HMDB0033591;   KEGG:C10490;   KNApSAcK:C00002771
 xref_mesh: MESH:D012451
 xref: PMID:14422 "Europe PMC";   PMID:15334724 "Europe PMC";   PMID:19656034 "Europe PMC";   PMID:21089955 "Europe PMC";   PMID:21173435 "Europe PMC";   PMID:21591240 "Europe PMC";   PMID:21863093 "Europe PMC";   PMID:23112005 "Europe PMC";   PMID:24150866 "Europe PMC";   PMID:6191767 "Europe PMC";   PMID:7030889 "Europe PMC";   PMID:7806308 "Europe PMC";   Reaxys:136380 "Reaxys";   Wikipedia:Safrole


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safrole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pesticide 15800
          insecticide 12496
            safrole 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      benzodioxoles 7643
                                        safrole 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.