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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:8994
Term: safrole
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.
Chemical ID: MESH:D012451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases activityISOCYP2D6 (Homo sapiens)6480464CTDSafrole results in decreased activity of CYP2D6 proteinPMID:15778010
Cyp2d4increases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased metabolism of SafrolePMID:20507880
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrolePMID:20507880
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