CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tauroursodeoxycholic acid
Accession: CHEBI:80774
browse the term
Definition: A bile acid taurine conjugate derived from ursoodeoxycholic acid.
Synonyms: exact_synonym: 2-[(3alpha,7beta-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
related_synonym: 2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonic acid; 2-{[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethane-1-sulfonic acid; 3alpha,7beta-dihydroxy-5beta-cholanoyltaurine; Formula=C26H45NO6S; InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1; InChIKey=BHTRKEVKTKCXOH-LBSADWJPSA-N; N-(3-alpha,7-beta-Dihydroxy-5-beta-cholan-24-oyl)-Taurine; N-(3alpha,7beta-dihydroxy-5beta-cholan-24-oyl)taurine; N-ursodeoxycholoyltaurine; SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@H](C[C@@]2(C[C@@H](C1)O)[H])O)[H])(CC[C@]4([H])[C@@H](CCC(NCCS(O)(=O)=O)=O)C)[H])C)[H])C; TUDCA; Taurolite; UR 906; Ursodeoxycholyltaurine
alt_id: CHEBI:132326
xref: CAS:14605-22-2; HMDB:HMDB0000874; KEGG:C16868; LIPID_MAPS_instance:LMST05040015
xref_mesh: MESH:C031655
xref: MetaCyc:CPD-18799; PDBeChem:5D5; PMID:25664595; PMID:26282527; PMID:26427442; PMID:26499839; PMID:26541419; PMID:26748055; PMID:26759227; PMID:26765262; PMID:26907328; PMID:26922713; PMID:26988565; PMID:27106542; PMID:27124655; PMID:27154200; PMID:27219292; Reaxys:3228312; Wikipedia:Tauroursodeoxycholic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:132028
G
ATF4
activating transcription factor 4
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF4 mRNA]
CTD
PMID:37207789
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
G
ATF6
activating transcription factor 6
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF6 mRNA]
CTD
PMID:37207789
NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
G
CAT
catalase
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of CAT mRNA]
CTD
PMID:37207789
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
G
DDIT3
DNA damage inducible transcript 3
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of DDIT3 mRNA]
CTD
PMID:37207789
NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
G
HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of HSPA5 mRNA]
CTD
PMID:37207789
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
PTGS1
prostaglandin-endoperoxide synthase 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS1 mRNA]
CTD
PMID:37207789
NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
G
PTGS2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS2 mRNA]
CTD
PMID:37207789
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
PTX3
pentraxin 3
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTX3 mRNA]
CTD
PMID:37207789
NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
G
SOD1
superoxide dismutase 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of SOD1 mRNA]
CTD
PMID:37207789
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
G
SOD2
superoxide dismutase 2
multiple interactions
EXP
ursodoxicoltaurine affects the reaction [Cadmium results in increased expression of SOD2 mRNA]
CTD
PMID:37207789
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
G
TNFAIP6
TNF alpha induced protein 6
multiple interactions
EXP
[ursodoxicoltaurine co-treated with Cadmium] results in increased expression of TNFAIP6 mRNA; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of TNFAIP6 mRNA]
CTD
PMID:37207789
NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461
G
XBP1
X-box binding protein 1
multiple interactions
EXP
ursodoxicoltaurine inhibits the reaction [Cadmium results in increased splicing of XBP1 mRNA]
CTD
PMID:37207789
NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all