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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ursodeoxycholic acid
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Accession:CHEBI:9907 term browser browse the term
Definition:A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Synonyms:related_synonym: (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid;   3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid;   Actigall;   Formula=C24H40O4;   InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1;   InChIKey=RUDATBOHQWOJDD-UZVSRGJWSA-N;   SMILES=[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@@H](O)C2)[C@H](C)CCC(O)=O;   Ursodeoxycholate;   Ursodiol
 xref: Beilstein:3219888;   CAS:128-13-2;   DrugBank:DB01586;   Drug_Central:2797;   HMDB:HMDB0000946;   KEGG:C07880;   KEGG:D00734;   LINCS:LSM-6555;   LIPID_MAPS_instance:LMST04010033
 xref_mesh: MESH:D014580
 xref: PMID:14989050;   PMID:17489439;   PMID:24816727;   Reaxys:3219888;   Wikipedia:Ursodiol
 cyclic_relationship: is_conjugate_acid_of CHEBI:78604


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ursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of AADAT mRNA CTD PMID:15885361 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
decreases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCB11 mRNA; Ursodeoxycholic Acid results in increased expression of ABCB11 protein
Ursodeoxycholic Acid results in decreased expression of ABCB11 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]
CTD PMID:11438506 PMID:12187295 PMID:14684751 PMID:25055961 PMID:25418378 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCB1 mRNA
Ursodeoxycholic Acid results in increased expression of ABCB1A mRNA
CTD PMID:15885361 PMID:16678547 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCB4 mRNA CTD PMID:25582706 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
EXP
ISO
Ursodeoxycholic Acid results in increased expression of ABCC1 mRNA
Ursodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:16101123 PMID:16764892 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
increases activity
affects expression
ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCC2; Ursodeoxycholic Acid results in increased expression of ABCC2 protein
Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC2 protein
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 protein]
Ursodeoxycholic Acid results in increased activity of ABCC2 protein
ABCC2 affects the reaction [Ursodeoxycholic Acid results in increased secretion of Nitric Oxide]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased activity of ABCC2 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
Ursodeoxycholic Acid affects the expression of ABCC2 mRNA; Ursodeoxycholic Acid affects the expression of ABCC2 protein
CTD PMID:11438506 PMID:12606635 PMID:12971955 PMID:15843489 PMID:15956029 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
affects expression
ISO
EXP
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 protein]
Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC3 protein
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 protein]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC3 promoter]
Ursodeoxycholic Acid affects the expression of ABCC3 protein
CTD PMID:12971955 PMID:16472600 PMID:16764892 PMID:18687751 PMID:25055961 More... NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
affects expression
ISO
EXP
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 protein]
Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC4 protein
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC4 promoter]
Ursodeoxycholic Acid affects the expression of ABCC4 protein
CTD PMID:16472600 PMID:18687751 PMID:25582706 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCG5 mRNA CTD PMID:25582706 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCG8 mRNA CTD PMID:25582706 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ACTN1 mRNA CTD PMID:15885361 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
increases secretion
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of AHR mRNA
AHR gene mutant form results in increased secretion of Ursodeoxycholic Acid
AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Ursodeoxycholic Acid]
CTD PMID:18687751 PMID:29452137 PMID:32679164 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Ursodeoxycholic Acid results in increased expression of AKR1B8 mRNA CTD PMID:15885361 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity
ISO Ursodeoxycholic Acid inhibits the reaction [[AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone]
Ursodeoxycholic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8573067 PMID:12604236 PMID:23261716 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Ursodeoxycholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:19073151 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ankrd28 ankyrin repeat domain 28 affects expression ISO Ursodeoxycholic Acid affects the expression of ANKRD28 mRNA CTD PMID:18422935 NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 affects expression ISO Ursodeoxycholic Acid affects the expression of AP2M1 mRNA CTD PMID:18422935 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of APAF1 mRNA; Ursodeoxycholic Acid results in decreased expression of APAF1 protein CTD PMID:15885361 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Ursodeoxycholic Acid results in increased expression of APOA1 mRNA CTD PMID:15115973 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apom apolipoprotein M multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein] CTD PMID:22160096 NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of AQP8 mRNA CTD PMID:15885361 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Arg1 arginase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ARG1 mRNA CTD PMID:15885361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of ARL1 mRNA CTD PMID:15885361 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein] CTD PMID:14761680 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of ATF4 mRNA CTD PMID:24312631 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of ATP8B1 mRNA CTD PMID:25582706 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
Ursodeoxycholic Acid results in increased expression of BAX
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased expression of and affects the localization of BAX protein]
Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
Ursodeoxycholic Acid results in decreased expression of BAX protein
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Okadaic Acid results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of and results in increased localization of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX protein]
CTD PMID:9562975 PMID:10510466 PMID:14514686 PMID:15970352 PMID:17461466 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 protein]
Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
Ursodeoxycholic Acid results in decreased expression of BCL2 protein
CTD PMID:14514686 PMID:15970352 PMID:17461466 PMID:21419764 PMID:25502462 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bet1 Bet1 golgi vesicular membrane trafficking protein increases expression EXP Ursodeoxycholic Acid results in increased expression of BET1 mRNA CTD PMID:15885361 NCBI chr 4:32,116,232...32,126,592
Ensembl chr 4:32,116,235...32,126,617
JBrowse link
G Blvra biliverdin reductase A increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of BLVRA mRNA
Ursodeoxycholic Acid results in increased expression of BLVRA mRNA; Ursodeoxycholic Acid results in increased expression of BLVRA protein
CTD PMID:18706437 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
JBrowse link
G C4bpa complement component 4 binding protein, alpha affects expression ISO Ursodeoxycholic Acid affects the expression of C4BPA mRNA CTD PMID:18422935 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G Capn2 calpain 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CAPN2 mRNA CTD PMID:15885361 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [CAR2 results in increased expression of IL2 mRNA] CTD PMID:15816485 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO
EXP
[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; TP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]; Ursodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP3 protein]; Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP3 protein
Ursodeoxycholic Acid results in decreased activity of CASP3 protein
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
CTD PMID:14514686 PMID:15222754 PMID:15970352 PMID:16310035 PMID:16432164 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:21362627 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP7 protein]
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP7 protein]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein]
CTD PMID:21146893 PMID:22178905 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO
EXP
[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; TP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; Ursodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP8 protein]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein]
CTD PMID:16432164 PMID:19728331 PMID:21146893 PMID:21362627 PMID:25502462 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP9 protein]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP9 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP9 protein]
CTD PMID:22178905 PMID:25502462 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL2 mRNA]]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]
Ursodeoxycholic Acid results in increased expression of CCL2 mRNA
CTD PMID:21146893 PMID:24312631 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL5 mRNA]]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CCL5 mRNA]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein]
CTD PMID:21146893 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CCN2 mRNA CTD PMID:15885361 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in decreased expression of CCND1 protein
Ursodeoxycholic Acid results in decreased expression of CCND1 mRNA; Ursodeoxycholic Acid results in decreased expression of CCND1 protein
Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein]
CTD PMID:12496057 PMID:15885361 PMID:17431217 PMID:17461466 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of CCND3 protein CTD PMID:17461466 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 affects expression ISO Ursodeoxycholic Acid affects the expression of CCT3 mRNA CTD PMID:18422935 NCBI chr 2:173,765,792...173,790,353
Ensembl chr 2:173,765,698...173,790,757
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 affects expression ISO Ursodeoxycholic Acid affects the expression of CCT5 mRNA CTD PMID:18422935 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Cd14 CD14 molecule increases expression EXP Ursodeoxycholic Acid results in increased expression of CD14 mRNA CTD PMID:15885361 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd248 CD248 molecule affects expression ISO Ursodeoxycholic Acid affects the expression of CD248 mRNA CTD PMID:18422935 NCBI chr 1:202,373,676...202,376,240
Ensembl chr 1:202,373,676...202,376,240
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]
Ursodeoxycholic Acid results in decreased expression of CDH1 mRNA
CTD PMID:12496057 PMID:15885361 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh17 cadherin 17 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CDH17 mRNA CTD PMID:15885361 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CEBPB] CTD PMID:18444174 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Ursodeoxycholic Acid results in increased expression of CEBPD mRNA CTD PMID:15885361 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO Ursodeoxycholic Acid analog results in increased expression of CFLAR protein CTD PMID:21146893 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CITED2 mRNA CTD PMID:15885361 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase affects expression ISO Ursodeoxycholic Acid affects the expression of CNP mRNA CTD PMID:18422935 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Ursodeoxycholic Acid results in decreased expression of COL3A1 mRNA CTD PMID:18479249 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Crebbp CREB binding protein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CREBBP mRNA CTD PMID:19493473 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CRYAB mRNA CTD PMID:15885361 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cse1l chromosome segregation 1 like affects expression ISO Ursodeoxycholic Acid affects the expression of CSE1L mRNA CTD PMID:18422935 NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 affects expression ISO Ursodeoxycholic Acid affects the expression of CSPG4 mRNA CTD PMID:18422935 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of CXCL1 mRNA CTD PMID:24312631 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Ursodeoxycholic Acid results in increased expression of CXCL10 mRNA CTD PMID:15885361 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
decreases secretion
ISO Ursodeoxycholic Acid results in decreased expression of CXCL2 mRNA; Ursodeoxycholic Acid results in decreased expression of CXCL2 protein
Ursodeoxycholic Acid results in decreased secretion of CXCL2 protein
CTD PMID:17888421 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Ursodeoxycholic Acid results in increased expression of CXCL1 mRNA CTD PMID:24312631 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA] CTD PMID:10706104 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of CYP26A1 mRNA CTD PMID:15885361 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of CYP27A1 mRNA
Ursodeoxycholic Acid results in decreased expression of CYP27A1 mRNA
CTD PMID:16764892 PMID:25582706 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
affects expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2B1 protein]
Ursodeoxycholic Acid affects the expression of CYP2B10 protein
CTD PMID:10453939 PMID:16472600 PMID:32198087 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2B3 mRNA CTD PMID:15885361 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP2C11 protein] CTD PMID:10453939 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2C12 mRNA CTD PMID:15885361 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP2C6V1 protein] CTD PMID:10453939 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2C7 mRNA CTD PMID:15885361 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2E1 protein] CTD PMID:10453939 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP3A2 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP3A2 mRNA]
CYP3A4 protein affects the metabolism of Ursodeoxycholic Acid
Ursodeoxycholic Acid results in increased expression of CYP3A4 mRNA
[CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid
Ursodeoxycholic Acid results in increased expression of CYP3A2 mRNA
CTD PMID:10453939 PMID:15708356 PMID:16678547 PMID:19255942 PMID:19487251 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19255942 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP4A1 protein] CTD PMID:10453939 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Tretinoin co-treated with Ursodeoxycholic Acid] results in decreased expression of CYP7A1 mRNA; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]
Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA
Ursodeoxycholic Acid results in increased expression of CYP7A1 mRNA
Tretinoin promotes the reaction [Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]; Ursodeoxycholic Acid promotes the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]
CTD PMID:14684751 PMID:16487557 PMID:16764892 PMID:20671298 PMID:21274875 More... NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:20671298 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of CYP8B1 mRNA
Ursodeoxycholic Acid results in decreased expression of CYP8B1 mRNA
CTD PMID:16764892 PMID:25582706 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dap3 death associated protein 3 affects expression ISO Ursodeoxycholic Acid affects the expression of DAP3 mRNA CTD PMID:18422935 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Ursodeoxycholic Acid results in increased expression of DDIT3 mRNA CTD PMID:15885361 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhx9 DExH-box helicase 9 affects expression ISO Ursodeoxycholic Acid affects the expression of DHX9 mRNA CTD PMID:18422935 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase affects expression ISO Ursodeoxycholic Acid affects the expression of DLAT mRNA CTD PMID:18422935 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions
increases expression
ISO DLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein]
Ursodeoxycholic Acid results in increased expression of DLC1 protein
CTD PMID:21455586 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dmgdh dimethylglycine dehydrogenase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DMGDH mRNA CTD PMID:15885361 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of DNAJC3 mRNA
Ursodeoxycholic Acid results in decreased expression of DNAJC3 mRNA
CTD PMID:15885361 PMID:24312631 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dnase2b deoxyribonuclease 2 beta decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DNASE2B mRNA CTD PMID:15885361 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DPP4 mRNA CTD PMID:15885361 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
decreases expression
EXP NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein] CTD PMID:14514686 PMID:15222754 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ECI1 mRNA CTD PMID:15885361 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of EDN1 mRNA; Ursodeoxycholic Acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of EDN2 protein CTD PMID:15691296 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of EGFR protein] CTD PMID:14747693 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of EGLN3 mRNA CTD PMID:15885361 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Ursodeoxycholic Acid affects the expression of EIF1 mRNA CTD PMID:18422935 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; Ursodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter] CTD PMID:18188457 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 affects expression ISO Ursodeoxycholic Acid affects the expression of ERMP1 mRNA CTD PMID:18422935 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of FABP4 mRNA CTD PMID:24312631 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fabp6 fatty acid binding protein 6 multiple interactions
increases expression
ISO Ursodeoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased expression of FABP6 mRNA]
Ursodeoxycholic Acid results in increased expression of FABP6 mRNA
CTD PMID:15935148 PMID:25582706 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of FADS1 mRNA CTD PMID:15885361 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads3 fatty acid desaturase 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of FADS3 mRNA CTD PMID:15885361 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
JBrowse link
G Fam169a family with sequence similarity 169, member A affects expression ISO Ursodeoxycholic Acid affects the expression of FAM169A mRNA CTD PMID:18422935 NCBI chr 2:28,384,162...28,441,361
Ensembl chr 2:28,383,784...28,438,910
JBrowse link
G Fasn fatty acid synthase decreases expression EXP
ISO
Ursodeoxycholic Acid results in decreased expression of FASN mRNA CTD PMID:15885361 PMID:24312631 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions
increases expression
ISO Ursodeoxycholic Acid promotes the reaction [Tretinoin results in increased expression of FGF19 mRNA]
Ursodeoxycholic Acid results in increased expression of FGF15 mRNA
Ursodeoxycholic Acid results in increased expression of FGF19 mRNA
CTD PMID:21274875 PMID:25055961 PMID:25582706 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO Ursodeoxycholic Acid affects the expression of FGG mRNA CTD PMID:18422935 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fgl1 fibrinogen-like 1 affects expression ISO Ursodeoxycholic Acid affects the expression of FGL1 mRNA CTD PMID:18422935 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GAMT mRNA CTD PMID:15885361 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gars glycyl-tRNA synthetase affects expression ISO Ursodeoxycholic Acid affects the expression of GARS1 mRNA CTD PMID:18422935 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gckr glucokinase regulator decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GCKR mRNA CTD PMID:15885361 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]
Ursodeoxycholic Acid results in increased expression of GCLC mRNA; Ursodeoxycholic Acid results in increased expression of GCLC protein
CTD PMID:18687751 PMID:19073151 PMID:20146260 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA] CTD PMID:19073151 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of GPBAR1 mRNA CTD PMID:24312631 NCBI chr 9:75,862,151...75,863,140
Ensembl chr 9:75,860,677...75,863,168
JBrowse link
G Gpnmb glycoprotein nmb decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GPNMB mRNA CTD PMID:15885361 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in increased activity of GPT protein] CTD PMID:15950962 PMID:27743861 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grb14 growth factor receptor bound protein 14 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GRB14 mRNA CTD PMID:15885361 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Gss glutathione synthetase multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA] CTD PMID:19073151 PMID:20146260 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Ursodeoxycholic Acid results in increased expression of GSTA2 mRNA CTD PMID:18687751 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GSTA5 mRNA CTD PMID:15885361 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Ursodeoxycholic Acid results in increased expression of GSTA2 mRNA CTD PMID:18687751 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GSTM3 mRNA CTD PMID:15885361 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HAAO mRNA CTD PMID:15885361 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of HBP1 mRNA CTD PMID:15885361 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HDHD2 mRNA CTD PMID:15885361 NCBI chr18:70,475,037...70,526,471
Ensembl chr18:70,474,926...70,526,470
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF mRNA]; Ursodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]; Ursodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF mRNA]; Ursodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]
Ursodeoxycholic Acid results in increased expression of HGF mRNA
CTD PMID:11983124 PMID:15802798 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity EXP Ursodeoxycholic Acid results in decreased activity of HMGCR protein CTD PMID:6832710 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HMGCS2 mRNA CTD PMID:15885361 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]; Ursodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter] CTD PMID:18188457 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hnf1b HNF1 homeobox B multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form] CTD PMID:18188457 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
JBrowse link
G Hpn hepsin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HPN mRNA CTD PMID:15885361 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of HRAS protein] CTD PMID:12839936 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HRG mRNA CTD PMID:15885361 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases abundance
ISO [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid
HSD11B1 gene mutant form results in increased abundance of Ursodeoxycholic Acid
CTD PMID:21453287 PMID:25061560 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HSD17B6 mRNA CTD PMID:15885361 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24312631 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IFNG protein]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:8568266 PMID:12620498 PMID:32198087 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP Ursodeoxycholic Acid results in decreased expression of IGFALS mRNA CTD PMID:15885361 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of IGFBP1 mRNA CTD PMID:15885361 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases abundance
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of IL10 protein]
IL10 gene mutant form results in decreased abundance of Ursodeoxycholic Acid
CTD PMID:25502462 PMID:27580383 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP Tretinoin inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of IL1B mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of IL1B protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of IL1B mRNA] CTD PMID:21274875 PMID:25502462 PMID:32198087 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [CAR2 results in increased expression of IL2 mRNA] CTD PMID:15816485 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of IL6 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased secretion of IL6 protein]]
Ursodeoxycholic Acid results in decreased secretion of IL6 protein
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
CTD PMID:17888421 PMID:18590720 PMID:21146893 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 affects expression ISO Ursodeoxycholic Acid affects the expression of IMPDH2 mRNA CTD PMID:18422935 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
JBrowse link
G Irs2 insulin receptor substrate 2 increases expression EXP Ursodeoxycholic Acid results in increased expression of IRS2 mRNA CTD PMID:15885361 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Ivl involucrin decreases expression ISO Ursodeoxycholic Acid results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Klf15 Kruppel-like factor 15 increases expression EXP Ursodeoxycholic Acid results in increased expression of KLF15 mRNA CTD PMID:15885361 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased mutagenesis of KRAS gene] CTD PMID:12839936 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt18 keratin 18 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of KRT18 mRNA CTD PMID:15885361 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt19 keratin 19 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of KRT19 mRNA] CTD PMID:21274875 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Lgals5 galectin 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of LGALS5 mRNA CTD PMID:15885361 NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of LMAN1 mRNA CTD PMID:15885361 NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
JBrowse link
G Lox lysyl oxidase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of LOX mRNA CTD PMID:15885361 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein] CTD PMID:20146260 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Mafg MAF bZIP transcription factor G multiple interactions ISO S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein] CTD PMID:20146260 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MAGI3 mRNA CTD PMID:15885361 NCBI chr 2:191,514,726...191,717,048
Ensembl chr 2:191,518,506...191,716,735
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MAOB mRNA CTD PMID:15885361 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:14747693 PMID:24312631 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:14747693 PMID:24312631 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mbp myelin basic protein affects expression ISO Ursodeoxycholic Acid affects the expression of MBP mRNA CTD PMID:18422935 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ursodeoxycholic Acid analog results in increased expression of MCL1 protein CTD PMID:21146893 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
EXP
ISO
[Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]; Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]
Ursodeoxycholic Acid results in increased expression of MDM2 mRNA
MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein]
CTD PMID:14514686 PMID:15222754 PMID:15885361 PMID:17881359 PMID:20807506 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression EXP Ursodeoxycholic Acid results in increased expression of MET mRNA CTD PMID:11983124 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MGLL mRNA CTD PMID:15885361 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir21 microRNA 21 increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of MIR21 mRNA CTD PMID:20689055 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of MMP2 mRNA] CTD PMID:21274875 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mpo myeloperoxidase decreases activity ISO Ursodeoxycholic Acid results in decreased activity of MPO protein CTD PMID:17888421 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msn moesin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MSN mRNA CTD PMID:15885361 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mt2A metallothionein 2A increases expression EXP Ursodeoxycholic Acid results in increased expression of MT2A mRNA CTD PMID:10491327 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Myh9 myosin, heavy chain 9 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MYH9 mRNA CTD PMID:15885361 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects expression ISO Ursodeoxycholic Acid affects the expression of NAP1L1 mRNA CTD PMID:18422935 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases localization
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased localization of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]
Ursodeoxycholic Acid results in increased expression of NFE2L2 mRNA
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC3 promoter]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC4 promoter]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Ursodeoxycholic Acid results in increased activity of and results in increased localization of NFE2L2 protein
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA]
CTD PMID:18687751 PMID:19073151 PMID:20146260 PMID:25582706 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of NFKB1 mRNA]]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]
CTD PMID:21146893 PMID:25502462 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO Ursodeoxycholic Acid results in decreased degradation of NFKBIA protein CTD PMID:15473667 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of NOS2 protein]
Ursodeoxycholic Acid results in increased expression of NOS2
Ursodeoxycholic Acid results in decreased expression of NOS2 protein
Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NOS2 mRNA]
CTD PMID:12496057 PMID:12620498 PMID:17438113 PMID:18479249 PMID:18590720 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to NQO1 promoter]
Ursodeoxycholic Acid results in increased expression of NQO1 mRNA; Ursodeoxycholic Acid results in increased expression of NQO1 protein
CTD PMID:18687751 PMID:25582706 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP
ISO
Ursodeoxycholic Acid results in increased expression of NR0B2 mRNA CTD PMID:16764892 PMID:18706437 PMID:21274875 PMID:25055961 PMID:25582706 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
multiple interactions
increases expression
decreases expression
affects binding
ISO
EXP
Ursodeoxycholic Acid results in increased activity of NR1H4 protein
ursodeoxycholic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; ursodeoxycholic acid increases expression of nr1h4 mRNA and protein in rat embryonic liver cells
Chenodeoxycholic Acid inhibits the reaction [Ursodeoxycholic Acid binds to NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Ursodeoxycholic Acid results in increased expression of NR1H4 mRNA
Ursodeoxycholic Acid results in decreased expression of NR1H4 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in increased expression of NR1H4 mRNA]
Ursodeoxycholic Acid results in increased expression of NR1H4 mRNA; Ursodeoxycholic Acid results in increased expression of NR1H4 protein
CTD PMID:14684751 PMID:15935148 PMID:17567710 PMID:18706437 PMID:21274875 More... RGD:15042872 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA]
CTD PMID:18687751 PMID:18706437 PMID:25582706 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases localization
affects localization
increases expression
increases activity
EXP
ISO
[Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 protein]; Ursodeoxycholic Acid results in increased expression of and results in increased localization of NR3C1 protein
Ursodeoxycholic Acid results in increased localization of NR3C1 protein
[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased localization of NR3C1 protein; [Ursodeoxycholic Acid co-treated with NR3C1] results in decreased expression of HLA-DRA mRNA
Ursodeoxycholic Acid affects the localization of NR3C1 protein
Ursodeoxycholic Acid results in increased expression of NR3C1 mRNA
Ursodeoxycholic Acid results in increased activity of NR3C1 protein
CTD PMID:8568266 PMID:15222754 PMID:15674094 PMID:16175607 PMID:18188457 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases expression
increases localization
EXP [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]
Ursodeoxycholic Acid results in increased expression of NR3C2 mRNA
Ursodeoxycholic Acid results in increased localization of NR3C2 protein
CTD PMID:15222754 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA]
CTD PMID:18687751 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Nucb2 nucleobindin 2 increases expression EXP Ursodeoxycholic Acid results in increased expression of NUCB2 mRNA CTD PMID:15885361 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Ursodeoxycholic Acid results in increased expression of NUPR1 mRNA CTD PMID:15885361 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oaf out at first homolog affects expression ISO Ursodeoxycholic Acid affects the expression of OAF mRNA CTD PMID:18422935 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Oplah 5-oxoprolinase (ATP-hydrolysing) decreases expression EXP Ursodeoxycholic Acid results in decreased expression of OPLAH mRNA CTD PMID:15885361 NCBI chr 7:108,011,472...108,051,751
Ensembl chr 7:108,011,475...108,035,297
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of OTC mRNA CTD PMID:15885361 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:19728331 PMID:21362627 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein] CTD PMID:17438113 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Perp p53 apoptosis effector related to PMP22 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PERP mRNA CTD PMID:15885361 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pgr progesterone receptor multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein] CTD PMID:14728856 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PKLR mRNA CTD PMID:15885361 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of PLA2G2A protein]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A mRNA]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A protein] CTD PMID:10025872 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Ursodeoxycholic Acid results in decreased expression of PPARG mRNA CTD PMID:24312631 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of PRDX1 mRNA; Ursodeoxycholic Acid results in increased expression of PRDX1 protein CTD PMID:18687751 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkcb protein kinase C, beta increases activity ISO Ursodeoxycholic Acid results in increased activity of PRKCB protein CTD PMID:7705931 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases localization
increases response to substance
ISO Acetylcysteine inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; Butylated Hydroxyanisole inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; diphenyleneiodonium inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]
PRKCD results in increased susceptibility to Ursodeoxycholic Acid
CTD PMID:21362627 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prnp prion protein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PRNP mRNA CTD PMID:15885361 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of PTGS2]
Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PTGS2 protein]
CTD PMID:12496057 PMID:12839936 PMID:18444174 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptma prothymosin alpha increases expression EXP Ursodeoxycholic Acid results in increased expression of PTMA mRNA CTD PMID:15885361 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Rab6a RAB6A, member RAS oncogene family increases expression EXP Ursodeoxycholic Acid results in increased expression of RAB6A mRNA CTD PMID:15885361 NCBI chr 1:154,957,870...155,008,922
Ensembl chr 1:154,958,189...154,996,715
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects expression
ISO RAC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased expression of TNFRSF10B]
Ursodeoxycholic Acid affects the expression of RAC1 mRNA
CTD PMID:18422935 PMID:21362627 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:14747693 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of RB1 protein modified form CTD PMID:17461466 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase affects expression ISO Ursodeoxycholic Acid affects the expression of RBBP6 mRNA CTD PMID:18422935 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase affects expression ISO Ursodeoxycholic Acid affects the expression of RFFL mRNA CTD PMID:18422935 NCBI chr10:67,740,711...67,803,694
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Ursodeoxycholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases activity
ISO DLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein] CTD PMID:21455586 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 affects expression ISO Ursodeoxycholic Acid affects the expression of RHOBTB3 mRNA CTD PMID:18422935 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Rnf138 ring finger protein 138 increases expression EXP Ursodeoxycholic Acid results in increased expression of RNF138 mRNA CTD PMID:15885361 NCBI chr18:12,291,557...12,315,931 JBrowse link
G Rnf181 ring finger protein 181 increases expression EXP Ursodeoxycholic Acid results in increased expression of RNF181 mRNA CTD PMID:15885361 NCBI chr 4:104,414,586...104,421,433
Ensembl chr 4:104,414,605...104,421,309
JBrowse link
G Rpl10 ribosomal protein L10 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL10 mRNA CTD PMID:18422935 NCBI chr  X:152,054,547...152,056,757
Ensembl chr  X:152,054,452...152,056,761
JBrowse link
G Rpl27 ribosomal protein L27 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL27 mRNA CTD PMID:18422935 NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193
JBrowse link
G Rpl32 ribosomal protein L32 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL32 mRNA CTD PMID:18422935 NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
JBrowse link
G Rpl35a ribosomal protein L35a affects expression ISO Ursodeoxycholic Acid affects the expression of RPL35A mRNA CTD PMID:18422935
G Rpl39l ribosomal protein L39-like affects expression ISO Ursodeoxycholic Acid affects the expression of RPL39L mRNA CTD PMID:18422935 NCBI chr10:5,455,712...5,459,828
Ensembl chr10:5,454,559...5,462,029
JBrowse link
G Rpl6 ribosomal protein L6 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL6 mRNA CTD PMID:18422935 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 affects expression ISO Ursodeoxycholic Acid affects the expression of RPLP2 mRNA CTD PMID:18422935 NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645
JBrowse link
G Rps13 ribosomal protein S13 affects expression ISO Ursodeoxycholic Acid affects the expression of RPS13 mRNA CTD PMID:18422935 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
JBrowse link
G Rps27l ribosomal protein S27-like affects expression ISO Ursodeoxycholic Acid affects the expression of RPS27L mRNA CTD PMID:18422935 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
JBrowse link
G Rps28 ribosomal protein S28 affects expression ISO Ursodeoxycholic Acid affects the expression of RPS28 mRNA CTD PMID:18422935 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions
increases expression
ISO [Ursodeoxycholic Acid co-treated with NR3C1] results in decreased expression of HLA-DRA mRNA; Ursodeoxycholic Acid inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]
Ursodeoxycholic Acid results in increased expression of HLA-DRA mRNA
CTD PMID:8568266 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of S100A6 mRNA CTD PMID:15885361 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G Samd4b sterile alpha motif domain containing 4B affects expression ISO Ursodeoxycholic Acid affects the expression of SAMD4B mRNA CTD PMID:18422935 NCBI chr 1:83,689,413...83,728,652
Ensembl chr 1:83,689,413...83,713,853
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Ursodeoxycholic Acid results in decreased expression of SCD mRNA CTD PMID:24312631 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sct secretin multiple interactions
increases activity
increases response to substance
EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Go 6976 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; SLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; U 0126 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
SCT results in increased susceptibility to Ursodeoxycholic Acid; SCT results in increased susceptibility to Ursodeoxycholic Acid analog
CTD PMID:22194894 NCBI chr 1:196,382,941...196,383,635
Ensembl chr 1:196,382,856...196,383,658
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of SERP1 mRNA CTD PMID:15885361 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 affects expression ISO Ursodeoxycholic Acid affects the expression of SF3B1 mRNA CTD PMID:18422935 NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
JBrowse link
G Shld2 shieldin complex subunit 2 affects expression ISO Ursodeoxycholic Acid affects the expression of SHLD2 mRNA CTD PMID:18422935 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
increases expression
affects expression
EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]
Ursodeoxycholic Acid results in increased expression of SLC10A1 protein
Ursodeoxycholic Acid affects the expression of SLC10A1 mRNA
Ursodeoxycholic Acid results in increased expression of SLC10A1 mRNA
CTD PMID:16487557 PMID:16764892 PMID:25582706 PMID:27743861 PMID:32198087 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP
ISO
Ursodeoxycholic Acid results in increased expression of SLC10A2 mRNA CTD PMID:16764892 PMID:25582706 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC22A8 mRNA CTD PMID:15885361 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
JBrowse link
G Slc25a5 solute carrier family 25 member 5 affects expression ISO Ursodeoxycholic Acid affects the expression of SLC25A5 mRNA CTD PMID:18422935 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc26a1 solute carrier family 26 member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC26A1 mRNA CTD PMID:15885361 NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849
JBrowse link
G Slc27a5 solute carrier family 27 member 5 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [SLC27A5 protein results in increased uptake of Fatty Acids] CTD PMID:22531947 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC28A2 mRNA CTD PMID:15885361 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC2A2 mRNA CTD PMID:15885361 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions EXP
ISO
SLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased activity of SLC4A2 protein; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form; Ursodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter]; Ursodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter]
CTD PMID:18188457 PMID:22194894 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC51A mRNA CTD PMID:25055961 PMID:25582706 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC51B mRNA CTD PMID:25055961 PMID:25582706 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression
multiple interactions
increases expression
ISO
EXP
Ursodeoxycholic Acid affects the expression of SLCO1A4 mRNA
Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]
Ursodeoxycholic Acid results in increased expression of SLCO1A4 mRNA
CTD PMID:18687751 PMID:25582706 PMID:27743861 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
increases uptake
increases expression
EXP
ISO
Ursodeoxycholic Acid results in decreased expression of SLCO1B3 mRNA
Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite]
SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid; SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite
Ursodeoxycholic Acid results in increased expression of SLCO1B2 mRNA
CTD PMID:15885361 PMID:16534140 PMID:25582706 PMID:31299240 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smad3 SMAD family member 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA; Ursodeoxycholic Acid results in decreased expression of SMAD3 protein CTD PMID:19493473 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Ursodeoxycholic Acid results in increased expression of SMAD7 mRNA; Ursodeoxycholic Acid results in increased expression of SMAD7 protein CTD PMID:19493473 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of SOAT1 mRNA CTD PMID:15885361 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 affects expression ISO Ursodeoxycholic Acid affects the expression of SPRY4 mRNA CTD PMID:18422935 NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SPTBN1 mRNA CTD PMID:15885361 NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 affects expression ISO Ursodeoxycholic Acid affects the expression of SSBP1 mRNA CTD PMID:18422935 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1 CTD PMID:15918519 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stk3 serine/threonine kinase 3 affects expression ISO Ursodeoxycholic Acid affects the expression of STK3 mRNA CTD PMID:18422935 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stmn1 stathmin 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of STMN1 mRNA CTD PMID:15885361 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SULT1A1 mRNA CTD PMID:15885361 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SULT1B1 mRNA CTD PMID:15885361 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation
multiple interactions
affects expression
ISO
EXP
SULT2A1 protein results in increased sulfation of Ursodeoxycholic Acid
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 protein]
Ursodeoxycholic Acid affects the expression of SULT2A1 protein
CTD PMID:16472600 PMID:20102295 PMID:32198087 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tagln transgelin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TAGLN mRNA CTD PMID:15885361 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased expression of TAT mRNA] CTD PMID:9398635 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tbxa2r thromboxane A2 receptor decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TBXA2R protein CTD PMID:18479249 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tbxas1 thromboxane A synthase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TBXAS1 protein CTD PMID:18479249 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of TGFB1 mRNA]
Ursodeoxycholic Acid results in decreased expression of TGFB1 mRNA; Ursodeoxycholic Acid results in decreased expression of TGFB1 protein
CTD PMID:10510466 PMID:14514686 PMID:15222754 PMID:18479249 PMID:19493473 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TGFBI mRNA CTD PMID:15885361 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TGM2 mRNA CTD PMID:15885361 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Ursodeoxycholic Acid results in decreased expression of THRSP mRNA CTD PMID:15885361 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tmem176b transmembrane protein 176B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TMEM176B mRNA CTD PMID:15885361 NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased secretion of CXCL8 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL2 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL5 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CXCL8 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of IL6 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of NFKB1 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased secretion of IL6 protein]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP7 protein]; Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA]
Ursodeoxycholic Acid results in decreased secretion of TNF protein
Ursodeoxycholic Acid results in decreased expression of TNF mRNA; Ursodeoxycholic Acid results in decreased expression of TNF protein
Ursodeoxycholic Acid affects the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of TNF mRNA]
Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF mRNA]
CTD PMID:17438113 PMID:17888421 PMID:18590720 PMID:21146893 PMID:21274875 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA] CTD PMID:21146893 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
affects response to substance
increases ubiquitination
ISO
EXP
MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]
Ursodeoxycholic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
Ursodeoxycholic Acid affects the localization of TP53 protein
TP53 protein affects the susceptibility to Ursodeoxycholic Acid
[Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; Ursodeoxycholic Acid affects the localization of and results in decreased phosphorylation of TP53 protein; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of TP53 mRNA]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of and results in increased localization of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]; Ursodeoxycholic Acid results in increased ubiquitination of and results in increased degradation of TP53 protein
CTD PMID:14514686 PMID:15222754 PMID:17431217 PMID:17881359 PMID:18558085 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Ursodeoxycholic Acid results in increased expression of TRIB3 mRNA CTD PMID:15885361 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Ubd ubiquitin D decreases expression EXP Ursodeoxycholic Acid results in decreased expression of UBD mRNA CTD PMID:15885361 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in increased expression of UGT1A1 mRNA
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 protein]
CTD PMID:18687751 PMID:32198087 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
multiple interactions
ISO UGT1A3 protein results in increased glucuronidation of Ursodeoxycholic Acid
[Lapatinib results in decreased activity of UGT1A3 protein] which results in decreased glucuronidation of Ursodeoxycholic Acid
CTD PMID:31299240 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions
increases glucuronidation
EXP
ISO
Ursodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased activity of UGT2B1 protein]; Ursodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased expression of UGT2B1 protein]
UGT2B17 protein results in increased glucuronidation of Ursodeoxycholic Acid
CTD PMID:12663690 PMID:31299240 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Wdr33 WD repeat domain 33 affects expression ISO Ursodeoxycholic Acid affects the expression of WDR33 mRNA CTD PMID:18422935 NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of WIF1 mRNA CTD PMID:15885361 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link
glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Edn1 endothelin 1 decreases expression ISO glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
tauroursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression EXP ursodoxicoltaurine results in decreased expression of A2M mRNA CTD PMID:15885361 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Aadat aminoadipate aminotransferase decreases expression EXP ursodoxicoltaurine results in decreased expression of AADAT mRNA CTD PMID:15885361 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Aatf apoptosis antagonizing transcription factor increases expression EXP ursodoxicoltaurine results in increased expression of AATF mRNA CTD PMID:15885361 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
increases expression
EXP ursodoxicoltaurine results in decreased expression of ABCB11 mRNA
ursodoxicoltaurine results in increased expression of and results in increased activity of ABCB11 protein
ursodoxicoltaurine results in increased expression of ABCB11 protein
CTD PMID:11672435 PMID:12644037 PMID:15885361 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP ursodoxicoltaurine results in increased expression of and results in increased activity of ABCC2 protein
ursodoxicoltaurine results in increased expression of ABCC2 protein
CTD PMID:11672435 PMID:12644037 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP ursodoxicoltaurine results in increased expression of ABCC3 protein CTD PMID:11672435 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acly ATP citrate lyase decreases expression EXP ursodoxicoltaurine results in decreased expression of ACLY mRNA CTD PMID:15885361 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of ACSL1 mRNA CTD PMID:15885361 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of ACTN1 mRNA CTD PMID:15885361 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP ursodoxicoltaurine results in decreased expression of ADH1 mRNA CTD PMID:15885361 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adk adenosine kinase decreases expression EXP ursodoxicoltaurine results in decreased expression of ADK mRNA CTD PMID:15885361 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP ursodoxicoltaurine results in decreased expression of AGT mRNA
ursodoxicoltaurine inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased expression of FN1 protein]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein]
CTD PMID:15885361 PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
increases secretion
ISO AHR gene mutant form results in increased abundance of ursodoxicoltaurine
AHR gene mutant form results in increased secretion of ursodoxicoltaurine
CTD PMID:32679164 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP ursodoxicoltaurine results in increased expression of AKR1B8 mRNA CTD PMID:15885361 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression EXP ursodoxicoltaurine results in decreased expression of AKR1D1 mRNA CTD PMID:15885361 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; ursodoxicoltaurine results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:12721362 PMID:25398788 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Amy1a amylase, alpha 1A decreases expression EXP ursodoxicoltaurine results in decreased expression of AMY1A mRNA CTD PMID:15885361 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression
decreases expression
EXP ursodoxicoltaurine affects the expression of APAF1 mRNA; ursodoxicoltaurine affects the expression of APAF1 protein
ursodoxicoltaurine results in decreased expression of APAF1 mRNA
CTD PMID:15885361 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP ursodoxicoltaurine results in decreased expression of APOA1 mRNA CTD PMID:15885361 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [ursodoxicoltaurine co-treated with Indomethacin] results in increased expression of APOB mRNA; [ursodoxicoltaurine co-treated with Tunicamycin] results in increased expression of APOB mRNA; ursodoxicoltaurine inhibits the reaction [Allopurinol results in decreased secretion of APOB protein]; ursodoxicoltaurine inhibits the reaction [Fluorouracil results in decreased expression of APOB mRNA]; ursodoxicoltaurine inhibits the reaction [Rifampin results in decreased expression of APOB mRNA]; ursodoxicoltaurine inhibits the reaction [Tunicamycin results in decreased secretion of APOB protein] CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased activity of CASP2 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased activity of CASP6 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased expression of TRP53 protein]
ursodoxicoltaurine affects the reaction [APP protein modified form affects the localization of NR3C2 protein]; ursodoxicoltaurine inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein]; ursodoxicoltaurine inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]
CTD PMID:16728529 PMID:16923170 PMID:18368144 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP ursodoxicoltaurine results in decreased expression of AQP8 mRNA CTD PMID:15885361 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Arg1 arginase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of ARG1 mRNA CTD PMID:15885361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP ursodoxicoltaurine results in increased expression of ARL1 mRNA CTD PMID:15885361 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
JBrowse link
G As3mt arsenite methyltransferase decreases expression EXP ursodoxicoltaurine results in decreased expression of AS3MT mRNA CTD PMID:15885361 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
JBrowse link
G Atf4 activating transcription factor 4 decreases expression
multiple interactions
ISO ursodoxicoltaurine results in decreased expression of ATF4 mRNA
ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]
ursodoxicoltaurine inhibits the reaction [Quercetin results in increased expression of ATF4 protein]
CTD PMID:24312631 PMID:25611565 PMID:28223344 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [Quercetin results in increased activity of ATF6 protein]
ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]
CTD PMID:20165829 PMID:25611565 PMID:28223344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in decreased activity of BAD protein]; ursodoxicoltaurine results in increased phosphorylation of and results in decreased activity of BAD protein
ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein; Wortmannin inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein]
ursodoxicoltaurine results in increased phosphorylation of BAD protein
CTD PMID:12721362 PMID:15190125 PMID:17559149 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
ISO
EXP
ursodoxicoltaurine affects the localization of and results in decreased susceptibility to BAX protein; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased expression of BAX protein]
ursodoxicoltaurine results in decreased expression of BAX protein
ursodoxicoltaurine inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]; ursodoxicoltaurine inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]
ursodoxicoltaurine results in increased expression of BAX protein
CTD PMID:11080188 PMID:12627974 PMID:12721362 PMID:15255934 PMID:16923170 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP
ISO
ursodoxicoltaurine results in increased expression of BCL2 mRNA; ursodoxicoltaurine results in increased expression of BCL2 protein
ursodoxicoltaurine inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]
CTD PMID:12721362 PMID:15255934 PMID:16923170 PMID:25611565 PMID:29751043 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of BCL2L1 mRNA CTD PMID:12721362 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP ursodoxicoltaurine results in decreased expression of C4B mRNA CTD PMID:15885361 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Calr calreticulin multiple interactions EXP ursodoxicoltaurine promotes the reaction [Cisplatin results in increased expression of CALR mRNA] CTD PMID:33631298 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Canx calnexin multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Tunicamycin results in increased expression of CANX protein] CTD PMID:27588471 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein]
ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased cleavage of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of CASP12 mRNA]
CTD PMID:12198651 PMID:33631298 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp2 caspase 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased activity of CASP2 protein] CTD PMID:16923170 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP
ISO
ursodoxicoltaurine inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein]; ursodoxicoltaurine inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Neurotoxins results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of CASP3 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]
ursodoxicoltaurine inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
ursodoxicoltaurine results in decreased activity of CASP3 protein
CTD PMID:12198651 PMID:12773247 PMID:15190125 PMID:15222754 PMID:17436368 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP4 protein] CTD PMID:17559149 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp6 caspase 6 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased activity of CASP6 protein] CTD PMID:16923170 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased activity of CASP7 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] CTD PMID:12198651 PMID:17559149 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Chenodeoxycholic Acid co-treated with ursodoxicoltaurine] results in increased activity of CASP9 protein; ursodoxicoltaurine inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein] CTD PMID:12773247 PMID:14976352 PMID:25611565 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of CCN2 mRNA CTD PMID:15885361 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP ursodoxicoltaurine inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein]
ursodoxicoltaurine results in decreased expression of CCND1 mRNA; ursodoxicoltaurine results in decreased expression of CCND1 protein
CTD PMID:15885361 PMID:17431217 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh17 cadherin 17 decreases expression EXP ursodoxicoltaurine results in decreased expression of CDH17 mRNA CTD PMID:15885361 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of CDH2 mRNA CTD PMID:15885361 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP ursodoxicoltaurine results in increased expression of CEBPD mRNA CTD PMID:15885361 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of CHAC1 protein] CTD PMID:32275922 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of CITED2 mRNA CTD PMID:15885361 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of CPS1 mRNA CTD PMID:15885361 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in increased activity of CREB1 protein]; calphostin C inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in increased activity of CREB1 protein]; KN 62 inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in increased activity of CREB1 protein]; ursodoxicoltaurine results in increased phosphorylation of and results in increased activity of CREB1 protein CTD PMID:15861431 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cs citrate synthase multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] CTD PMID:28223344 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP ursodoxicoltaurine results in decreased expression of CSAD mRNA CTD PMID:15885361 NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP ursodoxicoltaurine results in decreased expression of CTH mRNA CTD PMID:15885361 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP1A2 mRNA CTD PMID:15885361 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP27A1 mRNA CTD PMID:15885361 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP2A2 mRNA CTD PMID:15885361 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP2B3 mRNA CTD PMID:15885361 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP2C12 mRNA CTD PMID:15885361 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP2F4 mRNA CTD PMID:15885361 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of CYP4F1 mRNA CTD PMID:15885361 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO
ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]
ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA]
ursodoxicoltaurine inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]
CTD PMID:23544086 PMID:24802810 PMID:25611565 PMID:27853103 PMID:28223344 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP ursodoxicoltaurine results in decreased expression of DPP4 mRNA CTD PMID:15885361 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G E2f1 E2F transcription factor 1 increases expression
decreases expression
EXP ursodoxicoltaurine results in increased expression of E2F1 mRNA
ursodoxicoltaurine results in decreased expression of E2F1 protein
CTD PMID:15255934 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Edn1 endothelin 1 decreases expression ISO ursodoxicoltaurine results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810 PMID:25611565 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of ENPP1 mRNA CTD PMID:15885361 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Ergic3 ERGIC and golgi 3 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Tunicamycin results in decreased expression of ERGIC3 protein] CTD PMID:27588471 NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:29031535 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Dronabinol results in increased expression of ESRRG mRNA] CTD PMID:31054322 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO ursodoxicoltaurine results in decreased expression of FABP4 mRNA CTD PMID:24312631 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of FADS1 mRNA CTD PMID:15885361 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads3 fatty acid desaturase 3 decreases expression EXP ursodoxicoltaurine results in decreased expression of FADS3 mRNA CTD PMID:15885361 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression EXP ursodoxicoltaurine results in decreased expression of FAH mRNA CTD PMID:15885361 NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP ursodoxicoltaurine results in decreased expression of FAS mRNA CTD PMID:14623915 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Dronabinol results in increased expression of FLT1 mRNA] CTD PMID:31054322 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 decreases expression EXP ursodoxicoltaurine results in decreased expression of FMO3 mRNA CTD PMID:15885361 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP ursodoxicoltaurine results in decreased expression of FN1 mRNA
ursodoxicoltaurine inhibits the reaction [AGT protein results in increased expression of FN1 protein]
CTD PMID:15885361 PMID:25398788 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of FOS mRNA] CTD PMID:18164257 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol results in decreased acetylation of FOXO1 protein] CTD PMID:23544086 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase decreases expression EXP ursodoxicoltaurine results in decreased expression of FTCD mRNA CTD PMID:15885361 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of G6PC1 mRNA]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of G6PC1 protein] CTD PMID:23544086 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP ursodoxicoltaurine results in decreased expression of GAMT mRNA CTD PMID:15885361 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gckr glucokinase regulator decreases expression EXP ursodoxicoltaurine results in decreased expression of GCKR mRNA CTD PMID:15885361 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of GLUD1 mRNA CTD PMID:15885361 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 decreases expression ISO ursodoxicoltaurine results in decreased expression of GPBAR1 mRNA CTD PMID:24312631 NCBI chr 9:75,862,151...75,863,140
Ensembl chr 9:75,860,677...75,863,168
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP ursodoxicoltaurine results in decreased expression of GSTA5 mRNA CTD PMID:15885361 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP ursodoxicoltaurine results in decreased expression of GSTM3 mRNA CTD PMID:15885361 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP ursodoxicoltaurine results in increased expression of GSTP1 mRNA CTD PMID:15885361 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression EXP ursodoxicoltaurine results in decreased expression of HAAO mRNA CTD PMID:15885361 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression EXP ursodoxicoltaurine results in decreased expression of HADH mRNA CTD PMID:15885361 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression EXP ursodoxicoltaurine results in increased expression of HBP1 mRNA CTD PMID:15885361 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]] CTD PMID:23544086 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC4 protein] CTD PMID:23544086 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC5 protein] CTD PMID:23544086 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac7 histone deacetylase 7 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC7 protein] CTD PMID:23544086 NCBI chr 7:128,923,918...128,962,025
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of HDHD2 mRNA CTD PMID:15885361 NCBI chr18:70,475,037...70,526,471
Ensembl chr18:70,474,926...70,526,470
JBrowse link
G Hpn hepsin decreases expression EXP ursodoxicoltaurine results in decreased expression of HPN mRNA CTD PMID:15885361 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression EXP ursodoxicoltaurine results in decreased expression of HRG mRNA CTD PMID:15885361 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression
multiple interactions
decreases abundance
EXP
ISO
ursodoxicoltaurine results in decreased expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
HSD11B1 gene mutant form results in decreased abundance of ursodoxicoltaurine
CTD PMID:15885361 PMID:25061560 PMID:26803847 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP ursodoxicoltaurine results in decreased expression of HSD17B6 mRNA CTD PMID:15885361 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]
ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]
ursodoxicoltaurine results in increased expression of HSPA5 protein
ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Quercetin results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of HSPA5 protein]
CTD PMID:12198651 PMID:20165829 PMID:24802810 PMID:25160872 PMID:25611565 More... NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of IGF1 mRNA CTD PMID:15885361 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP ursodoxicoltaurine results in increased expression of IGFBP1 mRNA CTD PMID:15885361 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il10 interleukin 10 increases abundance ISO IL10 gene mutant form results in increased abundance of ursodoxicoltaurine CTD PMID:27580383 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein] CTD PMID:29031535 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein] CTD PMID:29031535 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]] CTD PMID:20165829 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA] CTD PMID:28223344 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of JUN mRNA] CTD PMID:18164257 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kng2 kininogen 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of KNG2 mRNA CTD PMID:15885361 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lgals5 galectin 5 decreases expression EXP ursodoxicoltaurine results in decreased expression of LGALS5 mRNA CTD PMID:15885361 NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
JBrowse link
G Lgals9 galectin 9 decreases expression EXP ursodoxicoltaurine results in decreased expression of LGALS9 mRNA CTD PMID:15885361 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Limk2 LIM domain kinase 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of LIMK2 mRNA CTD PMID:15885361 NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007
JBrowse link
G Lmbrd1 LMBR1 domain containing 1 increases expression EXP ursodoxicoltaurine results in increased expression of LMBRD1 mRNA CTD PMID:15885361 NCBI chr 9:27,096,387...27,178,095
Ensembl chr 9:27,096,297...27,178,090
JBrowse link
G Lox lysyl oxidase decreases expression EXP ursodoxicoltaurine results in decreased expression of LOX mRNA CTD PMID:15885361 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Maob monoamine oxidase B decreases expression EXP ursodoxicoltaurine results in decreased expression of MAOB mRNA CTD PMID:15885361 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP ursodoxicoltaurine inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein] CTD PMID:18368144 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Masp2 MBL associated serine protease 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of MASP2 mRNA CTD PMID:15885361 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP ursodoxicoltaurine results in increased expression of MDM2 mRNA CTD PMID:15885361 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA] CTD PMID:28223344 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO ursodoxicoltaurine inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of MX2 mRNA CTD PMID:15885361 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
JBrowse link
G Nfia nuclear factor I/A decreases expression EXP ursodoxicoltaurine results in decreased expression of NFIA mRNA CTD PMID:15885361 NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP ursodoxicoltaurine results in increased expression of NFKBIA protein CTD PMID:12721362 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] CTD PMID:29031535 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of NOS2 mRNA]; ursodoxicoltaurine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein] CTD PMID:29751043 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP ursodoxicoltaurine results in increased expression of NR1D2 mRNA CTD PMID:15885361 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; ursodoxicoltaurine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]
[ursodoxicoltaurine co-treated with TGFB1 protein] results in increased localization of NR3C1 protein
CTD PMID:15222754 PMID:15885359 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding
increases expression
increases localization
multiple interactions
EXP ursodoxicoltaurine binds to NR3C2 protein
ursodoxicoltaurine results in increased expression of NR3C2 mRNA
ursodoxicoltaurine results in increased localization of NR3C2 protein
[ursodoxicoltaurine binds to NR3C2 protein] which affects the localization of NR3C2 protein; [ursodoxicoltaurine co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; ursodoxicoltaurine affects the reaction [APP protein modified form affects the localization of NR3C2 protein]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]
CTD PMID:15222754 PMID:16728529 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nup62 nucleoporin 62 increases expression EXP ursodoxicoltaurine results in increased expression of NUP62 mRNA CTD PMID:15885361 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of OS9 mRNA] CTD PMID:33631298 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP ursodoxicoltaurine results in decreased expression of OTC mRNA CTD PMID:15885361 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA] CTD PMID:28223344 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583
JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP ursodoxicoltaurine results in decreased expression of PAH mRNA CTD PMID:15885361 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Chenodeoxycholic Acid co-treated with ursodoxicoltaurine] results in increased cleavage of PARP1 protein; ursodoxicoltaurine inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]] CTD PMID:14976352 PMID:25611565 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol results in decreased acetylation of PCK1 protein]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of PCK1 mRNA]; ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of PCK1 protein] CTD PMID:23544086 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of PDLIM1 mRNA CTD PMID:15885361 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase decreases expression EXP ursodoxicoltaurine results in decreased expression of PECR mRNA CTD PMID:15885361 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression EXP ursodoxicoltaurine results in decreased expression of PHYH mRNA CTD PMID:15885361 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance ISO POR gene mutant form affects the abundance of ursodoxicoltaurine CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases abundance ISO PPARA gene mutant form results in decreased abundance of ursodoxicoltaurine CTD PMID:29175453 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein] CTD PMID:20165829 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein] CTD PMID:16923170 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of RB1 protein CTD PMID:15255934 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rnf138 ring finger protein 138 increases expression EXP ursodoxicoltaurine results in increased expression of RNF138 mRNA CTD PMID:15885361 NCBI chr18:12,291,557...12,315,931 JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP ursodoxicoltaurine results in increased expression of RT1-EC2 mRNA CTD PMID:15885361
G S100a6 S100 calcium binding protein A6 decreases expression EXP ursodoxicoltaurine results in decreased expression of S100A6 mRNA CTD PMID:15885361 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G Scarb2 scavenger receptor class B, member 2 increases expression EXP ursodoxicoltaurine results in increased expression of SCARB2 mRNA CTD PMID:15885361 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP ursodoxicoltaurine results in decreased expression of SCD1 mRNA CTD PMID:15885361 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of SCP2 mRNA CTD PMID:15885361 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression EXP ursodoxicoltaurine results in increased expression of SERP1 mRNA CTD PMID:15885361 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116
JBrowse link
G Serpina1 serpin family A member 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased activity of CASP7 protein]; ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP4 protein] CTD PMID:17559149 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpind1 serpin family D member 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of SERPIND1 mRNA CTD PMID:15885361 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 decreases expression EXP ursodoxicoltaurine results in decreased expression of SH3BP5 mRNA CTD PMID:15885361 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Sirt2 sirtuin 2 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] CTD PMID:23544086 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP ursodoxicoltaurine results in increased expression of SLC10A2 protein CTD PMID:11672435 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP ursodoxicoltaurine results in decreased expression of SLC22A8 mRNA CTD PMID:15885361 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc26a1 solute carrier family 26 member 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of SLC26A1 mRNA CTD PMID:15885361 NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of SLC27A2 mRNA CTD PMID:15885361 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP ursodoxicoltaurine results in decreased expression of SLC37A4 mRNA CTD PMID:15885361 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc38a3 solute carrier family 38, member 3 decreases expression EXP ursodoxicoltaurine results in decreased expression of SLC38A3 mRNA CTD PMID:15885361 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression EXP ursodoxicoltaurine results in increased expression of SLC6A9 mRNA CTD PMID:15885361 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Smad3 SMAD family member 3 increases abundance ISO SMAD3 protein results in increased abundance of ursodoxicoltaurine CTD PMID:23034213 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snca synuclein alpha multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]; ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] CTD PMID:16239214 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]] CTD PMID:25398788 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Quercetin results in decreased phosphorylation of STAT3 protein] CTD PMID:25611565 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stmn1 stathmin 1 increases expression EXP ursodoxicoltaurine results in increased expression of STMN1 mRNA CTD PMID:15885361 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of SULT1A1 mRNA CTD PMID:15885361 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of SULT1B1 mRNA CTD PMID:15885361 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tagln transgelin decreases expression EXP ursodoxicoltaurine results in decreased expression of TAGLN mRNA CTD PMID:15885361 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases expression EXP ursodoxicoltaurine results in decreased expression of TDO2 mRNA CTD PMID:15885361 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [ursodoxicoltaurine co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; [ursodoxicoltaurine co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; ursodoxicoltaurine inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; ursodoxicoltaurine inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]; ursodoxicoltaurine inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein] CTD PMID:15222754 PMID:25398788 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression EXP ursodoxicoltaurine results in decreased expression of TGFBI mRNA CTD PMID:15885361 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP ursodoxicoltaurine results in decreased expression of TGM2 mRNA CTD PMID:15885361 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP ursodoxicoltaurine results in decreased expression of THRSP mRNA CTD PMID:15885361 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 decreases expression EXP ursodoxicoltaurine results in decreased expression of TM4SF4 mRNA CTD PMID:15885361 NCBI chr 2:141,570,321...141,621,263
Ensembl chr 2:141,481,902...141,621,200
JBrowse link
G Tmem37 transmembrane protein 37 decreases expression EXP ursodoxicoltaurine results in decreased expression of TMEM37 mRNA CTD PMID:15885361 NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
EXP
ISO
ursodoxicoltaurine inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; ursodoxicoltaurine results in increased expression of and results in increased stability of TP53 protein
ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased expression of TRP53 protein]
TP53 protein affects the susceptibility to ursodoxicoltaurine
CTD PMID:15255934 PMID:16923170 PMID:17431217 PMID:17881359 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of UGGT1 mRNA]; ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of UGGT1 protein] CTD PMID:33631298 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP ursodoxicoltaurine results in decreased expression of UGT2B mRNA CTD PMID:15885361 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP ursodoxicoltaurine results in decreased expression of UPB1 mRNA CTD PMID:15885361 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO ursodoxicoltaurine inhibits the reaction [Dronabinol results in increased expression of VEGFA mRNA] CTD PMID:31054322 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP
ISO
ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]
ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; ursodoxicoltaurine inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]
CTD PMID:20165829 PMID:25611565 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19732
          heteroatomic molecular entity 19673
            hydroxides 19175
              organic hydroxy compound 18668
                hydroxy-5beta-cholanic acid 926
                  dihydroxy-5beta-cholanic acid 774
                    ursodeoxycholic acid 389
                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                      glycoursodeoxycholic acid 4
                      tauroursodeoxycholic acid 190
                      ursodeoxycholoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic polycyclic compound 16535
                                  steroid 13057
                                    steroid fundamental parent 12693
                                      cholane 942
                                        cholanoid 942
                                          cholanic acids 926
                                            cholanic acid 926
                                              5beta-cholanic acid 926
                                                hydroxy-5beta-cholanic acid 926
                                                  dihydroxy-5beta-cholanic acid 774
                                                    ursodeoxycholic acid 389
                                                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                                                      glycoursodeoxycholic acid 4
                                                      tauroursodeoxycholic acid 190
                                                      ursodeoxycholoyl-CoA 0
paths to the root