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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cudratricusxanthone A
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Accession:CHEBI:65686 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.
Synonyms:exact_synonym: 2,3,6,8-tetrahydroxy-5-(2-methylbut-3-en-2-yl)-1-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: CTXA;   Formula=C23H24O6;   InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3;   InChIKey=FUEJTEBWTNXAPG-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C
 xref_mesh: MESH:C533013
 xref: PMID:15787460;   PMID:17409526;   PMID:18683128;   PMID:19084080;   Reaxys:9817853


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cudratricusxanthone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnb1 interferon beta 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein] CTD PMID:31350693 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein] CTD PMID:31350693 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the phosphorylation of and affects the expression of and affects the localization of JUN protein] CTD PMID:31350693 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:31350693 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:31350693 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31350693 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein] CTD PMID:31350693 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:31350693 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TICAM1 protein] CTD PMID:31350693 NCBI chr 9:1,102,559...1,115,573
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31350693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31350693 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        anti-inflammatory agent 16435
          cudratricusxanthone A 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      ketone 17091
                                        cyclic ketone 15644
                                          xanthones 175
                                            cudratricusxanthone A 11
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