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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cudratricusxanthone A
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Accession:CHEBI:65686 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.
Synonyms:exact_synonym: 2,3,6,8-tetrahydroxy-5-(2-methylbut-3-en-2-yl)-1-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
 related_synonym: CTXA;   Formula=C23H24O6;   InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3;   InChIKey=FUEJTEBWTNXAPG-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C
 xref_mesh: MESH:C533013
 xref: PMID:15787460;   PMID:17409526;   PMID:18683128;   PMID:19084080;   Reaxys:9817853



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cudratricusxanthone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnb1 interferon beta 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein] CTD PMID:31350693 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein] CTD PMID:31350693 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the phosphorylation of and affects the expression of and affects the localization of JUN protein] CTD PMID:31350693 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:31350693 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:31350693 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31350693 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein] CTD PMID:31350693 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:31350693 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TICAM1 protein] CTD PMID:31350693 NCBI chr 9:1,102,559...1,115,573 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31350693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31350693 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        anti-inflammatory agent 15835
          cudratricusxanthone A 11
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        cyclic ketone 15393
                                          xanthones 174
                                            cudratricusxanthone A 11
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