CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cudratricusxanthone A
Accession: CHEBI:65686
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Definition: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.
Synonyms: exact_synonym: 2,3,6,8-tetrahydroxy-5-(2-methylbut-3-en-2-yl)-1-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
related_synonym: CTXA; Formula=C23H24O6; InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3; InChIKey=FUEJTEBWTNXAPG-UHFFFAOYSA-N; SMILES=CC(C)=CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C
xref_mesh: MESH:C533013
xref: PMID:15787460; PMID:17409526; PMID:18683128; PMID:19084080; Reaxys:9817853
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Ifnb1
interferon beta 1
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein]
CTD
PMID:31350693
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:108,066,650...108,067,487
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Irf3
interferon regulatory factor 3
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein]
CTD
PMID:31350693
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:104,616,469...104,621,401
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the phosphorylation of and affects the expression of and affects the localization of JUN protein]
CTD
PMID:31350693
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:31350693
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:31350693
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]
CTD
PMID:31350693
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]
CTD
PMID:31350693
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD
PMID:31350693
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Ticam1
TIR domain containing adaptor molecule 1
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TICAM1 protein]
CTD
PMID:31350693
NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,172,963...1,196,892
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Tlr4
toll-like receptor 4
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
CTD
PMID:31350693
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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Tnf
tumor necrosis factor
multiple interactions
ISO
cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:31350693
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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