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ONTOLOGY REPORT - ANNOTATIONS


Term:clobenpropit
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Accession:CHEBI:64177 term browser browse the term
Definition:An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Synonyms:exact_synonym: 3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate
 related_synonym: Formula=C14H17ClN4S;   InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);   InChIKey=UCAIEVHKDLMIFL-UHFFFAOYSA-N;   S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea;   SMILES=Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1
 xref: CAS:145231-45-4 "ChemIDplus";   CAS:145231-45-4 "KEGG COMPOUND";   KEGG:C17934;   LINCS:LSM-3600
 xref_mesh: MESH:C086108
 xref: PMID:19895842 "Europe PMC";   PMID:20014479 "Europe PMC";   PMID:20093321 "Europe PMC";   PMID:20197375 "Europe PMC";   PMID:20432621 "Europe PMC";   PMID:20511290 "Europe PMC";   PMID:21134907 "Europe PMC";   PMID:21272571 "Europe PMC";   PMID:21554104 "Europe PMC";   PMID:21793031 "Europe PMC";   PMID:22003888 "Europe PMC";   PMID:22005500 "Europe PMC";   PMID:22011436 "Europe PMC";   PMID:22115898 "Europe PMC";   PMID:22331799 "Europe PMC";   Reaxys:5822910 "Reaxys";   Wikipedia:Clobenpropit
 cyclic_relationship: is_conjugate_base_of CHEBI:64193


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clobenpropit term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Hrh3 histamine receptor H3 JBrowse link 3 175,474,310 175,479,395 RGD:6480464
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          antagonist 15784
            histamine antagonist 4485
              H3-receptor antagonist 14
                clobenpropit 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  heteroarene 15146
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8040
                                          imidazoles 7591
                                            clobenpropit 14
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