The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein] [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit
clobenpropit binds to and results in decreased activity of HRH3 protein; clobenpropit inhibits the reaction [[Methylhistamines binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium] [4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit; [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine; clobenpropit binds to and results in decreased activity of HRH3 protein clobenpropit analog binds to HRH3 protein; clobenpropit binds to HRH3 protein
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]; [clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein; clobenpropit binds to and results in increased activity of HRH4 protein clobenpropit binds to HRH4 protein
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