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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:agathisflavone
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Accession:CHEBI:2512 term browser browse the term
Definition:A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-6 and C-8 of the two chromene rings.
Synonyms:exact_synonym: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-6,8'-bichromene-4,4'-dione
 related_synonym: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-(6,8'-bi-4H-1-benzopyran)-4,4'-dione;   6,8''-Biapigenin;   Formula=C30H18O10;   InChI=1S/C30H18O10/c31-15-5-1-13(2-6-15)22-11-20(36)26-24(39-22)12-21(37)27(29(26)38)28-18(34)9-17(33)25-19(35)10-23(40-30(25)28)14-3-7-16(32)8-4-14/h1-12,31-34,37-38H;   InChIKey=BACLASYRJRZXMY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(c(O)cc2o1)-c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1
 xref: Beilstein:1415839;   CAS:28441-98-7;   KEGG:C10017;   KNApSAcK:C00001014
 xref_mesh: MESH:C079168
 xref: PMID:1484886;   PMID:21106357;   PMID:21281018;   PMID:21594945;   Patent:US2002068757;   Patent:WO9700679;   Reaxys:1415839


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agathisflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of ARG1 mRNA] CTD PMID:29425760 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BDNF mRNA]
agathisflavone results in increased expression of BDNF mRNA
CTD PMID:29425760 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of CASP3 protein modified form] CTD PMID:29425760 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdnf cerebral dopamine neurotrophic factor increases expression EXP agathisflavone results in increased expression of CDNF mRNA CTD PMID:29425760 NCBI chr17:78,721,230...78,735,324
Ensembl chr17:78,719,111...78,735,324
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of GDNF mRNA] CTD PMID:29425760 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of GLUL protein CTD PMID:29425760 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA]
agathisflavone results in increased expression of IL10 mRNA
CTD PMID:29425760 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL1B mRNA] CTD PMID:29425760 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL6 mRNA]
agathisflavone results in increased expression of IL6 mRNA
CTD PMID:29425760 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of ITGAM protein] CTD PMID:29425760 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression EXP agathisflavone results in increased expression of MRC1 protein CTD PMID:29425760 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NGF mRNA CTD PMID:29425760 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ntf4 neurotrophin 4 multiple interactions
increases expression
EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NTF4 mRNA
agathisflavone results in increased expression of NTF4 mRNA
CTD PMID:29425760 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression
multiple interactions
EXP agathisflavone results in increased expression of SLC1A3 protein
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein]
CTD PMID:29425760 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of TNF mRNA] CTD PMID:29425760 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antiviral agent 10245
            agathisflavone 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        flavonoid 6372
                                          flavones 4166
                                            hydroxyflavone 4154
                                              agathisflavone 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.