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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:agathisflavone
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Accession:CHEBI:2512 term browser browse the term
Definition:A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-6 and C-8 of the two chromene rings.
Synonyms:exact_synonym: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-6,8'-bichromene-4,4'-dione
 related_synonym: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-(6,8'-bi-4H-1-benzopyran)-4,4'-dione;   6,8''-Biapigenin;   Formula=C30H18O10;   InChI=1S/C30H18O10/c31-15-5-1-13(2-6-15)22-11-20(36)26-24(39-22)12-21(37)27(29(26)38)28-18(34)9-17(33)25-19(35)10-23(40-30(25)28)14-3-7-16(32)8-4-14/h1-12,31-34,37-38H;   InChIKey=BACLASYRJRZXMY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(c(O)cc2o1)-c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1
 xref: CAS:28441-98-7;   KEGG:C10017;   KNApSAcK:C00001014
 xref_mesh: MESH:C079168
 xref: PMID:1484886;   PMID:21106357;   PMID:21281018;   PMID:21594945;   Patent:US2002068757;   Patent:WO9700679;   Reaxys:1415839


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agathisflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of ARG1 mRNA] CTD PMID:29425760 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression 		EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BDNF mRNA]
agathisflavone results in increased expression of BDNF mRNA 		CTD PMID:29425760 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of CASP3 protein modified form] CTD PMID:29425760 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdnf cerebral dopamine neurotrophic factor increases expression EXP agathisflavone results in increased expression of CDNF mRNA CTD PMID:29425760 NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of GDNF mRNA] CTD PMID:29425760 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of GLUL protein CTD PMID:29425760 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression 		EXP agathisflavone promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA]
agathisflavone results in increased expression of IL10 mRNA 		CTD PMID:29425760 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL1B mRNA] CTD PMID:29425760 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of IL6 mRNA]
agathisflavone results in increased expression of IL6 mRNA 		CTD PMID:29425760 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of ITGAM protein] CTD PMID:29425760 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression EXP agathisflavone results in increased expression of MRC1 protein CTD PMID:29425760 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NGF mRNA CTD PMID:29425760 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ntf4 neurotrophin 4 multiple interactions
increases expression 		EXP [agathisflavone co-treated with Excitatory Amino Acid Agonists] results in increased expression of NTF4 mRNA
agathisflavone results in increased expression of NTF4 mRNA 		CTD PMID:29425760 NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression
multiple interactions 		EXP agathisflavone results in increased expression of SLC1A3 protein
agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC1A3 protein] 		CTD PMID:29425760 NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP agathisflavone inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of TNF mRNA] CTD PMID:29425760 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          antiviral agent 11451
            agathisflavone 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  oxacycle 18292
                                    benzopyran 12079
                                      1-benzopyran 11825
                                        flavonoid 7283
                                          anthoxanthin 4619
                                            flavones 4619
                                              hydroxyflavone 4596
                                                agathisflavone 15
paths to the root