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dexamethasone phosphate - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dexamethasone phosphate
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Accession:CHEBI:68637 term browser browse the term
Definition:A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Synonyms:exact_synonym: (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
 related_synonym: Betnelan phosphate;   Dexamethasone 21-orthophosphate;   Dexamethasone-21-dihydrogen-phosphate;   Formula=C22H30FO8P;   Hexadrol phosphate;   InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=VQODGRNSFPNSQE-CXSFZGCWSA-N;   Neodecadron;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COP(O)(O)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
 xref: CAS:312-93-6;   Drug_Central:3920
 xref_mesh: MESH:C004180
 xref: PMID:19910302;   PMID:20003498;   PMID:20642832;   PMID:21629568;   PMID:22115712;   Reaxys:2230371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68638

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dexamethasone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]; dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLK mRNA] CTD PMID:36996615 NCBI chr15:41,802,701...41,841,004
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Blnk B-cell linker multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLNK protein] CTD PMID:36996615 NCBI chr 1:249,703,064...249,770,533
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:25447644 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd19 CD19 molecule multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of CD19 protein] CTD PMID:36996615 NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Cd22 CD22 molecule multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of CD22 mRNA] CTD PMID:36996615 NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:86,117,459...86,132,322 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fcgr2b Fc gamma receptor 2B multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA] CTD PMID:36996615 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fcrla Fc receptor-like A multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of FCRLA mRNA] CTD PMID:36996615 NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:36996615 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]; dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:36996615 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of MS4A1 protein] CTD PMID:36996615 NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:207,906,374...207,918,512 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dexamethasone 21-phosphate results in increased cleavage of PARP1 protein CTD PMID:25447644 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of POU2AF1 mRNA] CTD PMID:36996615 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:51,474,015...51,548,819 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]
dexamethasone 21-phosphate affects the localization of RELA protein		 CTD PMID:17931716 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO		 dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form		 CTD PMID:25447644 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,590,677...31,599,102 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]
dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:17931716 PMID:36996615 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        xenobiotic 18730
          dexamethasone 4587
            dexamethasone phosphate 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            hydroxides 19361
                              oxoacid 18797
                                pnictogen oxoacid 15018
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13927
                                      phosphoric acid 13927
                                        phosphoric acid derivative 13839
                                          phosphate 13838
                                            organic phosphate 13838
                                              steroid phosphate 20
                                                dexamethasone phosphate 20
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