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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(2E,4E)-hexa-2,4-dienoic acid
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Accession:CHEBI:38358 term browser browse the term
Definition:A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.
Synonyms:related_synonym: (2E,4E)-2,4-hexadienoic acid;   (E,E)-1,3-pentadiene-1-carboxylic acid;   (E,E)-2,4-hexadienoic acid;   (E,E)-SA;   (E,E)-sorbic acid;   1,3-pentadiene-1-carboxylic acid;   Formula=C6H8O2;   InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+;   InChIKey=WSWCOQWTEOXDQX-MQQKCMAXSA-N;   SA;   SMILES=C\\C=C\\C=C\\C(O)=O;   alpha-trans-gamma-trans-sorbic acid;   trans,trans-2,4-hexadienoic acid;   trans,trans-SA;   trans,trans-sorbic acid
 xref: Beilstein:1098547;   CAS:110-44-1;   Gmelin:260824;   Gmelin:3063;   LIPID_MAPS_instance:LMFA01030100
 xref_mesh: MESH:D013011
 xref: PMID:11206806;   PMID:7979442
 cyclic_relationship: is_conjugate_acid_of CHEBI:77869


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(2E,4E)-hexa-2,4-dienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Sorbic Acid results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Food Preservatives results in increased abundance of Sorbic Acid] which results in increased expression of IFNG mRNA CTD PMID:32179172 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Sorbic Acid] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Food Preservatives results in increased abundance of Sorbic Acid] which results in increased expression of IL1B mRNA CTD PMID:32179172 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Food Preservatives results in increased abundance of Sorbic Acid] which results in increased expression of IL6 mRNA CTD PMID:32179172 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Sorbic Acid results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Sorbic Acid results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sorbic Acid results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Food Preservatives results in increased abundance of Sorbic Acid] which results in increased expression of TNF mRNA CTD PMID:32179172 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Sorbic Acid results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19771
            organic molecular entity 19771
              lipid 17992
                fatty acid 16843
                  medium-chain fatty acid 6017
                    sorbic acid 10
                      (2E,4E)-hexa-2,4-dienoic acid 10
                        nigragillin 0
                        trans,trans-2,4-hexadienoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      monocarboxylic acid 18017
                                        fatty acid 16843
                                          unsaturated fatty acid 1685
                                            polyunsaturated fatty acid 847
                                              hexadienoic acid 10
                                                sorbic acid 10
                                                  (2E,4E)-hexa-2,4-dienoic acid 10
                                                    nigragillin 0
                                                    trans,trans-2,4-hexadienoyl-CoA 0
paths to the root