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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(2E,4E)-hexa-2,4-dienoic acid
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Accession:CHEBI:38358 term browser browse the term
Definition:A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.
Synonyms:related_synonym: (2E,4E)-2,4-hexadienoic acid;   (E,E)-1,3-pentadiene-1-carboxylic acid;   (E,E)-2,4-hexadienoic acid;   (E,E)-SA;   (E,E)-sorbic acid;   1,3-pentadiene-1-carboxylic acid;   Formula=C6H8O2;   InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+;   InChIKey=WSWCOQWTEOXDQX-MQQKCMAXSA-N;   SA;   SMILES=C\\C=C\\C=C\\C(O)=O;   alpha-trans-gamma-trans-sorbic acid;   trans,trans-2,4-hexadienoic acid;   trans,trans-SA;   trans,trans-sorbic acid
 xref: Beilstein:1098547;   CAS:110-44-1;   Gmelin:260824;   Gmelin:3063;   LIPID_MAPS_instance:LMFA01030100
 xref_mesh: MESH:D013011
 xref: PMID:11206806;   PMID:7979442
 cyclic_relationship: is_conjugate_acid_of CHEBI:77869


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(2E,4E)-hexa-2,4-dienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Sorbic Acid results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Sorbic Acid results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Sorbic Acid results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sorbic Acid results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Sorbic Acid results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      atom 19770
        nonmetal atom 19646
          carbon atom 19564
            organic molecular entity 19564
              lipid 17488
                fatty acid 16014
                  medium-chain fatty acid 3550
                    sorbic acid 5
                      (2E,4E)-hexa-2,4-dienoic acid 5
                        nigragillin 0
                        trans,trans-2,4-hexadienoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          fatty acid 16014
                                            unsaturated fatty acid 949
                                              polyunsaturated fatty acid 685
                                                hexadienoic acid 5
                                                  sorbic acid 5
                                                    (2E,4E)-hexa-2,4-dienoic acid 5
                                                      nigragillin 0
                                                      trans,trans-2,4-hexadienoyl-CoA 0
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