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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxarsone
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Accession:CHEBI:35817 term browser browse the term
Definition:An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.
Synonyms:exact_synonym: (4-hydroxy-3-nitrophenyl)arsonic acid
 related_synonym: 2-nitro-1-hydroxybenzene-4-arsonic acid;   3-Nitro;   3-nitro-4-hydroxybenzenearsonic acid;   3-nitro-4-hydroxyphenylarsonic acid;   4-hydroxy-3-nitrobenzenearsonic acid;   4-hydroxy-3-nitrophenylarsonic acid;   Formula=C6H6AsNO6;   InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12);   InChIKey=XMVJITFPVVRMHC-UHFFFAOYSA-N;   NSC-2101;   Ren-O-Sal;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[As](O)(O)=O;   roxarson;   roxarsonum
 xref: Beilstein:1976533;   CAS:121-19-7;   Gmelin:1221211;   LINCS:LSM-5383
 xref_mesh: MESH:D012406
 xref: PMID:12724787;   PMID:12731831;   PMID:12731832;   PMID:18414637;   PMID:21388897;   Patent:DE224953;   Patent:GB226255;   Reaxys:1976533;   VSDB:3003;   Wikipedia:Roxarsone


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roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 decreases expression ISO Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Cnmd chondromodulin decreases expression ISO Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr15:55,041,548...55,066,297
Ensembl chr15:55,041,561...55,066,297 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion ISO Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Fhdc1 FH2 domain containing 1 decreases expression ISO Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 2:169,790,917...169,829,580
Ensembl chr 2:169,790,947...169,827,896 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Lep leptin decreases expression ISO Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
multiple interactions		 EXP Roxarsone results in increased expression of MTOR mRNA
Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein]		 CTD PMID:35985552 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression
multiple interactions		 ISO Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein]		 CTD PMID:30028964 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plg plasminogen decreases expression ISO Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases expression		 EXP Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]
Roxarsone results in increased expression of RPS6KB1 mRNA		 CTD PMID:35985552 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      application 19668
        agrochemical 16712
          roxarsone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      chalcogen 19552
                        oxygen atom 19527
                          oxygen molecular entity 19527
                            hydroxides 19334
                              oxoacid 18769
                                pnictogen oxoacid 14889
                                  arsenic oxoacid 4240
                                    arsonic acids 637
                                      arsonic acid 637
                                        organoarsonic acid 637
                                          phenylarsonic acid 16
                                            roxarsone 14
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