Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cetirizine
go back to main search page
Accession:CHEBI:3561 term browser browse the term
Definition:A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Synonyms:exact_synonym: (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
 related_synonym: Cetirizin;   Formula=C21H25ClN2O3;   InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26);   InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N;   SMILES=OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1;   cetirizina;   cetirizinum
 xref: CAS:83881-51-0;   DrugBank:DB00341;   Drug_Central:581;   HMDB:HMDB0005032;   KEGG:C07778;   KEGG:D07662;   LINCS:LSM-1544
 xref_mesh: MESH:D017332
 xref: PMID:15850951;   PMID:20455340;   PMID:8103703;   Reaxys:7227333;   Wikipedia:Cetirizine



show annotations for term's descendants           Sort by:
cetirizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Cetirizine results in decreased expression of ABCB11 mRNA CTD PMID:24852568 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Cetirizine CTD PMID:12584158 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Cetirizine analog results in decreased activity of ALOX5 protein CTD PMID:15482930 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apoe apolipoprotein E multiple interactions
decreases expression
ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA; APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]; APOE protein results in decreased susceptibility to [Dietary Fats co-treated with Cetirizine]
Cetirizine results in decreased expression of APOE mRNA
CTD PMID:24852568 PMID:25020133 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein CTD PMID:25020133 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein CTD PMID:25020133 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Cetirizine analog results in decreased activity of CYP3A4 protein; Cetirizine results in decreased activity of CYP3A4 protein CTD PMID:15482930 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP Cetirizine affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO Cetirizine binds to and results in decreased activity of HRH1 protein
Cetirizine analog binds to HRH1 protein; Cetirizine binds to HRH1 protein
CTD PMID:15482930 PMID:16401869 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il4 interleukin 4 decreases expression ISO Cetirizine results in decreased expression of IL4 protein CTD PMID:19672097 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein CTD PMID:15061398 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Mlxipl MLX interacting protein-like decreases expression
multiple interactions
ISO Cetirizine results in decreased expression of MLXIPL mRNA
APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]
CTD PMID:24852568 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA CTD PMID:25020133 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA CTD PMID:25020133 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          cetirizine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  benzenoid aromatic compound 17968
                                    benzenes 17830
                                      chlorobenzenes 14817
                                        monochlorobenzenes 11624
                                          cetirizine 14
paths to the root