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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:biphenyl-4-ol
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Accession:CHEBI:34422 term browser browse the term
Definition:A member of the class of hydroxybiphenyls that is biphenyl carrying a hydroxy group at position 4.
Synonyms:exact_synonym: [1,1'-biphenyl]-4-ol
 related_synonym: 4-Hydroxybiphenyl;   4-Phenylphenol;   4-biphenylol;   4-diphenylol;   4-hydroxydiphenyl;   Formula=C12H10O;   InChI=1S/C12H10O/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13H;   InChIKey=YXVFYQXJAXKLAK-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(C2=CC=CC=C2)=C1)O;   p-biphenylol;   p-hydroxybiphenyl;   p-hydroxydiphenyl;   p-phenylphenol;   para-hydroxydiphenyl;   para-phenylphenol
 xref: CAS:92-69-3;   KEGG:C14224
 xref_mesh: MESH:C019046
 xref: PMID:23491025;   PMID:24519828;   Reaxys:1907452


show annotations for term's descendants           Sort by:
biphenyl-4-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 4-phenylphenol binds to AR protein
4-phenylphenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]		 CTD PMID:14565775 PMID:16916032 PMID:31836225 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression		 ISO 4-phenylphenol results in increased activity of CYP19A1 protein
4-phenylphenol results in increased expression of CYP19A1 mRNA		 CTD PMID:30817981 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
affects binding
increases activity
multiple interactions		 ISO
EXP		 4-phenylphenol results in increased expression of ESR1 mRNA
4-phenylphenol binds to ESR1 protein
4-phenylphenol results in increased activity of ESR1 protein
4-phenylphenol binds to and results in increased activity of ESR1 protein		 CTD PMID:12737316 PMID:12753421 PMID:18028983 PMID:31836225 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression
multiple interactions
affects binding		 ISO 4-phenylphenol results in increased expression of ESR2 mRNA
4-phenylphenol binds to and results in increased activity of ESR2 protein
4-phenylphenol binds to ESR2 protein		 CTD PMID:12737316 PMID:31836225 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 4-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 4-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pgr progesterone receptor increases expression ISO 4-phenylphenol results in increased expression of PGR protein CTD PMID:12753421 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 4-phenylphenol binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 4-phenylphenol results in increased expression of TFF1 protein CTD PMID:12753421 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-phenylphenol CTD PMID:8302279 PMID:11836149 PMID:12153725 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 4-phenylphenol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      molecular entity 19806
        polyatomic entity 19764
          molecule 19670
            cyclic compound 19486
              ring assembly 9171
                biphenyls 6245
                  hydroxybiphenyls 27
                    biphenyl-4-ol 11
                      2,6-dichloro-4'-biphenylol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  benzenoid aromatic compound 17968
                                    biphenyls 6245
                                      hydroxybiphenyls 27
                                        biphenyl-4-ol 11
                                          2,6-dichloro-4'-biphenylol 0
paths to the root