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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxybiphenyls
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Accession:CHEBI:24681 term browser browse the term
Definition:Any member of the class of biphenyls that has one or more hydroxy groups attached to the benzenoid ring system.

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altenusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha decreases activity ISO altenusin results in decreased activity of TOP2A protein CTD PMID:27682608 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
biphenyl-2,2'-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 2,2'-biphenol inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 2,2'-biphenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2] CTD PMID:19528508 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
biphenyl-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions		 ISO 2-phenylphenol results in decreased activity of AR protein
2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]		 CTD PMID:15064155 PMID:18294747 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-phenylphenol results in increased expression of CYP1A1 mRNA CTD PMID:23665931 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 2-phenylphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
increases expression		 ISO 2-phenylphenol results in decreased expression of ESR1 mRNA
2-phenylphenol binds to ESR1 protein
2-phenylphenol results in increased expression of ESR1 mRNA		 CTD PMID:12598185 PMID:12737316 PMID:12822488 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 2-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 affects binding ISO 2-phenylphenol binds to FLT1 protein CTD PMID:32278787 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] CTD PMID:10334203 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO 2-phenylphenol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-phenylphenol results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pgr progesterone receptor increases expression ISO 2-phenylphenol results in increased expression of PGR mRNA CTD PMID:12822488 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 2-phenylphenol results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Serpinb5 serpin family B member 5 affects binding ISO 2-phenylphenol binds to SERPINB5 protein CTD PMID:32278787 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2-phenylphenol binds to THRB protein CTD PMID:32278787 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-phenylphenol CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720 		JBrowse link
G Vdr vitamin D receptor affects binding ISO 2-phenylphenol binds to VDR protein CTD PMID:32278787 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 2-phenylphenol results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
biphenyl-3-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 3-hydroxybiphenyl CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720 		JBrowse link
biphenyl-4,4'-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding ISO 4,4'-dihydroxybiphenyl binds to AR protein CTD PMID:12161000 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 4,4'-dihydroxybiphenyl binds to ESR1 protein CTD PMID:12161000 PMID:12753421 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [4,4'-dihydroxybiphenyl co-treated with Lipopolysaccharides] results in increased expression of PTGS2 CTD PMID:19528508 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
biphenyl-4-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 4-phenylphenol binds to AR protein
4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]		 CTD PMID:14565775 PMID:16916032 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression		 ISO 4-phenylphenol results in increased activity of CYP19A1 protein
4-phenylphenol results in increased expression of CYP19A1 mRNA		 CTD PMID:30817981 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
affects binding
increases activity		 ISO
EXP		 4-phenylphenol results in increased expression of ESR1 mRNA
4-phenylphenol binds to ESR1 protein
4-phenylphenol results in increased activity of ESR1 protein		 CTD PMID:12737316 PMID:12753421 PMID:18028983 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 4-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 4-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Pgr progesterone receptor increases expression ISO 4-phenylphenol results in increased expression of PGR protein CTD PMID:12753421 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 4-phenylphenol results in increased expression of TFF1 protein CTD PMID:12753421 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 4-phenylphenol CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-phenylphenol CTD PMID:8302279 PMID:11836149 PMID:12153725 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    chemical entity 19840
      molecular entity 19838
        polyatomic entity 19754
          molecule 19586
            cyclic compound 19402
              ring assembly 7217
                biphenyls 6001
                  hydroxybiphenyls 26
                    2',3',4',5'-tetrachlorobiphenyl-3-ol 0
                    2',3-dihydroxy-5-methoxybiphenyl 0
                    2',5'-dichlorobiphenyl-3-ol 0
                    2',6'-dichlorobiphenyl-2,3-diol 0
                    2'-chlorobiphenyl-2,3-diol 0
                    2'-hydroxybiphenyl-2-sulfinic acid 0
                    2,6-dichloro-4'-biphenylol 0
                    2-chloro-1,1'-biphenyl-4,4'-diol 0
                    3,3',5,5'-tetrachlorobiphenyl-4,4'-diol 0
                    4'-chlorobiphenyl-2,3-diol + 0
                    4-hydroxy-2',3,5,5'-tetrachlorobiphenyl 0
                    4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl 0
                    4-methoxymagnaldehyde B 0
                    5,6,6'-trihydroxy-5'-methoxy[biphenyl]-3,3'-dicarboxylic acid 0
                    Randainol 0
                    altenusin 1
                    bialamicol 0
                    biphenyl-2,2',3,3'-tetraol 0
                    biphenyl-2,2',3-triol 0
                    biphenyl-2,2'-diol 2
                    biphenyl-2,3-diol + 0
                    biphenyl-2-ol 22
                    biphenyl-3-ol + 1
                    biphenyl-4,4'-diol + 3
                    biphenyl-4-ol + 9
                    ethyl 2-[5-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl]pentanoate 0
                    hydroxybiphenyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic molecule 19555
                              organic cyclic compound 19364
                                carbocyclic compound 18278
                                  benzenoid aromatic compound 17322
                                    biphenyls 6001
                                      hydroxybiphenyls 26
                                        2',3',4',5'-tetrachlorobiphenyl-3-ol 0
                                        2',3-dihydroxy-5-methoxybiphenyl 0
                                        2',5'-dichlorobiphenyl-3-ol 0
                                        2',6'-dichlorobiphenyl-2,3-diol 0
                                        2'-chlorobiphenyl-2,3-diol 0
                                        2'-hydroxybiphenyl-2-sulfinic acid 0
                                        2,6-dichloro-4'-biphenylol 0
                                        2-chloro-1,1'-biphenyl-4,4'-diol 0
                                        3,3',5,5'-tetrachlorobiphenyl-4,4'-diol 0
                                        4'-chlorobiphenyl-2,3-diol + 0
                                        4-hydroxy-2',3,5,5'-tetrachlorobiphenyl 0
                                        4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl 0
                                        4-methoxymagnaldehyde B 0
                                        5,6,6'-trihydroxy-5'-methoxy[biphenyl]-3,3'-dicarboxylic acid 0
                                        Randainol 0
                                        altenusin 1
                                        bialamicol 0
                                        biphenyl-2,2',3,3'-tetraol 0
                                        biphenyl-2,2',3-triol 0
                                        biphenyl-2,2'-diol 2
                                        biphenyl-2,3-diol + 0
                                        biphenyl-2-ol 22
                                        biphenyl-3-ol + 1
                                        biphenyl-4,4'-diol + 3
                                        biphenyl-4-ol + 9
                                        ethyl 2-[5-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl]pentanoate 0
                                        hydroxybiphenyl 0
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