CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxybiphenyls
Accession: CHEBI:24681
browse the term
Definition: Any member of the class of biphenyls that has one or more hydroxy groups attached to the benzenoid ring system.
G
Top2a
DNA topoisomerase II alpha
decreases activity
ISO
altenusin results in decreased activity of TOP2A protein
CTD
PMID:27682608
NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
G
Ar
androgen receptor
multiple interactions
ISO
2,2'-biphenol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
2,2'-biphenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]
CTD
PMID:19528508
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Ar
androgen receptor
decreases activity multiple interactions
ISO
2-phenylphenol results in decreased activity of AR protein 2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]
CTD
PMID:15064155 PMID:18294747 PMID:21310686
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]
CTD
PMID:10334203
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
2-phenylphenol results in increased expression of CYP1A1 mRNA
CTD
PMID:23665931
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects binding
ISO
2-phenylphenol binds to CYP1A2 protein
CTD
PMID:32278787
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Esr1
estrogen receptor 1
decreases expression affects binding increases expression
ISO
2-phenylphenol results in decreased expression of ESR1 mRNA 2-phenylphenol binds to ESR1 protein 2-phenylphenol results in increased expression of ESR1 mRNA
CTD
PMID:12598185 PMID:12737316 PMID:12822488
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Esr2
estrogen receptor 2
increases expression
ISO
2-phenylphenol results in increased expression of ESR2 mRNA
CTD
PMID:12737316
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
G
Flt1
Fms related receptor tyrosine kinase 1
affects binding
ISO
2-phenylphenol binds to FLT1 protein
CTD
PMID:32278787
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
G
Hexb
hexosaminidase subunit beta
multiple interactions
EXP
zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein]
CTD
PMID:15272608
NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]
CTD
PMID:10334203
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
G
Mmp9
matrix metallopeptidase 9
affects binding
ISO
2-phenylphenol binds to MMP9 protein
CTD
PMID:32278787
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
2-phenylphenol binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
2-phenylphenol results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
G
Orm1
orosomucoid 1
increases expression
ISO
2-phenylphenol results in increased expression of ORM1 protein
CTD
PMID:20025956
NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
G
Pgr
progesterone receptor
increases expression
ISO
2-phenylphenol results in increased expression of PGR mRNA
CTD
PMID:12822488
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
G
Phex
phosphate regulating endopeptidase homolog, X-linked
increases expression
ISO
2-phenylphenol results in increased expression of PHEX protein
CTD
PMID:20025956
NCBI chr X:40,460,047...40,717,982
Ensembl chr X:40,460,047...40,717,982
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2
CTD
PMID:26359731
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Serpinb5
serpin family B member 5
affects binding
ISO
2-phenylphenol binds to SERPINB5 protein
CTD
PMID:32278787
NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
G
Thrb
thyroid hormone receptor beta
affects binding
ISO
2-phenylphenol binds to THRB protein
CTD
PMID:32278787
NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
G
Tp53
tumor protein p53
multiple interactions
ISO
[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]
CTD
PMID:10334203
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of 2-phenylphenol
CTD
PMID:7574722
NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
G
Vdr
vitamin D receptor
affects binding
ISO
2-phenylphenol binds to VDR protein
CTD
PMID:32278787
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
G
Vegfa
vascular endothelial growth factor A
increases expression
ISO
2-phenylphenol results in increased expression of VEGFA protein
CTD
PMID:20025956
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of 3-hydroxybiphenyl
CTD
PMID:7574722
NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
G
Ar
androgen receptor
affects binding
ISO
4,4'-dihydroxybiphenyl binds to AR protein
CTD
PMID:12161000
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Esr1
estrogen receptor 1
affects binding
ISO
4,4'-dihydroxybiphenyl binds to ESR1 protein
CTD
PMID:12161000 PMID:12753421
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[4,4'-dihydroxybiphenyl co-treated with Lipopolysaccharides] results in increased expression of PTGS2
CTD
PMID:19528508
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Ar
androgen receptor
affects binding multiple interactions
EXP ISO
4-phenylphenol binds to AR protein 4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:14565775 PMID:16916032
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases activity increases expression
ISO
4-phenylphenol results in increased activity of CYP19A1 protein 4-phenylphenol results in increased expression of CYP19A1 mRNA
CTD
PMID:30817981
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
G
Esr1
estrogen receptor 1
increases expression affects binding increases activity
ISO EXP
4-phenylphenol results in increased expression of ESR1 mRNA 4-phenylphenol binds to ESR1 protein 4-phenylphenol results in increased activity of ESR1 protein
CTD
PMID:12737316 PMID:12753421 PMID:18028983
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Esr2
estrogen receptor 2
increases expression
ISO
4-phenylphenol results in increased expression of ESR2 mRNA
CTD
PMID:12737316
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
4-phenylphenol results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
G
Pgr
progesterone receptor
increases expression
ISO
4-phenylphenol results in increased expression of PGR protein
CTD
PMID:12753421
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
G
Tff1
trefoil factor 1
increases expression
ISO
4-phenylphenol results in increased expression of TFF1 protein
CTD
PMID:12753421
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of 4-phenylphenol
CTD
PMID:7574722
NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
G
Ugt2b17
UDP glucuronosyltransferase family 2 member B17
increases glucuronidation
EXP
UGT2B1 protein results in increased glucuronidation of 4-phenylphenol
CTD
PMID:8302279 PMID:11836149 PMID:12153725
NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19840
chemical entity
19840
molecular entity
19838
polyatomic entity
19754
molecule
19586
cyclic compound
19402
ring assembly
7217
biphenyls
6001
hydroxybiphenyls
26
2',3',4',5'-tetrachlorobiphenyl-3-ol
0
2',3-dihydroxy-5-methoxybiphenyl
0
2',5'-dichlorobiphenyl-3-ol
0
2',6'-dichlorobiphenyl-2,3-diol
0
2'-chlorobiphenyl-2,3-diol
0
2'-hydroxybiphenyl-2-sulfinic acid
0
2,6-dichloro-4'-biphenylol
0
2-chloro-1,1'-biphenyl-4,4'-diol
0
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
0
4'-chlorobiphenyl-2,3-diol +
0
4-hydroxy-2',3,5,5'-tetrachlorobiphenyl
0
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
0
4-methoxymagnaldehyde B
0
5,6,6'-trihydroxy-5'-methoxy[biphenyl]-3,3'-dicarboxylic acid
0
Randainol
0
altenusin
1
bialamicol
0
biphenyl-2,2',3,3'-tetraol
0
biphenyl-2,2',3-triol
0
biphenyl-2,2'-diol
2
biphenyl-2,3-diol +
0
biphenyl-2-ol
22
biphenyl-3-ol +
1
biphenyl-4,4'-diol +
3
biphenyl-4-ol +
9
ethyl 2-[5-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl]pentanoate
0
hydroxybiphenyl
0
Path 2
CHEBI ontology
19840
subatomic particle
19838
composite particle
19838
hadron
19838
baryon
19838
nucleon
19838
atomic nucleus
19838
atom
19838
main group element atom
19730
p-block element atom
19730
carbon group element atom
19635
carbon atom
19624
organic molecular entity
19624
organic molecule
19555
organic cyclic compound
19364
carbocyclic compound
18278
benzenoid aromatic compound
17322
biphenyls
6001
hydroxybiphenyls
26
2',3',4',5'-tetrachlorobiphenyl-3-ol
0
2',3-dihydroxy-5-methoxybiphenyl
0
2',5'-dichlorobiphenyl-3-ol
0
2',6'-dichlorobiphenyl-2,3-diol
0
2'-chlorobiphenyl-2,3-diol
0
2'-hydroxybiphenyl-2-sulfinic acid
0
2,6-dichloro-4'-biphenylol
0
2-chloro-1,1'-biphenyl-4,4'-diol
0
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
0
4'-chlorobiphenyl-2,3-diol +
0
4-hydroxy-2',3,5,5'-tetrachlorobiphenyl
0
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
0
4-methoxymagnaldehyde B
0
5,6,6'-trihydroxy-5'-methoxy[biphenyl]-3,3'-dicarboxylic acid
0
Randainol
0
altenusin
1
bialamicol
0
biphenyl-2,2',3,3'-tetraol
0
biphenyl-2,2',3-triol
0
biphenyl-2,2'-diol
2
biphenyl-2,3-diol +
0
biphenyl-2-ol
22
biphenyl-3-ol +
1
biphenyl-4,4'-diol +
3
biphenyl-4-ol +
9
ethyl 2-[5-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl]pentanoate
0
hydroxybiphenyl
0