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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acarbose
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Accession:CHEBI:2376 term browser browse the term
Definition:A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.
Synonyms:exact_synonym: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
 related_synonym: Formula=C25H43NO18;   Glucobay;   InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12+,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1;   InChIKey=XUFXOAAUWZOOIT-UGEKTDRHSA-N;   Precose;   SMILES=C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O;   acarbosa;   acarbosum
 alt_id: CHEBI:40513
 xref: CAS:56180-94-0;   Chemspider:38116;   DrugBank:DB00284;   Drug_Central:39;   HMDB:HMDB0014429;   KEGG:C06802;   KEGG:D00216;   KNApSAcK:C00016021;   LINCS:LSM-4345
 xref_mesh: MESH:D020909
 xref: PMID:11937512;   PMID:18248270;   PMID:24245565;   PMID:25044702;   PMID:8893066;   PMID:9805641;   Patent:DE2347782;   Patent:US4062950;   Wikipedia:Acarbose
 cyclic_relationship: is_conjugate_base_of CHEBI:84363


show annotations for term's descendants           Sort by:
acarbose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Acarbose results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Acarbose results in increased expression of ADIPOQ protein CTD PMID:18290871 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein] CTD PMID:17133782 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP Acarbose results in decreased expression of CYP2E1 mRNA CTD PMID:14975757 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Acarbose results in decreased expression of FASN mRNA; Acarbose results in decreased expression of FASN protein CTD PMID:8101498 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Ins1 insulin 1 increases response to substance
decreases secretion
decreases expression
increases secretion
multiple interactions		 EXP Acarbose results in increased susceptibility to INS1 protein
Acarbose results in decreased secretion of INS1 protein
Acarbose results in decreased expression of INS1 protein
Acarbose results in increased secretion of INS1 protein
Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased expression of INS1 protein]		 CTD PMID:1767839 PMID:8101498 PMID:9313782 PMID:18290871 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lep leptin decreases expression EXP Acarbose results in decreased expression of LEP protein CTD PMID:18290871 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mgam maltase-glucoamylase decreases activity ISO Acarbose results in decreased activity of MGAM protein CTD PMID:17585022 PMID:20349118 NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715 		JBrowse link
G Npy neuropeptide Y decreases expression EXP Acarbose results in decreased expression of NPY protein CTD PMID:18290871 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects response to substance ISO PPARGC1A protein polymorphism affects the susceptibility to Acarbose CTD PMID:15592662 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Acarbose results in increased expression of SLC2A1 protein CTD PMID:11779583 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Acarbose results in increased expression of SLC2A4 mRNA; Acarbose results in increased expression of SLC2A4 protein CTD PMID:1767839 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sqstm1 sequestosome 1 affects response to substance ISO SQSTM1 affects the susceptibility to Acarbose CTD PMID:19207582 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 Acarbose results in decreased expression of TNF mRNA
Acarbose results in decreased expression of TNF mRNA; Acarbose results in decreased expression of TNF protein
Acarbose inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]		 CTD PMID:12717270 PMID:14975757 PMID:20703014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pharmaceutical 19502
          drug 19502
            hypoglycemic agent 4207
              acarbose 14
                acarbose 7(IV)-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      oligosaccharide 619
                                        tetrasaccharide 17
                                          tetrasaccharide derivative 15
                                            acarbose 14
                                              acarbose 7(IV)-phosphate 0
paths to the root