CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: acarbose
Accession: CHEBI:2376
browse the term
Definition: A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose.
Synonyms: exact_synonym: 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose
related_synonym: Formula=C25H43NO18; Glucobay; InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12+,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1; InChIKey=XUFXOAAUWZOOIT-UGEKTDRHSA-N; Precose; SMILES=C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O; acarbosa; acarbosum
alt_id: CHEBI:40513
xref: CAS:56180-94-0; Chemspider:38116; DrugBank:DB00284; Drug_Central:39; HMDB:HMDB0014429; KEGG:C06802; KEGG:D00216; KNApSAcK:C00016021; LINCS:LSM-4345
xref_mesh: MESH:D020909
xref: PMID:11937512; PMID:18248270; PMID:24245565; PMID:25044702; PMID:8893066; PMID:9805641; Patent:DE2347782; Patent:US4062950; Wikipedia:Acarbose
cyclic_relationship: is_conjugate_base_of CHEBI:84363
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Acarbose results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
EXP
Acarbose results in increased expression of ADIPOQ protein
CTD
PMID:18290871
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
EXP
Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein]
CTD
PMID:17133782
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
EXP
Acarbose results in decreased expression of CYP2E1 mRNA
CTD
PMID:14975757
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Fasn
fatty acid synthase
decreases expression
EXP
Acarbose results in decreased expression of FASN mRNA; Acarbose results in decreased expression of FASN protein
CTD
PMID:8101498
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Ins1
insulin 1
increases response to substance decreases secretion decreases expression increases secretion multiple interactions
EXP
Acarbose results in increased susceptibility to INS1 protein Acarbose results in decreased secretion of INS1 protein Acarbose results in decreased expression of INS1 protein Acarbose results in increased secretion of INS1 protein Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased expression of INS1 protein]
CTD
PMID:1767839 PMID:8101498 PMID:9313782 PMID:18290871
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Lep
leptin
decreases expression
EXP
Acarbose results in decreased expression of LEP protein
CTD
PMID:18290871
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mgam
maltase-glucoamylase
decreases activity
ISO
Acarbose results in decreased activity of MGAM protein
CTD
PMID:17585022 PMID:20349118
NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715
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Npy
neuropeptide Y
decreases expression
EXP
Acarbose results in decreased expression of NPY protein
CTD
PMID:18290871
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Ppargc1a
PPARG coactivator 1 alpha
affects response to substance
ISO
PPARGC1A protein polymorphism affects the susceptibility to Acarbose
CTD
PMID:15592662
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Slc2a1
solute carrier family 2 member 1
increases expression
EXP
Acarbose results in increased expression of SLC2A1 protein
CTD
PMID:11779583
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4
solute carrier family 2 member 4
increases expression
EXP
Acarbose results in increased expression of SLC2A4 mRNA; Acarbose results in increased expression of SLC2A4 protein
CTD
PMID:1767839
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Sqstm1
sequestosome 1
affects response to substance
ISO
SQSTM1 affects the susceptibility to Acarbose
CTD
PMID:19207582
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO EXP
Acarbose results in decreased expression of TNF mRNA Acarbose results in decreased expression of TNF mRNA; Acarbose results in decreased expression of TNF protein Acarbose inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD
PMID:12717270 PMID:14975757 PMID:20703014
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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