Map2k1 (mitogen activated protein kinase kinase 1) - Rat Genome Database

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Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
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Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
RGD ID: 70495
Description: Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including positive regulation of metabolic process; regulation of intracellular signal transduction; and regulation of muscle contraction. Acts upstream of or within MAPK cascade; insulin receptor signaling pathway; and positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,578,747 - 73,650,184 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,578,752 - 73,650,184 (-)EnsemblGRCr8
mRatBN7.2864,683,449 - 64,754,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,683,449 - 64,755,147 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx870,198,296 - 70,269,639 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,470,887 - 68,542,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,340,874 - 66,412,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera864,090,188 - 64,161,314 (-)NCBICelera
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(20R)-protopanaxadiol  (ISO)
(Z)-PUGNAc  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,5-dimethylcelecoxib  (ISO)
2,6-dinitrotoluene  (EXP)
2-aminobiphenyl  (ISO)
2-arachidonoylglycerol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amsacrine  (ISO)
anandamide  (EXP)
anethole  (ISO)
anthranilic acid  (ISO)
antimonite  (ISO)
Antrocin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beryllium difluoride  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (EXP)
dabrafenib  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
escitalopram  (EXP)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
heparin  (EXP)
heptachlor  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketamine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PD 0325901  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perifosine  (ISO)
phenylephrine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
prednisone  (ISO)
propiconazole  (ISO)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
purine-6-thiol  (ISO)
pyocyanine  (ISO)
quercetin  (ISO)
quinoline  (ISO)
quinomethionate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SCH772984  (EXP)
serpentine asbestos  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfates  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
toosendanin  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
vanadyl sulfate  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Bergmann glial cell differentiation  (ISO)
cell motility  (ISO)
cellular senescence  (IEA,ISO)
cerebellar cortex formation  (ISO)
epithelial cell proliferation involved in lung morphogenesis  (ISO)
ERBB signaling pathway  (IEA,ISO)
ERBB2-ERBB3 signaling pathway  (IEA,ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
Golgi inheritance  (IMP)
heart development  (ISO)
insulin receptor signaling pathway  (IMP)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intracellular signal transduction  (TAS)
keratinocyte differentiation  (ISO)
labyrinthine layer development  (ISO)
lung morphogenesis  (ISO)
MAPK cascade  (IBA,IEA,IMP,ISO)
melanosome transport  (IDA)
myelination  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of gene expression  (IEA,IGI)
negative regulation of homotypic cell-cell adhesion  (IMP)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IGI,IMP)
neuromuscular junction development  (IEA,ISO)
neuron differentiation  (IBA,IMP,ISO)
neuron projection morphogenesis  (IMP)
placenta blood vessel development  (ISO)
positive regulation of ATP biosynthetic process  (IGI,IMP)
positive regulation of autophagy  (IDA)
positive regulation of axonogenesis  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,IGI,IMP,ISO)
positive regulation of GTPase activity  (IMP)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of muscle contraction  (IGI,IMP)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (IMP)
positive regulation of transcription elongation by RNA polymerase II  (IMP)
protein phosphorylation  (IDA,ISO,TAS)
regulation of axon regeneration  (ISO)
regulation of early endosome to late endosome transport  (IEA,TAS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of Golgi inheritance  (IEA,TAS)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (EXP,IDA)
regulation of stress-activated MAPK cascade  (IEA,TAS)
regulation of vascular associated smooth muscle contraction  (IMP)
response to axon injury  (IMP)
response to glucocorticoid  (IDA)
response to oxidative stress  (IDA)
Schwann cell development  (IEA,ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)
triglyceride homeostasis  (IDA)
vesicle transport along microtubule  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
influenza A pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA,ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway   (IEA)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IMP,TAS)
thyroid cancer pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis. Acharya U, etal., Cell. 1998 Jan 23;92(2):183-92.
2. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Alessandrini A, etal., Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12866-9.
3. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Blasco RB, etal., Cancer Cell. 2011 May 17;19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.
4. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras. Brassard DL, etal., Exp Cell Res. 2002 Feb 15;273(2):138-46.
5. A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Catling AD, etal., Mol Cell Biol. 1995 Oct;15(10):5214-25.
6. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
7. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24.
8. RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis. Colanzi A, etal., J Cell Biol. 2003 Apr 14;161(1):27-32.
9. Regulation of bidirectional melanosome transport by organelle bound MAP kinase. Deacon SW, etal., Curr Biol. 2005 Mar 8;15(5):459-63.
10. Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator. Doring F, etal., Gene 1993 Sep 15;131(2):303-4.
11. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Duan RD, etal., Am J Physiol. 1995 Jun;268(6 Pt 1):G1060-5.
12. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100.
13. Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. Flood DG, etal., J Comp Neurol. 1998 Aug 31;398(3):373-92.
14. Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells. Fujita T, etal., Mol Cell Biol. 2008 Mar;28(5):1630-43. Epub 2007 Dec 17.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Giroux S, etal., Curr Biol 1999 Apr 8;9(7):369-72.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Gong X, etal., Invest Ophthalmol Vis Sci. 2001 Mar;42(3):539-48.
19. Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis. Guan Z, etal., Mol Med Rep. 2017 Oct;16(4):4784-4790. doi: 10.3892/mmr.2017.7213. Epub 2017 Aug 10.
20. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Halbrook CJ, etal., Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):99-118. doi: 10.1016/j.jcmgh.2016.09.009.
21. Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Huang D, etal., Cancer Res. 2008 Jan 1;68(1):81-8.
22. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
23. Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells. Kim BW and Son H, Exp Mol Med. 2006 Dec 31;38(6):732-8.
24. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
25. Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen. Kupryjanczyk J, etal., Br J Cancer. 2003 Mar 24;88(6):848-54.
26. Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways. Kwintkiewicz J, etal., Biol Reprod. 2006 Jun;74(6):1034-40. Epub 2006 Feb 15.
27. Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries. Lagaud GJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):523-7.
28. Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway. MacInnis BL and Campenot RB, Mol Cell Neurosci. 2005 Mar;28(3):430-9.
29. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. Marinovic AC, etal., J Biol Chem 2002 May 10;277(19):16673-81.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. Mizukami Y, etal., J Biol Chem. 2004 Nov 26;279(48):50120-31. Epub 2004 Sep 30.
32. Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf. Moodie SA, etal., Mol Cell Biol. 1994 Nov;14(11):7153-62.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Oka H, etal., Cancer Res. 1995 Sep 15;55(18):4182-7.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Isolation of two members of the rat MAP kinase kinase gene family. Otsu M, etal., FEBS Lett 1993 Apr 12;320(3):246-50.
37. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. MEK/ERK regulates adherens junctions and migration through Rac1. Ray RM, etal., Cell Motil Cytoskeleton. 2007 Mar;64(3):143-56.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo. Robinson JP, etal., Oncogene. 2011 Mar 17;30(11):1341-50. doi: 10.1038/onc.2010.513. Epub 2010 Nov 8.
46. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Rodriguez-Viciana P, etal., Science. 2006 Mar 3;311(5765):1287-90. Epub 2006 Jan 26.
47. Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. Salh B, etal., Anticancer Res. 1999 Jan-Feb;19(1B):731-40.
48. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
49. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
50. The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells. Schipper HM, etal., Neuroscience. 1999;93(2):585-95.
51. PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. Slack-Davis JK, etal., J Cell Biol. 2003 Jul 21;162(2):281-91.
52. Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells. Su F, etal., J Cancer Res Clin Oncol. 2009 Dec;135(12):1655-63. doi: 10.1007/s00432-009-0612-6. Epub 2009 Jun 10.
53. Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma. Suthiphongchai T, etal., Oncol Res. 2003;13(5):253-9.
54. ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain. Suzuki T, etal., Neurosci Res. 1995 Jun;22(3):277-85.
55. A subdomain of MEKK1 that is critical for binding to MKK4. Tu Z, etal., Cell Signal. 2003 Jan;15(1):65-77.
56. Selective gene activation by spatial segregation of insulin receptor B signaling. Uhles S, etal., FASEB J. 2007 May;21(7):1609-21. doi: 10.1096/fj.06-7589com. Epub 2007 Jan 30.
57. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
58. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. Voisin L, etal., BMC Cancer. 2008 Nov 17;8:337. doi: 10.1186/1471-2407-8-337.
59. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
60. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
61. Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. Wu J, etal., Biochem J 1992 Aug 1;285 ( Pt 3):701-5.
62. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Wu J, etal., Mol Cell Biol 1993 Aug;13(8):4539-48.
63. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Wu J, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):173-7.
64. Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy. Xiao Y, etal., Diabetes. 2016 Feb;65(2):393-405. doi: 10.2337/db15-1024. Epub 2015 Nov 18.
65. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. Xu J, etal., J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.
66. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Xu S, etal., Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6808-12.
67. The ERK signaling cascade--views from different subcellular compartments. Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
68. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Zhu JJ, etal., Cell. 2002 Aug 23;110(4):443-55.
Additional References at PubMed
PMID:8026469   PMID:8388392   PMID:8889548   PMID:9765203   PMID:10407019   PMID:10409742   PMID:10644344   PMID:11841548   PMID:12477932   PMID:12624112   PMID:14963006   PMID:15145949  
PMID:15155804   PMID:15469737   PMID:15782137   PMID:15896720   PMID:16737746   PMID:16908534   PMID:17498664   PMID:18006605   PMID:18270979   PMID:18952847   PMID:19047410   PMID:19249349  
PMID:19340459   PMID:19447520   PMID:19453943   PMID:19462441   PMID:20001965   PMID:20942268   PMID:21263381   PMID:21777515   PMID:22294037   PMID:22572157   PMID:23096919   PMID:23376485  
PMID:23626836   PMID:24126801   PMID:24375836   PMID:24431450   PMID:24610459   PMID:24733831   PMID:25100655   PMID:26272725   PMID:26514923   PMID:28166211   PMID:28975447   PMID:29433126  
PMID:29476059   PMID:30053369   PMID:30206251   PMID:30876692   PMID:31505169   PMID:32357304  


Genomics

Comparative Map Data
Map2k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,578,747 - 73,650,184 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,578,752 - 73,650,184 (-)EnsemblGRCr8
mRatBN7.2864,683,449 - 64,754,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,683,449 - 64,755,147 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx870,198,296 - 70,269,639 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,470,887 - 68,542,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,340,874 - 66,412,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera864,090,188 - 64,161,314 (-)NCBICelera
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Cytogenetic Map8q24NCBI
MAP2K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381566,386,912 - 66,491,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1566,386,825 - 66,491,656 (+)Ensemblhg38GRCh38
GRCh371566,679,250 - 66,783,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,466,679 - 64,570,936 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341564,466,678 - 64,570,935NCBI
Celera1543,568,908 - 43,673,089 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,515,493 - 43,620,002 (+)NCBIHuRef
CHM1_11566,797,173 - 66,901,898 (+)NCBICHM1_1
T2T-CHM13v2.01564,208,363 - 64,313,019 (+)NCBIT2T-CHM13v2.0
Map2k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,093,066 - 64,160,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,093,052 - 64,160,913 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38964,185,769 - 64,253,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,185,770 - 64,253,631 (-)Ensemblmm10GRCm38
MGSCv37964,033,600 - 64,101,412 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36963,983,794 - 64,051,338 (-)NCBIMGSCv36mm8
Celera961,410,935 - 61,478,604 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.55NCBI
Map2k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,181,851 - 9,239,648 (-)Ensembl
ChiLan1.0NW_0049554509,181,851 - 9,205,277 (-)NCBIChiLan1.0ChiLan1.0
MAP2K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,642,226 - 55,744,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,814,985 - 59,916,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01545,337,117 - 45,438,826 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,613,988 - 63,714,928 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,613,961 - 63,714,161 (+)EnsemblpanPan2panpan1.1
MAP2K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,683,192 - 30,760,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,683,107 - 30,760,479 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3030,613,296 - 30,690,593 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03030,879,701 - 30,957,083 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,878,118 - 30,957,083 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,809,219 - 30,886,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,868,842 - 30,945,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,110,222 - 31,187,514 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map2k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,704,376 - 108,780,234 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,589,161 - 26,628,302 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,589,251 - 26,628,302 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,381,845 - 164,471,226 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11164,381,892 - 164,469,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,187,631 - 182,196,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,059,122 - 17,168,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,060,054 - 17,168,782 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048124,281,623 - 124,391,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,222,365 - 6,285,531 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247816,222,365 - 6,285,398 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Map2k1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1858,490,586 - 58,560,952 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map2k1
338 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000013933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat

Markers in Region
RH140096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,693,122 - 64,693,339 (+)MAPPERmRatBN7.2
Rnor_6.0869,143,892 - 69,144,108NCBIRnor6.0
Rnor_5.0868,850,128 - 68,850,344UniSTSRnor5.0
RGSC_v3.4868,388,746 - 68,388,962UniSTSRGSC3.4
Celera864,099,862 - 64,100,078UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH143905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,754,956 - 64,755,187 (+)MAPPERmRatBN7.2
Rnor_6.0869,722,309 - 69,722,539NCBIRnor6.0
Rnor_5.0869,431,673 - 69,431,903UniSTSRnor5.0
Celera864,161,371 - 64,161,600UniSTS
RH 3.4 Map8808.2UniSTS
Cytogenetic Map8q24UniSTS
RH137806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,729,870 - 64,730,025 (+)MAPPERmRatBN7.2
Rnor_6.0869,179,742 - 69,179,896NCBIRnor6.0
Rnor_5.0868,886,035 - 68,886,189UniSTSRnor5.0
RGSC_v3.4868,426,345 - 68,426,499UniSTSRGSC3.4
Celera864,136,284 - 64,136,438UniSTS
RH 3.4 Map8806.9UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013933   ⟹   ENSRNOP00000013933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,578,752 - 73,611,016 (-)Ensembl
mRatBN7.2 Ensembl864,683,490 - 64,755,147 (-)Ensembl
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097110   ⟹   ENSRNOP00000092766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,579,649 - 73,650,184 (-)Ensembl
mRatBN7.2 Ensembl864,684,351 - 64,715,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097536   ⟹   ENSRNOP00000081692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,683,449 - 64,715,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102833   ⟹   ENSRNOP00000086602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,578,752 - 73,637,801 (-)Ensembl
mRatBN7.2 Ensembl864,683,449 - 64,743,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120242   ⟹   ENSRNOP00000084527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,578,752 - 73,650,184 (-)Ensembl
mRatBN7.2 Ensembl864,683,449 - 64,715,723 (-)Ensembl
RefSeq Acc Id: NM_031643   ⟹   NP_113831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,578,747 - 73,650,184 (-)NCBI
mRatBN7.2864,683,449 - 64,754,900 (-)NCBI
Rnor_6.0869,134,218 - 69,722,252 (-)NCBI
Rnor_5.0868,840,454 - 68,877,679 (-)NCBI
RGSC_v3.4868,379,074 - 68,451,554 (-)RGD
Celera864,090,188 - 64,161,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080739   ⟹   XP_038936667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,578,747 - 73,639,637 (-)NCBI
mRatBN7.2864,683,449 - 64,742,332 (-)NCBI
RefSeq Acc Id: NP_113831   ⟸   NM_031643
- UniProtKB: Q5EBD5 (UniProtKB/Swiss-Prot),   Q01986 (UniProtKB/Swiss-Prot),   A6J5B8 (UniProtKB/TrEMBL),   A0A0H2UHI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013933   ⟸   ENSRNOT00000013933
RefSeq Acc Id: XP_038936667   ⟸   XM_039080739
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1J3 (UniProtKB/TrEMBL),   A0A8I5ZT77 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084527   ⟸   ENSRNOT00000120242
Ensembl Acc Id: ENSRNOP00000086602   ⟸   ENSRNOT00000102833
Ensembl Acc Id: ENSRNOP00000092766   ⟸   ENSRNOT00000097110
Ensembl Acc Id: ENSRNOP00000081692   ⟸   ENSRNOT00000097536
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01986-F1-model_v2 AlphaFold Q01986 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70495 AgrOrtholog
BioCyc Gene G2FUF-30104 BioCyc
Ensembl Genes ENSRNOG00000010176 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000102833 ENTREZGENE
  ENSRNOT00000120242 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7382030 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase_kinase UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:170851 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108573 IMAGE-MGC_LOAD
NCBI Gene 170851 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAP2K1 RGD
PhenoGen Map2k1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010176 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0H2UHI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT77 ENTREZGENE
  A0A8I6A1J3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEA6_RAT UniProtKB/TrEMBL
  A6J5B8 ENTREZGENE, UniProtKB/TrEMBL
  MP2K1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBD5 ENTREZGENE
UniProt Secondary Q5EBD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression high in brain, lung, and liver 70317
gene_expression expression decreases in cardiac ventricles after birth 70317
gene_expression expression decreases in cardiac ventricles after birth; expression high in brain, lung, and liver 70317
gene_function phosphorylates and activates Mapk1 and Mapk3 70317
gene_protein contains 393 amino acids 729191
gene_regulation phosphorylated by Raf; nitric oxide enhances phosphorylation 70317