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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1increases phosphorylationISOMAP2K1 (Homo sapiens)6480464CTDZinc Sulfate results in increased phosphorylation of MAP2K1 proteinPMID:11943669
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTD4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAP2K1 protein]; MRAS mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAP2K1 protein]; Zinc Sulfate results in increased phosphorylation of and results in increased activity of MAP2K1 proteinPMID:10564177 PMID:11943669
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