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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1increases response to substanceEXP 6480464CTDMAP2K1 protein results in increased susceptibility to OxygenPMID:10780954
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTD[Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of MAP2K1 mRNA; [Oxygen co-treated with Ozone] inhibits the reaction [Cannabidiol results in decreased expression of MAP2K1 mRNA]; [Oxygen co-treated with Ozone] results in decreased expression of MAP2K1 mRNA; Cannabidiol inhibits the reaction [[Oxygen co-treated with Ozone] results in decreased expression of MAP2K1 mRNA]PMID:32992648
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