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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1decreases activityISOMAP2K1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of MAP2K1 proteinPMID:11304686
Map2k1decreases phosphorylationISOMap2k1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased phosphorylation of MAP2K1 proteinPMID:28454374
Map2k1decreases phosphorylationISOMAP2K1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased phosphorylation of MAP2K1 proteinPMID:20592496
Map2k1increases expressionISOMAP2K1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MAP2K1 mRNAPMID:22521957
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAP2K1 proteinPMID:20615082
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