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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1multiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNAPMID:18636392
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MAP2K1 mRNA; [Air Pollutants results in increased abundance of Ozone] which affects the expression of MAP2K1 mRNA; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of MAP2K1 mRNA; [Oxygen co-treated with Ozone] inhibits the reaction [Cannabidiol results in decreased expression of MAP2K1 mRNA]; [Oxygen co-treated with Ozone] results in decreased expression of MAP2K1 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA; Cannabidiol inhibits the reaction [[Oxygen co-treated with Ozone] results in decreased expression of MAP2K1 mRNA]PMID:32699268 PMID:32992648 PMID:35430440
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