Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	70495
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Map2k1
Name:	mitogen activated protein kinase kinase 1

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Map2k1	increases activity	ISO	Map2k1 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein	PMID:17693661 PMID:18767048 PMID:8816498
Map2k1	increases phosphorylation	ISO	MAP2K1 (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein	PMID:20479004
Map2k1	multiple interactions	ISO	Map2k1 (Mus musculus)	6480464	CTD	3,5,3',4',5'-pentahydroxy-stilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]; geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]	PMID:17693661 PMID:18767048 PMID:8816498
Map2k1	multiple interactions	ISO	MAP2K1 (Homo sapiens)	6480464	CTD	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; MAP2K1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein]	PMID:11861786 PMID:16945329 PMID:20479004

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