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Gene:
Kras ( Rattus norvegicus )
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Description:member of the Ras family of small GTPase signal transducers; activating mutations result in oncogenic transformation leading to neoplasms in a variety of tissues
Synonyms:Kras2; c-Kirsten-ras proto-oncogene; c-Ki-ras; p21; Kirsten rat sarcoma viral oncogene homologue 2 (active);  (details...)
ArrayIDs:6522947; 6625752; 6711145; rc_AI045340_at; U09793_at; 6257879; 6653666; rc_AA944575_at; GE20854; 1370035_at; 6176595; A_44_P219585; 6223703; 6388622;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: KRAS     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Kras     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusKrasgenome assembly 3.14183114365 - 183140230
  Rat Celera Assembly4166708846 - 166734692
  RGSC genome assembly v3.44182869242 - 182895106
  Cytogenetic4q44
Mus musculusKrasMouse genome assembly build 36.16145165227 - 145198751
  Cytogenetic66 G2
Homo sapiensKRAShuman genome assembly1225249446 - 25295121
  Human genome assembly build 36.21225249447 - 25295121
  Cytogenetic12p12.1
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
NoteReference
GTPase628557
Gene Ontology
protein binding,  LRR domain binding,  GMP binding ...  (details...)
Biological Process
NoteReference
widely known activator of MAPK1/2 signalling cascade628557
Gene Ontology
response to glucocorticoid stimulus,  positive regulation of cell proliferation,  response to mineralocorticoid stimulus ...  (details...)
Cellular Component
Gene Ontology
membrane raft,  plasma membrane,  membrane fraction (details...)
Disease
Ontology
Sarcoma, Experimental,  Colorectal Neoplasms,  Cardiomyopathy, Congestive ...  (details...)
Pathway
NoteReference
active in a signalling cascade involving MAPK1/2628557
Ontology
the extracellular signal-regulated Raf/Mek/Erk signaling pathway,  colorectal cancer pathway,  altered extracellular signal-regulated Raf/Mek/Erk signaling pathway (details...)
Regulation
NoteReference
expression significantly increased by aldosterone628557
Drugs
NoteReference
expression suppressed by sprionolactone, inhibitor of mineralocorticoid receptor (MR)628557
 
 External Links
Databases
DATABASEIDSOURCE
SMART:RASIPI
PROSITE:RASIPI
UNIPARC:UPI0000023446IPI
UNIPARC:UPI000013313BIPI
KEGG Report:rno:24525ENTREZGENE
HomoloGene Group ID:37990ENTREZGENE
Germonline:2981
Pfam:RasIPI
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:04530ENTREZGENE
KEGG Pathway:05216ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:04810ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:04650ENTREZGENE
KEGG Pathway:05218ENTREZGENE
KEGG Pathway:04916ENTREZGENE
KEGG Pathway:04010ENTREZGENE
KEGG Pathway:04720ENTREZGENE
KEGG Pathway:04730ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:04912ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04540ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:04320ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
KEGG Pathway:05219ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04360ENTREZGENE
KEGG Pathway:05221ENTREZGENE
InterPro:Ras_GTPase.IPI
InterPro:GTPase_Ras.IPI
InterPro:Ras.IPI
InterPro:Ras_Ras_related.IPI
InterPro:Ras_small_GTPase.IPI
InterPro:Small_GTP_bd.IPI
Ensembl Protein:ENSRNOP00000012588IPI
Ensembl Protein:ENSRNOP00000012887IPI
IPI:IPI00210097IPI
IPI:IPI00203826IPI
Entrez Gene:KrasENTREZGENE
IMAGE_CLONE:IMAGE:8362025IMAGE-MGC_LOAD
MGC_CLONE:MGC:156626IMAGE-MGC_LOAD
UniProt:RASK_RATIPI
UniProt:RASK_RATIPI
UniProt:A0JN17_RATIPI
Ensembl Genes:ENSRNOG00000009338IPI
RatMap:34135ENTREZGENE
PANTHER:Ras_Ras_relatedIPI
TIGRFAMs:small_GTPIPI
PRINTS:RASTRNSFRMNG.IPI
Sequences
Nucleotide:NM_031515Get FASTASearch GEO Profiles
Nucleotide:CH473964Get FASTASearch GEO Profiles
Nucleotide:M12260Get FASTASearch GEO Profiles
Nucleotide:M54870Get FASTASearch GEO Profiles
Nucleotide:BC126086Get FASTASearch GEO Profiles
Nucleotide:U09793Get FASTASearch GEO Profiles
(View all 6 Nucleotide Accessions)
Protein:AAI26087Get FASTA
Protein:AAA42011Get FASTA
Protein:AAB60458Get FASTA
Protein:P08644Get FASTA
Protein:NP_113703Get FASTA
Protein:AAA40937Get FASTA
Protein:EDM01439Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene:24554
 
 References
Curated References
25 references in RGD related to Kras
Other References
25 other references at PubMed related to Kras
 
 Database Information
RGD ID2981
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
30-MAR-06: Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Kras2 Kirsten rat sarcoma viral oncogene homologue 2 (active) APPROVED Symbol and Name updated 1299863
10-JUN-02: Kras2 Kirsten rat sarcoma viral oncogene homologue 2 (active) APPROVED Symbol and Name status set to approved 70586

       

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