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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasaffects expressionEXP 6480464CTDbisphenol A affects the expression of KRAS mRNAPMID:25181051
Krasincreases expressionEXP 6480464CTDbisphenol A results in increased expression of KRAS mRNAPMID:29097150
Krasincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of KRAS genePMID:28505145
Krasdecreases expressionISOKRAS (Homo sapiens)6480464CTDbisphenol A results in decreased expression of KRAS mRNAPMID:16474171
Krasdecreases expressionISOKras (Mus musculus)6480464CTDbisphenol A results in decreased expression of KRAS mRNAPMID:33221593
Krasincreases expressionISOKRAS (Homo sapiens)6480464CTDbisphenol A results in increased expression of KRAS mRNAPMID:36982678
Krasincreases expressionISOKras (Mus musculus)6480464CTDbisphenol A results in increased expression of KRAS mRNAPMID:26063408
Krasincreases mutagenesisISOKRAS (Homo sapiens)6480464CTDbisphenol A results in increased mutagenesis of KRAS genePMID:11342245
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTD[bisphenol A co-treated with Quercetin metabolite] results in increased expression of KRAS mRNA; [bisphenol A co-treated with Quercetin] results in increased expression of KRAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNAPMID:36235125 PMID:36982678
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