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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasdecreases expressionISOKRAS (Homo sapiens)6480464CTDresveratrol results in decreased expression of KRAS mRNA; resveratrol results in decreased expression of KRAS proteinPMID:12002526 PMID:12569576 PMID:25280562 PMID:25667456
Krasdecreases expressionISOKras (Mus musculus)6480464CTDresveratrol results in decreased expression of KRAS protein mutant formPMID:25280562
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of KRAS mRNAPMID:23557933
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