Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

4 Annotations Found.

An association has been curated linking Kras and hepatocellular carcinoma in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with KRAS (Homo sapiens) [(EXP) inferred from experiment]
  • 949 RGD objects have been annotated to hepatocellular carcinoma  (DOID:684)
  • 91 papers in RGD have been used to annotate Kras
  • Curation Notes: CTD Direct Evidence: marker/mechanism
  • Original References(s): PMID:11286481 PMID:11563603


    • An association has been curated linking Kras and hepatocellular carcinoma in Rattus norvegicus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from Soman NR and Wogan GN, Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2045-9.
  • 5 additional annotations were made from Soman NR and Wogan GN, Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2045-9.
  • 949 RGD objects have been annotated to hepatocellular carcinoma  (DOID:684)
  • 91 papers in RGD have been used to annotate Kras
  • Qualifier: induced
  • Curation Notes: aflatoxin B1 induced:DNA:transversion,transition mutations:cds:


    • An association has been curated linking Kras and hepatocellular carcinoma in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Dietrich P, etal., Gut. 2018 Jul;67(7):1328-1341. doi: 10.1136/gutjnl-2017-315402. Epub 2017 Dec 23.
  • The annotation has been inferred from sequence orthology with KRAS (Homo sapiens) [(IEP) inferred from expression pattern]
  • 2 additional annotations were made from Dietrich P, etal., Gut. 2018 Jul;67(7):1328-1341. doi: 10.1136/gutjnl-2017-315402. Epub 2017 Dec 23.
  • 949 RGD objects have been annotated to hepatocellular carcinoma  (DOID:684)
  • 91 papers in RGD have been used to annotate Kras
  • Curation Notes: mRNA,protein:increased expression:liver


    • An association has been curated linking Kras and hepatocellular carcinoma in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with KRAS (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 949 RGD objects have been annotated to hepatocellular carcinoma  (DOID:684)
  • 91 papers in RGD have been used to annotate Kras
  • Curation Notes: ClinVar Annotator: match by term: Hepatocellular cancer
  • Original References(s): PMID:12460918 PMID:15696205 PMID:16361624 PMID:16434492 PMID:16618717 PMID:18316791 PMID:18794081 PMID:19075190 PMID:19114683 PMID:19679400 PMID:20921462 PMID:20921465 PMID:21228335 PMID:22407852 PMID:22722830 PMID:2278970 PMID:23325582 PMID:25157968 PMID:26619011 PMID:30891959 PMID:3122217


    • Go Back to source page   Continue to Ontology report