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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasaffects localizationISOKras (Mus musculus)6480464CTDDimethylnitrosamine affects the localization of KRAS proteinPMID:11884234
Krasmultiple interactionsISOKras (Mus musculus)6480464CTDDimethylnitrosamine results in decreased expression of and affects the localization of KRAS protein; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine affects the localization of KRAS protein]; Tetrachlorodibenzodioxin promotes the reaction [Dimethylnitrosamine results in decreased expression of KRAS protein]PMID:11884234 PMID:19555203
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