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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasincreases expressionEXP 6480464CTDOzone results in increased expression of KRAS mRNAPMID:16330353
Krasmultiple interactionsEXP 6480464CTD[[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of KRAS mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of KRAS mRNA; [Ozone co-treated with Chlorine] results in decreased expression of KRAS mRNAPMID:18636392 PMID:37088303
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTD[Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of KRAS mRNA; [Oxygen co-treated with Ozone] results in decreased expression of KRAS mRNAPMID:32992648
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