Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of KRAS mRNAPMID:33453195
Krasincreases expressionISOKRAS (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of KRAS mRNA; Cadmium Chloride results in increased expression of KRAS proteinPMID:23811327 PMID:26472689 PMID:27510461 PMID:32512071
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTDKRAS protein inhibits the reaction [Cadmium Chloride results in decreased expression of MIR155 mRNA]; KRAS protein inhibits the reaction [Cadmium Chloride results in decreased expression of MIR205 mRNA]; KRAS protein inhibits the reaction [Cadmium Chloride results in increased expression of MIR134 mRNA]; KRAS protein promotes the reaction [Cadmium Chloride results in increased expression of MAPK1 protein modified form]; KRAS protein promotes the reaction [Cadmium Chloride results in increased expression of MAPK3 protein modified form]; KRAS protein promotes the reaction [Cadmium Chloride results in increased secretion of MMP2 protein]PMID:27510461
Go Back to source page   Continue to Ontology report