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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasdecreases expressionISOKRAS (Homo sapiens)6480464CTDQuercetin results in decreased expression of KRAS mRNA; Quercetin results in decreased expression of KRAS proteinPMID:10652438 PMID:9381980
Krasincreases expressionISOKRAS (Homo sapiens)6480464CTDQuercetin metabolite results in increased expression of KRAS mRNA; Quercetin results in increased expression of KRAS mRNAPMID:36982678
Krasmultiple interactionsISOKRAS (Homo sapiens)6480464CTD[bisphenol A co-treated with Quercetin metabolite] results in increased expression of KRAS mRNA; [bisphenol A co-treated with Quercetin] results in increased expression of KRAS mRNA; Quercetin inhibits the reaction [KRAS protein affects the activity of TP53 protein]PMID:19424582 PMID:36982678
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