ANGIOTENSIN II SIGNALING PATHWAY VIA AT2 RECEPTOR (PW:0000528)
Description
Angiotensin II (AgtII), the product of Ace action in the renin-angiotensin pathway, is probably the most potent of the biologically active peptides the system generates. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Signaling via receptor type 1 is by far the better understood system. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially harmful effects elicited by Agtr1 can be counterbalanced by the Agtr2 mediated signaling. The pathway mediated by receptor type 2 promotes vasodilation and natriuresis and exerts anti-inflammatory and anti-proliferative effects. It may also stimulate the production of nitric oxide (NO), cyclic GMP (cGMP) and bradykinin (not shown). Synthetic Agtr1 receptor antagonists, such as the frequently prescribed Losartan, are used as antihypertensive agents. Agtr2 can exert a comparable effect which may be overshadowed by the rather low level of expression the receptor has. Agtr2 is highly expressed in the fetus but declines abruptly in the neonatal period, except for a number of tissues. The receptor continues to be expressed in the adult kidney, heart, adrenal cortex and other specific sites including certain areas of the brain. Both receptors are seven transmembrane G-coupled protein (GPCR) receptors but the exhibit low sequence homology - 34%. They employ distinct heterotrimeric G proteins and both, particularly Agtr2, can elicit signals in the absence of G protein coupling. While the detailed molecular mechanisms of Agtr2 mediated signaling are still elusive, available data point to a number of aspects. The G protein coupled signaling engages the Gnai2 and 3 of the Galphai family. Activation of phosphotyrosine phosphatases proceeds in both a G protein- dependent and independent manner and leads to inhibition of the extracellular signal-regulated Raf/Mek/Erk MAP kinase signaling. For instance, activation of Dusp1 (known as Mkp-1) is G-protein dependent, whereas the activation of Ptpn6 (Known as Shp-1) is G-protein independent. The essential difference between Agtr1 and Agtr2 effects on this MAP kinase pathway may be one of the mechanisms thereby Agtr2 opposes some of Agrt1 actions. Several binding partners have been identified of which Mtus1, known as Atip1 is the best characterized and may be involved in receptor trafficking and intracellular signaling independent of coupling to heterotrimeric G proteins. Several transcripts have been identified for the human MTUS1 that results from alternative splicing and promoter usage. In addition to Mtus1, a number of other Agtr2 interacting partners have been identified that include Erbb3, Plzf, Cnk1, Nhe6, and Timp3 and which contact the same C-terminal intracellular region of the receptor. Overall, the Agtr2-protein interactions appear to confer a tumor suppressing function.
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Pathway Diagram:
Genes in Pathway:
G
Agt angiotensinogen
IMP TAS ISO RGD
PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434 , RGD:1582435 , RGD:7401256
NCBI chr19:52,529,139...52,549,618
G
Agtr2 angiotensin II receptor, type 2
TAS ISO RGD
PMID:10977869 PMID:22949090 RGD:1581825 , RGD:7401256
NCBI chr X:112,119,876...112,124,060
G
Cnksr1 connector enhancer of kinase suppressor of Ras 1
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr 5:146,447,495...146,458,332
G
Dusp1 dual specificity phosphatase 1
TAS RGD
PMID:18804122 RGD:5133675
NCBI chr10:16,680,478...16,683,275
G
Erbb3 erb-b2 receptor tyrosine kinase 3
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr 7:994,549...1,015,876
G
Gnai2 G protein subunit alpha i2
ISO RGD
PMID:22949090 RGD:7401256
NCBI chr 8:108,288,401...108,309,009
G
Gnai3 G protein subunit alpha i3
ISO RGD
PMID:22949090 RGD:7401256
NCBI chr 2:195,742,765...195,780,720
G
Mtus1 microtubule associated scaffold protein 1
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr16:51,202,497...51,347,794
G
Ptpn6 protein tyrosine phosphatase, non-receptor type 6
ISO RGD
PMID:18804122 RGD:5133675
NCBI chr 4:157,526,034...157,550,783
G
Slc9a6 solute carrier family 9 member A6
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr X:134,430,677...134,486,747
G
Timp3 TIMP metallopeptidase inhibitor 3
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr 7:17,520,827...17,571,850
G
Zbtb16 zinc finger and BTB domain containing 16
ISO RGD
PMID:20889352 RGD:5133679
NCBI chr 8:48,989,376...49,177,011
Pathway Gene Annotations
Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Agt abdominal aortic aneurysm , Actin-Accumulation Myopathy , Albuminuria , alcoholic cardiomyopathy , alcoholic hepatitis , Alkalosis , allergic disease , Alzheimer's disease , Anaphylaxis , anemia , anti-basement membrane glomerulonephritis , anuria , aortic aneurysm , Aortic Calcification , Aortic Coarctation , atherosclerosis , atrial fibrillation , bipolar disorder , Bradycardia , breast cancer , Cardiac Arrhythmias , Cardiomegaly , cardiomyopathy , Cardiotoxicity , Cardiovascular Abnormalities , cardiovascular system disease , carotid artery disease , Catalepsy , cerebrovascular disease , Chemical and Drug Induced Liver Injury , cholestasis , Chronic Intermittent Hypoxia , chronic myeloid leukemia , cleidocranial dysplasia , cognitive disorder , congenital disorder of glycosylation type IIq , congestive heart failure , corneal neovascularization , coronary artery disease , COVID-19 , Crohn's disease , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic retinopathy , Diaphragmatic Hernia , diffuse scleroderma , dilated cardiomyopathy , Dissecting Aneurysm , Drug Overdose , end stage renal disease , endomyocardial fibrosis , essential hypertension , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Fabry disease , Fetal Growth Retardation , Fibrosis , focal segmental glomerulosclerosis , gastric ulcer , gastrointestinal stromal tumor , genetic disease , glomerulonephritis , glucose intolerance , heart disease , Hemorrhage , Henoch-Schoenlein purpura , hydronephrosis , Hyperalgesia , Hyperemia , hyperhomocysteinemia , hyperinsulinism , hypertension , Hypertensive Nephropathy , hypertrophic cardiomyopathy , Hypertrophy , hypokalemia , Hypotension , IgA glomerulonephritis , impotence , Inflammation , inflammatory bowel disease , intermediate coronary syndrome , Intestinal Reperfusion Injury , kidney disease , kidney failure , Left Ventricular Hypertrophy , liver cirrhosis , malignant hypertension , meconium aspiration syndrome , Metabolic Syndrome , microcephaly , middle cerebral artery infarction , mitral valve prolapse , multiple sclerosis , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Necrosis , Neointima , nephrosis , Neurobehavioral Manifestations , obesity , oligohydramnios , otosclerosis , parathyroid carcinoma , Peptic Ulcer Hemorrhage , pneumonia , polycystic kidney disease , pre-eclampsia , prediabetes syndrome , Pregnancy-Induced Hypertension , Prenatal Exposure Delayed Effects , primary biliary cholangitis , proteinuria , pulmonary edema , pulmonary fibrosis , pulmonary hypertension , Puromycin Aminonucleoside Nephrosis , renal hypertension , Renal Tubular Dysgenesis , Reperfusion Injury , retinal vasculitis , retinopathy of prematurity , sciatic neuropathy , sick sinus syndrome , skin melanoma , Stroke , Sudden Death , systemic scleroderma , temporal lobe epilepsy , thrombosis , transient cerebral ischemia , type 2 diabetes mellitus , ureteral obstruction , vascular disease , Vascular Malformations , Vascular Remodeling , Ventricular Dysfunction, Left , Ventricular Remodeling Agtr2 AIDS-Associated Nephropathy , Alveolar Bone Loss , asthma , autistic disorder , Brain Hypoxia-Ischemia , breast lobular carcinoma , chronic kidney disease , congenital diaphragmatic hernia , congestive heart failure , Diabetic Cardiomyopathies , Diabetic Nephropathies , dilated cardiomyopathy , end stage renal disease , Endotoxemia , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Fetal Growth Retardation , Fibrosis , focal segmental glomerulosclerosis , glomerulonephritis , glomerulosclerosis , hypertension , hypoglycemia , IgA glomerulonephritis , Inflammation , Insulin Resistance , intellectual disability , Left Ventricular Hypertrophy , meconium aspiration syndrome , Neoplasm Metastasis , non-syndromic X-linked intellectual disability 88 , obesity , ovarian cyst , pancreatic cancer , Prenatal Exposure Delayed Effects , pulmonary fibrosis , renal cell carcinoma , renovascular hypertension , Reperfusion Injury , Stomach Neoplasms , Stroke , syndromic X-linked intellectual disability Lubs type , systemic lupus erythematosus , type 2 diabetes mellitus , Urogenital Abnormalities , Vascular System Injuries , vesicoureteral reflux , X-Linked Intellectual Developmental Disorders Cnksr1 autosomal recessive hypercholesterolemia , intellectual disability , Neurodevelopmental Disorders , retinitis pigmentosa 59 , Usher syndrome type 2C Dusp1 Amyloid Neuropathies , anti-basement membrane glomerulonephritis , arteriosclerosis , atrial heart septal defect 7 , Atrial Septal Defect with Atrioventricular Conduction Defects , breast cancer , Carotid Artery Injuries , colitis , contact dermatitis , COVID-19 , diabetic encephalopathy , endometriosis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Fetal Growth Retardation , glucose intolerance , Huntington's disease , hydrocephalus , Hyperalgesia , hypertension , Intimal Hyperplasia , juvenile rheumatoid arthritis , Left Ventricular Hypertrophy , leishmaniasis , major depressive disorder , Myocardial Ischemia , obesity , otitis media , ovarian carcinoma , pancreatitis , portal hypertension , prostate cancer , psoriasis , Retina Reperfusion Injury , Spinal Cord Injuries , Spine Osteoarthritis , squamous cell carcinoma , transient cerebral ischemia , type 1 diabetes mellitus , urinary bladder cancer , visual epilepsy Erbb3 amblyopia , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , Colorectal Neoplasms , disease of cellular proliferation , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , Experimental Mammary Neoplasms , Familial Erythroleukemia , Familial Visceral Neuropathy , gallbladder carcinoma , Gallbladder Neoplasms , gastric adenocarcinoma , hepatocellular carcinoma , intestinal pseudo-obstruction , laryngeal squamous cell carcinoma , lethal congenital contracture syndrome 2 , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , median neuropathy , Mouth Neoplasms , nasopharynx carcinoma , Neoplasm Metastasis , neuronal intestinal dysplasia type A , Ovarian Neoplasms , Phyllodes Tumor , prostate cancer , Prostatic Neoplasms , Recurrence , Spinal Cord Injuries , stomach carcinoma , Stomach Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , urinary bladder cancer , Urinary Bladder Neoplasm , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Wallerian Degeneration Gnai2 Adrenal Cortex Neoplasms , Aicardi-Goutieres Syndrome 1 , Animal Mammary Neoplasms , atrioventricular block , Bradycardia , Breast Neoplasms , carcinoma , Cardiac Arrhythmias , developmental and epileptic encephalopathy , disease by infectious agent , Dwarfism , early infantile epileptic encephalopathy , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Familial Isolated Pituitary Adenoma , Familial Ventricular Tachycardia , granulosa cell tumor , Granulosa Cell Tumor of the Ovary , hypertension , hypopituitarism , inflammatory bowel disease 12 , long QT syndrome , Neoplasm Recurrence, Local , Ovarian Granulosa Cell Tumor , pituitary-dependent Cushing's disease , primary ciliary dyskinesia , Reperfusion Injury , Thecoma , Ventricular Tachycardia Gnai3 achromatopsia 4 , amnestic disorder , Auriculocondylar Syndrome , Auriculocondylar Syndrome 1 , autistic disorder , genetic disease , hereditary spastic paraplegia 63 , hypertension , Reperfusion Injury Mtus1 breast carcinoma , colon cancer , gallbladder carcinoma , hereditary spastic paraplegia 53 , ovarian carcinoma , salivary gland adenoid cystic carcinoma , tongue squamous cell carcinoma Ptpn6 anogenital venereal wart , autism spectrum disorder , calcinosis , cervical cancer , developmental and epileptic encephalopathy 21 , heart valve disease , Hyperphosphatemic Familial Tumoral Calcinosis 1 , Klippel-Feil syndrome 3 , lymphoproliferative syndrome 2 , Neurodevelopmental Disorders , peroxisome biogenesis disorder 2B , respiratory allergy , Temtamy syndrome Slc9a6 astigmatism , autistic disorder , Christianson syndrome , Congenital Heart Defects, Multiple Types, 1, X-Linked , Developmental Disabilities , genetic disease , intellectual disability , Neurodevelopmental Disorders , syndromic X-linked intellectual disability Lubs type , X-linked hyper IgM syndrome Timp3 arteriovenous malformations of the brain , asthma , bladder disease , breast cancer , breast carcinoma , choriocarcinoma , colitis , dilated cardiomyopathy , Endometrial Neoplasms , Endotoxemia , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Femoral Fractures , fundus dystrophy , Hereditary Eye Diseases , Kidney Neoplasms , liver disease , lung adenocarcinoma , lung non-small cell carcinoma , Lymphatic Metastasis , macular degeneration , muscular dystrophy-dystroglycanopathy type B6 , Neoplasm Invasiveness , Ovarian Neoplasms , preretinal fibrosis , prostate cancer , Pseudoinflammatory Fundus Dystrophy, Finnish Type , renal cell carcinoma , Reperfusion Injury , schistosomiasis , sciatic neuropathy , Sorsby's fundus dystrophy , Spontaneous Abortions , Stomach Neoplasms , thoracic aortic aneurysm , toxic encephalopathy , type 2 diabetes mellitus , urinary bladder cancer , Uterine Cervical Neoplasms , Wallerian Degeneration Zbtb16 acute promyelocytic leukemia , acute promyelocytic leukemia with PLZF/RARA , caudal regression syndrome , Chromosome 11, Partial Trisomy 11q , intellectual disability , Neoplasm Invasiveness , polydactyly , Prostatic Neoplasms , Skeletal Defects, Genital Hypoplasia, And Mental Retardation
abdominal aortic aneurysm Agt achromatopsia 4 Gnai3 Actin-Accumulation Myopathy Agt acute promyelocytic leukemia Zbtb16 acute promyelocytic leukemia with PLZF/RARA Zbtb16 Adrenal Cortex Neoplasms Gnai2 Aicardi-Goutieres Syndrome 1 Gnai2 AIDS-Associated Nephropathy Agtr2 Albuminuria Agt alcoholic cardiomyopathy Agt alcoholic hepatitis Agt Alkalosis Agt allergic disease Agt Alveolar Bone Loss Agtr2 Alzheimer's disease Agt amblyopia Erbb3 amnestic disorder Gnai3 Amyloid Neuropathies Dusp1 Anaphylaxis Agt anemia Agt Animal Mammary Neoplasms Gnai2 anogenital venereal wart Ptpn6 anti-basement membrane glomerulonephritis Agt , Dusp1 anuria Agt aortic aneurysm Agt Aortic Calcification Agt Aortic Coarctation Agt arteriosclerosis Dusp1 arteriovenous malformations of the brain Timp3 asthma Agtr2 , Timp3 astigmatism Slc9a6 atherosclerosis Agt atrial fibrillation Agt atrial heart septal defect 7 Dusp1 Atrial Septal Defect with Atrioventricular Conduction Defects Dusp1 atrioventricular block Gnai2 Auriculocondylar Syndrome Gnai3 Auriculocondylar Syndrome 1 Gnai3 autism spectrum disorder Ptpn6 autistic disorder Agtr2 , Gnai3 , Slc9a6 autosomal recessive hypercholesterolemia Cnksr1 bipolar disorder Agt bladder disease Timp3 Bradycardia Agt , Gnai2 Brain Hypoxia-Ischemia Agtr2 breast cancer Agt , Dusp1 , Timp3 breast carcinoma Mtus1 , Timp3 breast lobular carcinoma Agtr2 Breast Neoplasms Erbb3 , Gnai2 calcinosis Ptpn6 carcinoma Gnai2 Cardiac Arrhythmias Agt , Gnai2 Cardiomegaly Agt cardiomyopathy Agt Cardiotoxicity Agt Cardiovascular Abnormalities Agt cardiovascular system disease Agt carotid artery disease Agt Carotid Artery Injuries Dusp1 Catalepsy Agt caudal regression syndrome Zbtb16 cerebrovascular disease Agt cervical cancer Ptpn6 Chemical and Drug Induced Liver Injury Agt cholestasis Agt choriocarcinoma Timp3 Christianson syndrome Slc9a6 Chromosome 11, Partial Trisomy 11q Zbtb16 Chronic Intermittent Hypoxia Agt chronic kidney disease Agtr2 chronic myeloid leukemia Agt chronic obstructive pulmonary disease Erbb3 cleidocranial dysplasia Agt cognitive disorder Agt colitis Dusp1 , Timp3 colon cancer Mtus1 Colonic Neoplasms Erbb3 colorectal adenocarcinoma Erbb3 Colorectal Neoplasms Erbb3 congenital diaphragmatic hernia Agtr2 congenital disorder of glycosylation type IIq Agt Congenital Heart Defects, Multiple Types, 1, X-Linked Slc9a6 congestive heart failure Agt , Agtr2 contact dermatitis Dusp1 corneal neovascularization Agt coronary artery disease Agt COVID-19 Agt , Dusp1 Crohn's disease Agt developmental and epileptic encephalopathy Gnai2 developmental and epileptic encephalopathy 21 Ptpn6 Developmental Disabilities Slc9a6 Diabetic Cardiomyopathies Agt , Agtr2 diabetic encephalopathy Dusp1 Diabetic Nephropathies Agt , Agtr2 diabetic retinopathy Agt Diaphragmatic Hernia Agt diffuse scleroderma Agt dilated cardiomyopathy Agt , Agtr2 , Timp3 disease by infectious agent Gnai2 disease of cellular proliferation Erbb3 Disease Progression Erbb3 Dissecting Aneurysm Agt Drug Overdose Agt ductal carcinoma in situ Erbb3 Dwarfism Gnai2 early infantile epileptic encephalopathy Gnai2 end stage renal disease Agt , Agtr2 Endometrial Neoplasms Erbb3 , Timp3 Endometrioid Carcinomas Erbb3 endometriosis Dusp1 endomyocardial fibrosis Agt Endotoxemia Agtr2 , Timp3 essential hypertension Agt Experimental Autoimmune Encephalomyelitis Timp3 Experimental Diabetes Mellitus Agt , Agtr2 , Dusp1 , Timp3 Experimental Liver Cirrhosis Agt , Gnai2 Experimental Mammary Neoplasms Agt , Agtr2 , Dusp1 , Erbb3 , Gnai2 Experimental Radiation Injuries Agtr2 Fabry disease Agt Familial Erythroleukemia Erbb3 Familial Isolated Pituitary Adenoma Gnai2 Familial Ventricular Tachycardia Gnai2 Familial Visceral Neuropathy Erbb3 Femoral Fractures Timp3 Fetal Growth Retardation Agt , Agtr2 , Dusp1 Fibrosis Agt , Agtr2 focal segmental glomerulosclerosis Agt , Agtr2 fundus dystrophy Timp3 gallbladder carcinoma Erbb3 , Mtus1 Gallbladder Neoplasms Erbb3 gastric adenocarcinoma Erbb3 gastric ulcer Agt gastrointestinal stromal tumor Agt genetic disease Agt , Gnai3 , Slc9a6 glomerulonephritis Agt , Agtr2 glomerulosclerosis Agtr2 glucose intolerance Agt , Dusp1 granulosa cell tumor Gnai2 Granulosa Cell Tumor of the Ovary Gnai2 heart disease Agt heart valve disease Ptpn6 Hemorrhage Agt Henoch-Schoenlein purpura Agt hepatocellular carcinoma Erbb3 Hereditary Eye Diseases Timp3 hereditary spastic paraplegia 53 Mtus1 hereditary spastic paraplegia 63 Gnai3 Huntington's disease Dusp1 hydrocephalus Dusp1 hydronephrosis Agt Hyperalgesia Agt , Dusp1 Hyperemia Agt hyperhomocysteinemia Agt hyperinsulinism Agt Hyperphosphatemic Familial Tumoral Calcinosis 1 Ptpn6 hypertension Agt , Agtr2 , Dusp1 , Gnai2 , Gnai3 Hypertensive Nephropathy Agt hypertrophic cardiomyopathy Agt Hypertrophy Agt hypoglycemia Agtr2 hypokalemia Agt hypopituitarism Gnai2 Hypotension Agt IgA glomerulonephritis Agt , Agtr2 impotence Agt Inflammation Agt , Agtr2 inflammatory bowel disease Agt inflammatory bowel disease 12 Gnai2 Insulin Resistance Agtr2 intellectual disability Agtr2 , Cnksr1 , Slc9a6 , Zbtb16 intermediate coronary syndrome Agt intestinal pseudo-obstruction Erbb3 Intestinal Reperfusion Injury Agt Intimal Hyperplasia Dusp1 juvenile rheumatoid arthritis Dusp1 kidney disease Agt kidney failure Agt Kidney Neoplasms Timp3 Klippel-Feil syndrome 3 Ptpn6 laryngeal squamous cell carcinoma Erbb3 Left Ventricular Hypertrophy Agt , Agtr2 , Dusp1 leishmaniasis Dusp1 lethal congenital contracture syndrome 2 Erbb3 liver cirrhosis Agt liver disease Timp3 long QT syndrome Gnai2 lung adenocarcinoma Erbb3 , Timp3 Lung Neoplasms Erbb3 lung non-small cell carcinoma Erbb3 , Timp3 Lymphatic Metastasis Erbb3 , Timp3 lymphoproliferative syndrome 2 Ptpn6 macular degeneration Timp3 major depressive disorder Dusp1 malignant hypertension Agt meconium aspiration syndrome Agt , Agtr2 median neuropathy Erbb3 Metabolic Syndrome Agt microcephaly Agt middle cerebral artery infarction Agt mitral valve prolapse Agt Mouth Neoplasms Erbb3 multiple sclerosis Agt muscular dystrophy-dystroglycanopathy type B6 Timp3 myocardial infarction Agt Myocardial Ischemia Agt , Dusp1 Myocardial Reperfusion Injury Agt nasopharynx carcinoma Erbb3 Necrosis Agt Neointima Agt Neoplasm Invasiveness Timp3 , Zbtb16 Neoplasm Metastasis Agtr2 , Erbb3 Neoplasm Recurrence, Local Gnai2 nephrosis Agt Neurobehavioral Manifestations Agt Neurodevelopmental Disorders Cnksr1 , Ptpn6 , Slc9a6 neuronal intestinal dysplasia type A Erbb3 non-syndromic X-linked intellectual disability 88 Agtr2 obesity Agt , Agtr2 , Dusp1 oligohydramnios Agt otitis media Dusp1 otosclerosis Agt ovarian carcinoma Dusp1 , Mtus1 ovarian cyst Agtr2 Ovarian Granulosa Cell Tumor Gnai2 Ovarian Neoplasms Erbb3 , Timp3 pancreatic cancer Agtr2 pancreatitis Dusp1 parathyroid carcinoma Agt Peptic Ulcer Hemorrhage Agt peroxisome biogenesis disorder 2B Ptpn6 Phyllodes Tumor Erbb3 pituitary-dependent Cushing's disease Gnai2 pneumonia Agt polycystic kidney disease Agt polydactyly Zbtb16 portal hypertension Dusp1 pre-eclampsia Agt prediabetes syndrome Agt Pregnancy-Induced Hypertension Agt Prenatal Exposure Delayed Effects Agt , Agtr2 preretinal fibrosis Timp3 primary biliary cholangitis Agt primary ciliary dyskinesia Gnai2 prostate cancer Dusp1 , Erbb3 , Timp3 Prostatic Neoplasms Erbb3 , Zbtb16 proteinuria Agt Pseudoinflammatory Fundus Dystrophy, Finnish Type Timp3 psoriasis Dusp1 pulmonary edema Agt pulmonary fibrosis Agt , Agtr2 pulmonary hypertension Agt Puromycin Aminonucleoside Nephrosis Agt Recurrence Erbb3 renal cell carcinoma Agtr2 , Timp3 renal hypertension Agt Renal Tubular Dysgenesis Agt renovascular hypertension Agtr2 Reperfusion Injury Agt , Agtr2 , Gnai2 , Gnai3 , Timp3 respiratory allergy Ptpn6 Retina Reperfusion Injury Dusp1 retinal vasculitis Agt retinitis pigmentosa 59 Cnksr1 retinopathy of prematurity Agt salivary gland adenoid cystic carcinoma Mtus1 schistosomiasis Timp3 sciatic neuropathy Agt , Timp3 sick sinus syndrome Agt Skeletal Defects, Genital Hypoplasia, And Mental Retardation Zbtb16 skin melanoma Agt Sorsby's fundus dystrophy Timp3 Spinal Cord Injuries Dusp1 , Erbb3 Spine Osteoarthritis Dusp1 Spontaneous Abortions Timp3 squamous cell carcinoma Dusp1 stomach carcinoma Erbb3 Stomach Neoplasms Agtr2 , Erbb3 , Timp3 Stroke Agt , Agtr2 Sudden Death Agt syndromic X-linked intellectual disability Lubs type Agtr2 , Slc9a6 systemic lupus erythematosus Agtr2 systemic scleroderma Agt temporal lobe epilepsy Agt Temtamy syndrome Ptpn6 Thecoma Gnai2 thoracic aortic aneurysm Timp3 thrombosis Agt tongue squamous cell carcinoma Erbb3 , Mtus1 toxic encephalopathy Timp3 transient cerebral ischemia Agt , Dusp1 transitional cell carcinoma Erbb3 type 1 diabetes mellitus Dusp1 type 2 diabetes mellitus Agt , Agtr2 , Timp3 ureteral obstruction Agt urinary bladder cancer Dusp1 , Erbb3 , Timp3 Urinary Bladder Neoplasm Erbb3 Urogenital Abnormalities Agtr2 Usher syndrome type 2C Cnksr1 uterine cancer Erbb3 uterine carcinosarcoma Erbb3 Uterine Cervical Neoplasms Erbb3 , Timp3 vascular disease Agt Vascular Malformations Agt Vascular Remodeling Agt Vascular System Injuries Agtr2 Ventricular Dysfunction, Left Agt Ventricular Remodeling Agt Ventricular Tachycardia Gnai2 vesicoureteral reflux Agtr2 visual epilepsy Dusp1 Wallerian Degeneration Erbb3 , Timp3 X-linked hyper IgM syndrome Slc9a6 X-Linked Intellectual Developmental Disorders Agtr2
