ONTOLOGY REPORT - ANNOTATIONS

Term:G protein mediated signaling pathway via Galphai family
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Accession:PW:0000228 term browser browse the term
Definition:Based on sequence similarity, the Galpha genes have been grouped into four classes. Exchange of GDP to GTP promoted through binding to receptors dissociates the heterotrimeric Galpha/beta/gamma complex. GTP-bound Galpha can then interact with downstream effectors. Lipid modification of Galpha regulates membrane localization and interactions with specific effectors.

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G protein mediated signaling pathway via Galphai family term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adrb2 adrenoceptor beta 2, surface GBrowse link IMP 18 58,174,958 58,177,000 RGD:1559319 RGD
G Agtr2 angiotensin II receptor, type 2 TAS RGD:1566502 RGD
G Casr calcium-sensing receptor GBrowse link IMP 11 66,084,169 66,153,292 RGD:7207059 RGD
G Drd2 dopamine receptor D2 GBrowse link ISS 8 52,641,160 52,707,749 RGD:1581445 RGD
G Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 GBrowse link IMP 4 12,465,089 12,495,028 RGD:1642020 RGD
G Hcrtr2 hypocretin (orexin) receptor 2 GBrowse link IDA 8 81,068,303 81,196,608 RGD:1642020 RGD
G Lpar1 lysophosphatidic acid receptor 1 GBrowse link IMP 5 76,449,470 76,571,458 RGD:1626474 RGD
G Lpar3 lysophosphatidic acid receptor 3 GBrowse link IMP 2 244,431,789 244,510,815 RGD:1626474 RGD
G Oxtr oxytocin receptor GBrowse link ISS 4 148,314,089 148,326,797 RGD:1579893 RGD
G Oxtr oxytocin receptor GBrowse link IMP 4 148,314,089 148,326,797 RGD:2304227 RGD
G Rgs4 regulator of G-protein signaling 4 GBrowse link ISS 13 85,533,882 85,540,173 RGD:7207227 RGD
G Rgs5 regulator of G-protein signaling 5 GBrowse link ISS 13 85,445,325 85,482,294 RGD:7207228 RGD
G S1pr1 sphingosine-1-phosphate receptor 1 GBrowse link IMP 2 211,851,304 211,855,511 RGD:1581747 RGD
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Path 1
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  Pathway Ontology 17154
    signaling pathway 7601
      G protein mediated signaling pathway 91
        G protein mediated signaling pathway via Galphai family 13
Path 2
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  Pathway Ontology 17154
    signaling pathway 7601
      signaling pathway pertinent to the brain 586
        neuron-to-neuron signaling pathways 405
          neuron-to-neuron signaling pathway via the chemical synapse 403
            excitatory synaptic transmission pathway 342
              glutamate signaling pathway 176
                glutamate signaling pathway via metabotropic glutamate receptor 50
                  glutamate signaling pathway via group II or III glutamate receptor 13
                    G protein mediated signaling pathway via Galphai family 13
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