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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:renin-angiotensin cascade pathway
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Accession:PW:0000492 term browser browse the term
Definition:The renin-angiotensin cascade (RAS) generates a number of bioactive peptides with diverse physiological and pathophysiological functions. RAS exerts vasoconstriction, vasodilation or vascular remodeling, cell proliferation or anti-proliferation effects, depending on which angiotensin peptide generates the signaling. Some of these features are also shared by the kallikrein-kinin system (KKS); the two systems can interact and cross-talk.
Synonyms:related_synonym: KEGG:04614;   RAS system signaling pathway
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renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO
IEA
IMP		 KEGG
RGD		 PMID:15638741 PMID:10642323 rno:04614, RGD:1581742, RGD:1581953 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO
IEA		 KEGG
RGD		 PMID:15638741 PMID:16520407 rno:04614, RGD:1581742, RGD:1581931 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen IDA
IEA
IMP
ISO		 KEGG
RGD		 PMID:12242043 PMID:11282364 PMID:15638741 rno:04614, RGD:1581651, RGD:1582105, RGD:1581742 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IEA		 KEGG
RGD		 PMID:16141358 rno:04614, RGD:1581847 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS
IEA		 KEGG
RGD		 PMID:16141358 rno:04614, RGD:1581847 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
IEA		 KEGG
RGD		 PMID:15158138 rno:04614, RGD:1581855 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA
IEA		 KEGG
RGD		 PMID:16537183 rno:04614, RGD:1581649 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO RGD PMID:18376005 RGD:5132617 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Cma1 chymase 1 TAS
IEA		 KEGG
RGD		 PMID:15638741 rno:04614, RGD:1581742 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233 		JBrowse link
G Cpa3 carboxypeptidase A3 IEA KEGG rno:04614 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203 		JBrowse link
G Ctsa cathepsin A IEA KEGG rno:04614 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215 		JBrowse link
G Ctsg cathepsin G IEA KEGG rno:04614 NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353 		JBrowse link
G Enpep glutamyl aminopeptidase IDA
IEA
ISO		 KEGG
RGD		 PMID:16537183 PMID:15638741 rno:04614, RGD:1581649, RGD:1581742 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor IDA
TAS		 RGD PMID:11247783 PMID:16672920 RGD:1581738, RGD:1581739 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IEA
IMP		 KEGG
RGD		 PMID:15687842 PMID:11282364 rno:04614, RGD:1581849, RGD:1582105 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor TAS
IEA
ISO		 KEGG
RGD		 PMID:15687842 PMID:16520407 rno:04614, RGD:1581849, RGD:1581931 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mcpt8l2 mast cell protease 8-like 2 IEA KEGG rno:04614
G Mcpt8l3 mast cell protease 8-like 3 IEA KEGG rno:04614
G Mme membrane metallo-endopeptidase ISO
IEA
IMP		 KEGG
RGD		 PMID:15638741 PMID:10642323 PMID:16520407 rno:04614, RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Nln neurolysin IEA KEGG rno:04614 NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914 		JBrowse link
G Ren renin IDA
IEA
ISO
TAS		 KEGG
RGD		 PMID:12242043 PMID:15638741 PMID:16672920 PMID:11247783 rno:04614, RGD:1581651, RGD:1581742, RGD:1581739, RGD:1581738 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Renbp renin binding protein IDA RGD PMID:11726282 RGD:5132613 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Thop1 thimet oligopeptidase 1 IEA KEGG rno:04614 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275 		JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP
ISO		 RGD PMID:10642323 PMID:15283675 RGD:1581953, RGD:1598433 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen IMP RGD PMID:15951342 RGD:1581938 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor IMP
ISO		 RGD PMID:15951342 PMID:16520407 RGD:1581938, RGD:1581931 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mme membrane metallo-endopeptidase ISO
IMP		 RGD PMID:15638741 PMID:10642323 PMID:16520407 RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:15590154 RGD:1579760 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:14657020 RGD:1566502 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:14684844 RGD:1582323 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cma1 chymase 1 IMP RGD PMID:15869764 RGD:1581745 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233 		JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:16269269 RGD:1600094 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP RGD PMID:12661921 RGD:1580992 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IDA RGD PMID:14585963 RGD:1581775 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pla2g6 phospholipase A2 group VI IMP RGD PMID:17613534 RGD:12910844 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IMP
IDA		 RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Jak2 Janus kinase 2 IDA
IMP		 RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP
ISO
TAS		 RGD PMID:16286564 PMID:22949090 PMID:16286568 RGD:1582434, RGD:7401256, RGD:1582435 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO		 RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212 		JBrowse link
G Dusp1 dual specificity phosphatase 1 TAS RGD PMID:18804122 RGD:5133675 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:11295571 RGD:1582124 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:11295571 RGD:1582124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:11295571 RGD:1582124 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:11295571 RGD:1582124 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Enpep glutamyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11100981 RGD:1582152 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11100981 RGD:1582152 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b IMP RGD PMID:11100981 RGD:1582152 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:16380540 RGD:1582118 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:16380540 RGD:1582118 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11282364 RGD:1582105 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA RGD PMID:16537183 RGD:1581649 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IMP		 RGD PMID:12591177 PMID:11282364 RGD:1581864, RGD:1582105 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISS RGD PMID:12676165 RGD:1566511 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      peptide and protein metabolic pathway 78
        peptide and protein hormone metabolic pathway 62
          renin-angiotensin cascade pathway 52
            angiotensin signaling pathway + 41
paths to the root