letrozole - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	letrozole	go back to main search page
Accession:	CHEBI:6413	browse the term
Definition:	A triazole that has formula C17H11N5.
Synonyms:	exact_synonym:	4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile
	related_synonym:	Femara; Formula=C17H11N5; InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H; InChIKey=HPJKCIUCZWXJDR-UHFFFAOYSA-N; Letrozol; SMILES=N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1
	xref:	Beilstein:6813913; CAS:112809-51-5; DrugBank:DB01006; Drug_Central:1556; KEGG:C08163; KEGG:D00964; LINCS:LSM-3980
	xref_mesh:	MESH:C067431
	xref:	Patent:EP236940; Patent:US4978672; Wikipedia:Letrozole

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Genes (78)

letrozole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

Letrozole results in decreased expression of ADIPOQ protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenomedullin

increases expression
multiple interactions

Letrozole results in increased expression of ADM protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA]; ADM protein promotes the reaction [Letrozole results in increased expression of ADM protein]

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

AKT serine/threonine kinase 1

decreases expression
multiple interactions

Letrozole results in decreased expression of AKT1 mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

angiopoietin 2

multiple interactions

[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin 4

multiple interactions

[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT4 mRNA

NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583

G

androgen receptor

multiple interactions
decreases expression

diacerein inhibits the reaction [Letrozole results in decreased expression of AR mRNA]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activating transcription factor 6

increases expression
multiple interactions

Letrozole results in increased expression of ATF6 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Letrozole results in increased expression of BAX protein
ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 2

multiple interactions

[letrozole results in decreased abundance of Estradiol] which results in decreased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

catalase

decreases activity
multiple interactions

Letrozole results in decreased activity of CAT protein
diacerein inhibits the reaction [Letrozole results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

increases expression
multiple interactions

Letrozole results in increased expression of CCN2 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions
decreases expression

[Letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein; [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein; [Sorafenib co-treated with Letrozole] results in decreased expression of CCND1 protein
letrozole results in decreased expression of CCND1 protein

PMID:16033851 PMID:20054642

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
decreases expression

[letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
letrozole results in decreased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin-dependent kinase inhibitor 1A

increases expression

letrozole results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cytochrome c, somatic

multiple interactions

[Oleic Acid co-treated with letrozole] affects the localization of CYCS protein; [Olive Oil co-treated with letrozole] affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

diacerein inhibits the reaction [Letrozole results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression
multiple interactions
decreases expression

Letrozole results in increased expression of CYP17A1 mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
[Letrozole co-treated with tris(2,3-dibromopropyl)isocyanurate] results in decreased expression of CYP17A1 mRNA; diacerein inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
Letrozole results in decreased expression of CYP17A1 mRNA

PMID:32298659 PMID:37030623 PMID:37254606

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases activity
decreases expression

Letrozole inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; Letrozole inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [sodium arsenite results in increased expression of CYP19A1 mRNA]
Letrozole results in decreased activity of CYP19A1 protein
letrozole results in increased activity of CYP19A1 protein
letrozole results in decreased activity of CYP19A1 protein
letrozole binds to and results in decreased activity of CYP19A1 protein
Letrozole results in decreased expression of CYP19A1 mRNA
diacerein inhibits the reaction [Letrozole results in decreased expression of CYP19A1 mRNA]

PMID:15837728 PMID:15909811 PMID:15967659 PMID:16009161 PMID:16013988 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases oxidation

CYP3A4 protein results in increased oxidation of Letrozole

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases activity

letrozole results in decreased activity of CYP51A1 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Letrozole results in increased expression of DDIT3 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

letrozole results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

[letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; letrozole results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ETS transcription factor ELK1

increases expression

letrozole results in increased expression of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

endothelial PAS domain protein 1

multiple interactions

[letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

estrogen receptor 1

decreases expression
multiple interactions

Letrozole results in decreased expression of ESR1 mRNA
diacerein inhibits the reaction [Letrozole results in decreased expression of ESR1 mRNA]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

fibroblast growth factor 22

increases expression

letrozole results in increased expression of FGF22 mRNA

NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486

G

follicle stimulating hormone subunit beta

increases expression
multiple interactions
decreases secretion
decreases expression

letrozole results in increased expression of FSHB protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]
diacerein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]

PMID:15123030 PMID:31295448 PMID:33491863 PMID:37030623

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

multiple interactions
decreases expression

diacerein inhibits the reaction [Letrozole results in decreased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

gamma-glutamyltransferase 1

multiple interactions
increases activity

Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

decreases expression

letrozole results in decreased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

growth factor receptor bound protein 2

increases expression

letrozole results in increased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

glutathione-disulfide reductase

decreases expression
multiple interactions

Letrozole results in decreased expression of GSR protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

decreases expression
multiple interactions

letrozole results in decreased expression of HMOX1 protein
indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions

[Letrozole co-treated with tris(2,3-dibromopropyl)isocyanurate] results in decreased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

interleukin 10

increases expression
multiple interactions

letrozole results in increased expression of IL10 protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 6

increases expression
multiple interactions

Letrozole results in increased expression of IL6 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Letrozole results in increased expression of and results in increased secretion of IL6 protein; Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein]

PMID:33359182 PMID:33491863 PMID:37328115

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
increases expression

ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein]
diacerein inhibits the reaction [Letrozole results in increased expression of INS1 protein]

PMID:28619389 PMID:33359182 PMID:33491863 PMID:37030623

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

KIT ligand

multiple interactions
decreases expression

diacerein inhibits the reaction [Letrozole results in decreased expression of KITL mRNA]

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

lactate dehydrogenase A

increases activity
multiple interactions

Letrozole results in increased activity of LDHA protein
Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone subunit beta

increases expression
multiple interactions
increases secretion

letrozole results in increased expression of LHB protein
Letrozole results in increased expression of LHB protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]]; LHB protein inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]]; Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Niacinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]
diacerein inhibits the reaction [Letrozole results in increased expression of LHB protein]

PMID:15123030 PMID:16046582 PMID:28619389 PMID:31295448 PMID:32298659 More...

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions
decreases expression

diacerein inhibits the reaction [Letrozole results in decreased expression of LHR mRNA]

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

LIF, interleukin 6 family cytokine

increases expression

letrozole results in increased expression of LIF mRNA; letrozole results in increased expression of LIF protein

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

LIF receptor subunit alpha

increases expression

letrozole results in increased expression of LIFR mRNA

NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699

G

mitogen activated protein kinase kinase 1

increases expression

letrozole results in increased expression of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

increases expression

letrozole results in increased expression of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions

letrozole results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

letrozole results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

decreases expression

letrozole results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

multiple interactions

letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

multiple interactions

[Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[Sirolimus co-treated with letrozole] results in decreased expression of MYC protein; [sorafenib co-treated with letrozole] results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nicotinamide phosphoribosyltransferase

multiple interactions
increases expression

Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

proprotein convertase subtilisin/kexin type 9

multiple interactions

Letrozole results in increased expression of and results in increased secretion of PCSK9 protein; Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein]

NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

[letrozole results in decreased abundance of Estradiol] which results in decreased expression of PECAM1 protein

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

progesterone receptor

decreases expression

letrozole results in decreased expression of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases expression
multiple interactions

Letrozole results in decreased expression of PIK3CG mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prolactin

multiple interactions
increases expression

Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

letrozole results in increased expression of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RB transcriptional corepressor 1

multiple interactions

[letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; [sorafenib co-treated with letrozole] results in decreased expression of RB1 protein; letrozole results in decreased phosphorylation of and affects the activity of RB1 protein

PMID:16033851 PMID:20054642

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

resistin

increases expression
multiple interactions

Letrozole results in increased expression of RETN mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of RETN mRNA]

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

[letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein
letrozole results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase A1

multiple interactions

letrozole results in increased expression of and results in increased phosphorylation of RPS6KA1 protein

NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272

G

sex hormone binding globulin

decreases secretion
multiple interactions

Letrozole results in decreased secretion of SHBG protein
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein]

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

SHC adaptor protein 1

increases expression

letrozole results in increased expression of SHC1 protein

NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536

G

solute carrier family 22 member 2

multiple interactions

letrozole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 2 member 4

multiple interactions
decreases expression

Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]; Niacinamide inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

telomerase reverse transcriptase

multiple interactions

letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transforming growth factor, beta 1

multiple interactions
increases expression

ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]]

PMID:28619389 PMID:33491863

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
multiple interactions

Letrozole results in increased expression of TNF protein
ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]

PMID:28619389 PMID:33359182 PMID:33491863

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions
increases expression

diacerein inhibits the reaction [Letrozole results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

multiple interactions
increases expression

ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19838
chemical entity	19836
group	19795
pseudohalo group	4573
cyano group	4573
nitrile	4573
letrozole	78
Path 2
Term	Annotations
CHEBI ontology	19838
subatomic particle	19836
composite particle	19836
hadron	19836
baryon	19836
nucleon	19836
atomic nucleus	19836
atom	19836
main group element atom	19786
p-block element atom	19786
carbon group element atom	19734
carbon atom	19731
organic molecular entity	19731
organic molecule	19684
organic cyclic compound	19496
organic heterocyclic compound	18874
heteroarene	17135
monocyclic heteroarene	14869
azole	14371
triazoles	8140
letrozole	78

paths to the root