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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2630
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbdecreases expressionEXP 6480464CTDLetrozole results in decreased expression of FSHB proteinPMID:33491863
Fshbdecreases secretionEXP 6480464CTDLetrozole results in decreased secretion of FSHB proteinPMID:31295448
Fshbmultiple interactionsEXP 6480464CTDADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]PMID:31295448 PMID:33491863
Fshbdecreases expressionISOFshb (Mus musculus)6480464CTDLetrozole results in decreased expression of FSHB proteinPMID:37030623
Fshbincreases expressionISOFSHB (Homo sapiens)6480464CTDletrozole results in increased expression of FSHB proteinPMID:15123030
Fshbmultiple interactionsISOFshb (Mus musculus)6480464CTDdiacerein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]PMID:37030623
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