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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pinostrobin
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Accession:CHEBI:80491 term browser browse the term
Definition:A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.
Synonyms:exact_synonym: (2S)-5-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
 related_synonym: (2S)-5-hydroxy-7-methoxyflavanone;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1;   InChIKey=ORJDDOBAOGKRJV-AWEZNQCLSA-N;   Pinocembrin-7-methylether;   SMILES=COc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccccc1;   dihydrotectochrysin
 xref: CAS:480-37-5;   KEGG:C16419;   KNApSAcK:C00008144;   LIPID_MAPS_instance:LMPK12140216
 xref_mesh: MESH:C411294
 xref: PMID:24680612;   PMID:25138354;   PMID:25519455;   Reaxys:90359


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pinostrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of AARS1 mRNA CTD PMID:37777166 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
decreases activity		 ISO [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to pinostrobin		 CTD PMID:37259354 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acvr1 activin A receptor type 1 increases expression ISO pinostrobin results in increased expression of ACVR1 mRNA CTD PMID:37777166 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Ahctf1 AT hook containing transcription factor 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of AHCTF1 protein CTD PMID:37164308 NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391 		JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 increases expression ISO pinostrobin results in increased expression of AIFM3 mRNA CTD PMID:37777166 NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248 		JBrowse link
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 increases expression ISO pinostrobin results in increased expression of AREL1 mRNA CTD PMID:37777166 NCBI chr 6:104,560,556...104,617,712
Ensembl chr 6:104,564,986...104,617,628 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO pinostrobin results in increased expression of ASNS mRNA CTD PMID:37777166 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein CTD PMID:37208425 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO pinostrobin results in increased expression of ATP5F1A mRNA CTD PMID:37777166 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO pinostrobin results in increased expression of AXL mRNA CTD PMID:37777166 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pinostrobin results in increased expression of BAD mRNA CTD PMID:37777166 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pinostrobin results in increased expression of BAK1 mRNA CTD PMID:37164308 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]		 CTD PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO pinostrobin results in increased expression of BBC3 mRNA CTD PMID:37777166 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 pinostrobin results in decreased expression of BCL2 protein
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]		 CTD PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO pinostrobin results in increased expression of BCL2L11 mRNA CTD PMID:37777166 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression ISO pinostrobin results in decreased expression of BCL2L2 mRNA CTD PMID:37164308 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bmf Bcl2 modifying factor increases expression ISO pinostrobin results in increased expression of BMF mRNA CTD PMID:37777166 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 increases expression ISO pinostrobin results in increased expression of CALHM2 mRNA CTD PMID:37777166 NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218 		JBrowse link
G Capn3 calpain 3 increases expression ISO pinostrobin results in increased expression of CAPN3 mRNA CTD PMID:37777166 NCBI chr 3:107,407,518...107,457,858
Ensembl chr 3:107,407,850...107,457,858 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO
EXP		 pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein
pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein		 CTD PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression ISO pinostrobin results in increased expression of CASP8 mRNA CTD PMID:37208425 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression ISO pinostrobin results in increased expression of CASP9 mRNA CTD PMID:37208425 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbs cystathionine beta synthase increases expression ISO pinostrobin results in increased expression of CBS mRNA CTD PMID:37777166 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO pinostrobin results in decreased expression of CCNE1 protein CTD PMID:37777166 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd14 CD14 molecule increases expression ISO pinostrobin results in increased expression of CD14 mRNA CTD PMID:37777166 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO pinostrobin results in increased expression of CD70 mRNA CTD PMID:37777166 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cdc40 cell division cycle 40 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDC40 protein CTD PMID:37164308 NCBI chr20:44,273,080...44,325,605
Ensembl chr20:44,273,089...44,325,358 		JBrowse link
G Cdh1 cadherin 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDH1 protein CTD PMID:37164308 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein CTD PMID:37777166 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pinostrobin results in increased expression of CDKN1B protein CTD PMID:37777166 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO pinostrobin results in increased expression of CEBPB mRNA CTD PMID:37777166 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO pinostrobin results in increased expression of CHAC1 mRNA CTD PMID:37777166 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO pinostrobin results in increased expression of CIDEB mRNA CTD PMID:37777166 NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Cldn7 claudin 7 increases expression ISO pinostrobin results in increased expression of CLDN7 mRNA CTD PMID:37777166 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression ISO pinostrobin results in decreased expression of CRELD2 protein CTD PMID:37164308 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO pinostrobin results in increased expression of CTH mRNA CTD PMID:37777166 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein		 CTD PMID:37164308 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO pinostrobin results in increased expression of CXCR4 mRNA CTD PMID:37777166 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Dcps decapping enzyme, scavenger increases expression ISO pinostrobin results in increased expression of DCPS mRNA CTD PMID:37777166 NCBI chr 8:33,468,669...33,524,407
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pinostrobin results in increased expression of DDIT3 mRNA CTD PMID:37777166 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO pinostrobin results in increased expression of DDIT4 mRNA CTD PMID:37777166 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dnase1 deoxyribonuclease 1 increases expression ISO pinostrobin results in increased expression of DNASE1 mRNA CTD PMID:37777166 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO pinostrobin results in increased expression of DNASE2 mRNA CTD PMID:37777166 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Doc2b double C2 domain beta increases phosphorylation ISO pinostrobin results in increased phosphorylation of DOC2B protein CTD PMID:37164308 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267 		JBrowse link
G Elmo1 engulfment and cell motility 1 increases expression ISO pinostrobin results in increased expression of ELMO1 mRNA CTD PMID:37777166 NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression ISO pinostrobin results in increased expression of ERC1 mRNA CTD PMID:37777166 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases expression ISO pinostrobin results in increased expression of ERCC2 mRNA CTD PMID:37777166 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Etv6 ETS variant transcription factor 6 increases expression ISO pinostrobin results in increased expression of ETV6 mRNA CTD PMID:37777166 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992 		JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression ISO pinostrobin results in increased expression of FANK1 mRNA CTD PMID:37777166 NCBI chr 1:188,577,512...188,685,501
Ensembl chr 1:188,577,575...188,685,504 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pinostrobin results in increased expression of FAS mRNA CTD PMID:37208425 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbh1 F-box DNA helicase 1 increases expression ISO pinostrobin results in increased expression of FBH1 mRNA CTD PMID:37777166 NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590 		JBrowse link
G Fcmr Fc mu receptor increases expression ISO pinostrobin results in increased expression of FCMR mRNA CTD PMID:37777166 NCBI chr13:42,337,363...42,351,706
Ensembl chr13:42,337,414...42,351,653 		JBrowse link
G Fer1l4 fer-1-like family member 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of FER1L4 protein CTD PMID:37164308 NCBI chr 3:144,536,099...144,571,634
Ensembl chr 3:144,536,099...144,571,634 		JBrowse link
G Flcn folliculin increases expression ISO pinostrobin results in increased expression of FLCN mRNA CTD PMID:37777166 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases phosphorylation ISO pinostrobin results in decreased phosphorylation of FMO5 protein CTD PMID:37164308 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Foxa1 forkhead box A1 increases expression ISO pinostrobin results in increased expression of FOXA1 mRNA CTD PMID:37777166 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression		 ISO pinostrobin results in increased expression of and affects the localization of FOXO3 protein
pinostrobin results in increased expression of FOXO3 mRNA		 CTD PMID:37777166 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:37866152 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO pinostrobin results in increased expression of FYN mRNA CTD PMID:37777166 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO pinostrobin results in increased expression of GADD45A mRNA CTD PMID:37777166 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Glb1 galactosidase, beta 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of GLB1 protein CTD PMID:37164308 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO pinostrobin results in increased expression of GRINA mRNA CTD PMID:37777166 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366 		JBrowse link
G Grn granulin precursor increases expression ISO pinostrobin results in increased expression of GRN mRNA CTD PMID:37777166 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:37342552 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] CTD PMID:37342552 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hip1 huntingtin interacting protein 1 increases expression ISO pinostrobin results in increased expression of HIP1 mRNA CTD PMID:37777166 NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pinostrobin results in increased expression of HMOX1 mRNA CTD PMID:37777166 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing increases expression ISO pinostrobin results in increased expression of HSH2D mRNA CTD PMID:37777166 NCBI chr16:17,630,519...17,649,932
Ensembl chr16:17,635,322...17,647,991 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO pinostrobin results in increased expression of ID3 mRNA CTD PMID:37777166 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein] CTD PMID:38078205 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ing4 inhibitor of growth family, member 4 increases expression ISO pinostrobin results in increased expression of ING4 mRNA CTD PMID:37777166 NCBI chr 4:157,841,882...157,850,519
Ensembl chr 4:157,841,951...157,850,265 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pinostrobin results in increased expression of INHBA mRNA CTD PMID:37777166 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Ino80 INO80 complex ATPase subunit increases phosphorylation ISO pinostrobin results in increased phosphorylation of INO80 protein CTD PMID:37164308 NCBI chr 3:106,368,455...106,465,716
Ensembl chr 3:106,368,455...106,467,911 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression ISO pinostrobin results in increased expression of IRF7 mRNA CTD PMID:37777166 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO pinostrobin results in increased expression of ITGAM mRNA CTD PMID:37777166 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO pinostrobin results in increased expression of ITPK1 mRNA CTD PMID:37777166 NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107 		JBrowse link
G Kdm2b lysine demethylase 2B increases expression ISO pinostrobin results in increased expression of KDM2B mRNA CTD PMID:37777166 NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein] CTD PMID:37342552 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lgals2 galectin 2 increases expression ISO pinostrobin results in increased expression of LGALS2 mRNA CTD PMID:37777166 NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:37866152 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO pinostrobin results in increased expression of MADD mRNA CTD PMID:37777166 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO pinostrobin results in decreased expression of MCL1 mRNA CTD PMID:37164308 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO pinostrobin results in increased expression of MEF2A mRNA CTD PMID:37777166 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO pinostrobin results in increased expression of MEF2D mRNA CTD PMID:37777166 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457 		JBrowse link
G Mir410 microRNA 410 decreases expression
multiple interactions		 ISO pinostrobin results in decreased expression of MIR410 mRNA
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]		 CTD PMID:37164308 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434 		JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of MRPL1 protein CTD PMID:37164308 NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO pinostrobin results in increased expression of MT3 mRNA CTD PMID:37777166 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO pinostrobin results in increased expression of MUTYH mRNA CTD PMID:37777166 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression ISO pinostrobin results in increased expression of NAIP mRNA CTD PMID:37777166 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO pinostrobin results in increased expression of NINJ1 mRNA CTD PMID:37777166 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nisch nischarin increases expression ISO pinostrobin results in increased expression of NISCH mRNA CTD PMID:37777166 NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A increases expression ISO pinostrobin results in increased expression of NLRP1 mRNA CTD PMID:37777166 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein] CTD PMID:37342552 PMID:37866152 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pinostrobin results in increased expression of NOS3 mRNA CTD PMID:37777166 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO pinostrobin results in increased expression of NR4A1 mRNA CTD PMID:37777166 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO pinostrobin results in increased expression of NTSR1 mRNA CTD PMID:37777166 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression ISO pinostrobin results in increased expression of P2RX1 mRNA CTD PMID:37777166 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO pinostrobin results in increased expression of P2RX7 mRNA CTD PMID:37777166 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO pinostrobin results in increased expression of PDE1B mRNA CTD PMID:37777166 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 increases expression ISO pinostrobin results in increased expression of PELI3 mRNA CTD PMID:37777166 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO pinostrobin results in increased expression of PHLDA3 mRNA CTD PMID:37777166 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase increases expression ISO pinostrobin results in increased expression of PIM2 mRNA CTD PMID:37777166 NCBI chr  X:14,617,582...14,622,851
Ensembl chr  X:14,617,582...14,622,851 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO pinostrobin results in increased expression of PLAUR mRNA CTD PMID:37777166 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO pinostrobin results in increased expression of PLD1 protein CTD PMID:37164308 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Plec plectin decreases expression ISO pinostrobin results in decreased expression of PLEC protein CTD PMID:37164308 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Plxnd1 plexin D1 increases expression ISO pinostrobin results in increased expression of PLXND1 mRNA CTD PMID:37777166 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO pinostrobin results in increased expression of PMP22 mRNA CTD PMID:37777166 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pou3f3 POU class 3 homeobox 3 increases expression ISO pinostrobin results in increased expression of POU3F3 mRNA CTD PMID:37777166 NCBI chr 9:44,945,872...44,948,998
Ensembl chr 9:44,945,872...44,948,992 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO pinostrobin results in increased expression of PPARA mRNA CTD PMID:37777166 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein] CTD PMID:37342552 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression ISO pinostrobin results in increased expression of PTK2B mRNA CTD PMID:37777166 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of QARS1 mRNA CTD PMID:37777166 NCBI chr 8:109,207,705...109,215,738
Ensembl chr 8:109,207,705...109,215,739 		JBrowse link
G Ret ret proto-oncogene increases expression ISO pinostrobin results in increased expression of RET mRNA CTD PMID:37777166 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rnf130 ring finger protein 130 increases expression ISO pinostrobin results in increased expression of RNF130 mRNA CTD PMID:37777166 NCBI chr10:34,342,835...34,456,048
Ensembl chr10:34,342,830...34,456,062 		JBrowse link
G Rnf216 ring finger protein 216 increases expression ISO pinostrobin results in increased expression of RNF216 mRNA CTD PMID:37777166 NCBI chr12:11,454,752...11,576,305
Ensembl chr12:11,454,797...11,576,304 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 increases expression ISO pinostrobin results in increased expression of HLA-F mRNA CTD PMID:37777166 NCBI chr20:3,403,418...3,479,476 JBrowse link
G Rtkn rhotekin increases expression ISO pinostrobin results in increased expression of RTKN mRNA CTD PMID:37777166 NCBI chr 4:115,640,813...115,657,952
Ensembl chr 4:115,640,774...115,657,952 		JBrowse link
G Scfd2 sec1 family domain containing 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCFD2 protein CTD PMID:37164308 NCBI chr14:33,683,348...34,008,232
Ensembl chr14:33,683,273...34,008,213 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCN2A protein CTD PMID:37164308 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scx scleraxis bHLH transcription factor increases expression ISO pinostrobin results in increased expression of SCX mRNA CTD PMID:37777166 NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626 		JBrowse link
G Selenos selenoprotein S increases expression ISO pinostrobin results in increased expression of SELENOS mRNA CTD PMID:37777166 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO pinostrobin results in increased expression of SERPINF1 mRNA CTD PMID:37777166 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 multiple interactions
increases expression
increases phosphorylation		 ISO pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]
pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein
pinostrobin results in increased phosphorylation of SFRP5 protein		 CTD PMID:37164308 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression ISO pinostrobin results in increased expression of SHARPIN mRNA CTD PMID:37777166 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Shisa5 shisa family member 5 increases expression ISO pinostrobin results in increased expression of SHISA5 mRNA CTD PMID:37777166 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Slc10a5 solute carrier family 10, member 5 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SLC10A5 protein CTD PMID:37164308 NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651 		JBrowse link
G Slc25a6 solute carrier family 25 member 6 increases expression ISO pinostrobin results in increased expression of SLC25A6 mRNA CTD PMID:37777166 NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 increases expression ISO pinostrobin results in increased expression of SLC46A2 mRNA CTD PMID:37777166 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO pinostrobin results in increased expression of SLC7A11 mRNA CTD PMID:37777166 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO pinostrobin results in increased expression of SLCO5A1 protein CTD PMID:37164308 NCBI chr 5:6,228,938...6,358,124
Ensembl chr 5:6,228,973...6,352,913 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO pinostrobin results in increased expression of SMAD3 mRNA CTD PMID:37777166 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smim7 small integral membrane protein 7 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SMIM7 protein CTD PMID:37164308 NCBI chr16:17,274,417...17,278,336
Ensembl chr16:17,273,258...17,278,336 		JBrowse link
G Stap2 signal transducing adaptor family member 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of STAP2 protein CTD PMID:37164308 NCBI chr 9:828,369...838,648
Ensembl chr 9:828,372...837,219 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO pinostrobin results in increased expression of STAR mRNA CTD PMID:37777166 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression ISO pinostrobin results in increased expression of STXBP1 mRNA CTD PMID:37777166 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Sycp2l synaptonemal complex protein 2-like increases expression ISO pinostrobin results in increased expression of SYCP2L mRNA CTD PMID:37777166 NCBI chr17:23,589,217...23,645,273
Ensembl chr17:23,592,899...23,648,306 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression ISO pinostrobin results in increased expression of TAF10 mRNA CTD PMID:37777166 NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 increases expression ISO pinostrobin results in increased expression of TCIRG1 mRNA CTD PMID:37777166 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
G Tmem109 transmembrane protein 109 increases expression ISO pinostrobin results in increased expression of TMEM109 mRNA CTD PMID:37777166 NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215 		JBrowse link
G Tmem39a transmembrane protein 39a increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMEM39A protein CTD PMID:37164308 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964 		JBrowse link
G Tmem79 transmembrane protein 79 increases expression ISO pinostrobin results in increased expression of TMEM79 mRNA CTD PMID:37777166 NCBI chr 2:173,798,267...173,803,151
Ensembl chr 2:173,798,267...173,803,046 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMPRSS4 protein CTD PMID:37164308 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein] CTD PMID:37866152 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO pinostrobin results in increased expression of TNFSF14 mRNA CTD PMID:37777166 NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO pinostrobin results in increased expression of TNFSF9 mRNA CTD PMID:37777166 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO pinostrobin results in increased expression of TP53 mRNA CTD PMID:37208425 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO pinostrobin results in increased expression of TRAP1 mRNA CTD PMID:37777166 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO pinostrobin results in increased expression of TRIB3 mRNA CTD PMID:37777166 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 increases expression ISO pinostrobin results in increased expression of TRPM2 mRNA CTD PMID:37777166 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO pinostrobin results in increased expression of TRPV1 mRNA CTD PMID:37777166 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO pinostrobin results in increased expression of VEGFA mRNA CTD PMID:37777166 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO pinostrobin results in increased expression of XBP1 mRNA CTD PMID:37777166 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp746 zinc finger protein 746 increases expression ISO pinostrobin results in increased expression of ZNF746 mRNA CTD PMID:37777166 NCBI chr 4:77,055,008...77,078,968
Ensembl chr 4:77,055,008...77,078,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            protective agent 18187
              antidote 9594
                pinostrobin 158
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  oxacycle 17866
                                    benzopyran 11952
                                      1-benzopyran 11704
                                        flavonoid 7190
                                          flavans 3634
                                            flavanones 555
                                              flavanone 207
                                                (2S)-flavanone 164
                                                  pinostrobin 158
paths to the root