Fer1l4 (fer-1-like family member 4) - Rat Genome Database

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Gene: Fer1l4 (fer-1-like family member 4) Rattus norvegicus
Analyze
Symbol: Fer1l4
Name: fer-1-like family member 4
RGD ID: 1308250
Description: Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to be located in membrane. Orthologous to human FER1L4 (fer-1 like family member 4 (pseudogene)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fer-1-like 4; fer-1-like 4 (C. elegans); fer-1-like protein 4; fer-1-like protein 4-like; LOC100911434; LOC296307
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,996,183 - 165,031,719 (-)NCBIGRCr8
mRatBN7.23144,536,099 - 144,571,634 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,536,099 - 144,571,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,401,697 - 148,437,422 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03157,018,973 - 157,054,698 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,758,499 - 154,794,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,564,604 - 151,600,140 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,564,604 - 151,600,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,929,222 - 157,964,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,427,611 - 146,463,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13146,333,345 - 146,368,742 (-)NCBI
Celera3143,257,857 - 143,293,409 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fer1l4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,996,183 - 165,031,719 (-)NCBIGRCr8
mRatBN7.23144,536,099 - 144,571,634 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,536,099 - 144,571,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,401,697 - 148,437,422 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03157,018,973 - 157,054,698 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,758,499 - 154,794,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,564,604 - 151,600,140 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,564,604 - 151,600,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,929,222 - 157,964,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,427,611 - 146,463,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13146,333,345 - 146,368,742 (-)NCBI
Celera3143,257,857 - 143,293,409 (-)NCBICelera
Cytogenetic Map3q42NCBI
FER1L4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,558,737 - 35,607,562 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,558,866 - 35,607,494 (-)EnsemblGRCh38hg38GRCh38
GRCh372034,146,507 - 34,195,484 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,609,921 - 33,651,008 (-)NCBINCBI36Build 36hg18NCBI36
Celera2030,894,820 - 30,943,779 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,924,013 - 30,973,281 (-)NCBIHuRef
CHM1_12034,047,835 - 34,097,104 (-)NCBICHM1_1
T2T-CHM13v2.02037,279,572 - 37,328,533 (-)NCBIT2T-CHM13v2.0
Fer1l4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,861,059 - 155,894,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,861,059 - 155,894,867 (-)EnsemblGRCm39 Ensembl
GRCm382156,019,139 - 156,053,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2156,019,139 - 156,052,947 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,844,876 - 155,878,683 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,710,581 - 155,744,081 (-)NCBIMGSCv36mm8
Celera2161,953,004 - 161,986,811 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.32NCBI
FER1L4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,509,734 - 24,543,589 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,154,950 - 24,188,711 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,202,278 - 25,236,121 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12424,488,664 - 24,522,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,583,825 - 24,617,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02425,023,084 - 25,056,904 (-)NCBIUU_Cfam_GSD_1.0
FER1L4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11738,900,118 - 38,945,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21744,021,603 - 44,027,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Fer1l4
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000026451
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 1 8
Below cutoff 1 2 7 12 17 25 14 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026451   ⟹   ENSRNOP00000026451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,536,099 - 144,571,634 (-)Ensembl
Rnor_6.0 Ensembl3151,564,604 - 151,600,140 (-)Ensembl
RefSeq Acc Id: NM_001106534   ⟹   NP_001100004
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,996,183 - 165,031,719 (-)NCBI
mRatBN7.23144,536,099 - 144,571,634 (-)NCBI
Rnor_6.03151,564,604 - 151,600,140 (-)NCBI
Rnor_5.03157,929,222 - 157,964,758 (-)NCBI
RGSC_v3.43146,427,611 - 146,463,147 (-)RGD
Celera3143,257,857 - 143,293,409 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100004 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85878 (Get FASTA)   NCBI Sequence Viewer  
  EDL85879 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026451
  ENSRNOP00000026451.5
Reference Protein Sequences
RefSeq Acc Id: NP_001100004   ⟸   NM_001106534
- UniProtKB: D4ABP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026451   ⟸   ENSRNOT00000026451
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABP2-F1-model_v2 AlphaFold D4ABP2 1-1994 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308250 AgrOrtholog
BioCyc Gene G2FUF-47109 BioCyc
Ensembl Genes ENSRNOG00000019467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026451 ENTREZGENE
  ENSRNOT00000026451.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2A_Ferlin UniProtKB/TrEMBL
  C2B_Ferlin UniProtKB/TrEMBL
  C2C_Ferlin UniProtKB/TrEMBL
  C2D_Ferlin UniProtKB/TrEMBL
  C2E_Ferlin UniProtKB/TrEMBL
  C2F_Ferlin UniProtKB/TrEMBL
  FerB UniProtKB/TrEMBL
  FerIin-typ UniProtKB/TrEMBL
  Ferlin UniProtKB/TrEMBL
  Ferlin_C UniProtKB/TrEMBL
KEGG Report rno:296307 UniProtKB/TrEMBL
NCBI Gene 296307 ENTREZGENE
PANTHER PTHR12546 UniProtKB/TrEMBL
  PTHR12546:SF36 UniProtKB/TrEMBL
Pfam FerB UniProtKB/TrEMBL
  FerI UniProtKB/TrEMBL
  Ferlin_C UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PhenoGen Fer1l4 PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019467 RatGTEx
SMART FerB UniProtKB/TrEMBL
  FerI UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
UniProt D4ABP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fer1l4  fer-1-like family member 4  LOC100911434  fer-1-like protein 4-like  Data merged from RGD:6493003 737654 PROVISIONAL
2015-06-23 Fer1l4  fer-1-like family member 4  Fer1l4  fer-1-like 4 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911434  fer-1-like protein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Fer1l4  fer-1-like 4 (C. elegans)   Fer1l4_predicted  fer-1-like 4 (C. elegans) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fer1l4_predicted  fer-1-like 4 (C. elegans) (predicted)      Symbol and Name status set to approved 70820 APPROVED